Báo cáo y học: "Growth factors in lung development and disease: friends or foe?" pptx

... key regulators of alveolar formation, they have also been implicated in abnormal lung remodeling that results in fibrosis and changes in the Commentary Growth factors in lung development and disease: ... Williams ST, Lee H, Malicki DM, Chin EM, Yin S, Tapley J, Ulich TR: Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortali...

Ngày tải lên: 12/08/2014, 18:20

... signalling in inflammatory diseases of the lung. Increased levels of pro-inflammatory and inflammatory cytokines such as IL1, IL6, IL8, and IL15, monocyte chem- otactic protein-1 (MCP-1), TNFα and intercellular ... gene transcription and modulating and cross-regulating signal- ling pathways. Summary The involvement of Wnt signalling in lung development, maintenance, cancer...

Ngày tải lên: 12/08/2014, 16:20

... activates the cyclooxygenase-2 (COX-2) pathway and induces synthesis of prostaglandins including prostaglandin E 2 (PGE 2 ) and 6-keto-prostaglandin F 1α (PGF 1α ). Prostaglandins exert negative feedback ... mitogenesis in vitro, and appears to slow progression of IPF when adminis- tered to patients [15]. Insulin-like growth factor-1 and insulin-like growth factor-binding proteins...

Ngày tải lên: 12/08/2014, 18:20

... [57,58,56]. Tyrosine hydroxylase Tyrosine (tyr) and tetrahydrobiopterin (bh4) are con- verted by tyrosine hydroxylase (TH) into 3,4-dihyroxy- phenylalanine (l-dopa) and dihyrobiopterin (bh2). The velocity ... substrate inhibition of tyrosine hydroxy- lase by tyrosine [23]. Substrate inhibition means that tyro- sine can bind non-enzymatically to TH preventing TH from performing its functio...

Ngày tải lên: 13/08/2014, 16:20

... controls. 105 Nuclear Factor kB NF-kB is a major transcription factor that is induced by a large number of factors, including proinflammatory cytokines and other mediators of stress, and plays a role in the development ... increase in the setting of stress and inflammation. 177 Adenosine has proinflammatory and immunomodulatory effects and may be involved in the pathogenesi...

Ngày tải lên: 08/08/2014, 21:20

... subclassified in sub- sets as defined by LeRoy and colleagues [15,16]. Forty-nine patients were included. Pregnancy was an exclusion criterion. Healthy subjects were included in this study as controls. ... preliminary SSc severity scale (Medsger severity scale), a measure of activity, damage, and severity, was used. This scale is a nine-organ disease severity scale in which for each...

Ngày tải lên: 09/08/2014, 10:23

... L, Maly FE, Zünd G, Turina M: Genetic polymorphisms of apolipoprotein E4 and tumor necrosis factor beta as predisposing factors for increased inflammatory cytokines after cardiopulmonary bypass. ... (LIPC) is a lipolytic enzyme synthesized in hepatocytes playing a major role in HDL metabolism. It takes part in hydrolysis of triacylglycerides and phosphol- ipids of HDL 2 into anti...

Ngày tải lên: 10/08/2014, 10:20

... profiles of key cytokines and CD4+ and CD8+ T lymphocytes, worse lung pathology and more virus-specific, activated CD8+ T lymphocytes in BALF. Mice smoke exposed before influenza infection had ... assayed by zymography, and net gelatinase activity in BALF assayed by digestion of fluorescein cou- pled gelatin, as previously described [12]. Densitometry of zymography gels was done...

Ngày tải lên: 12/08/2014, 15:21

... enzyme–substrate inter- action. For example, in a test tube, matrilysin inactivates α 1 -antiproteinase inhibitor much more efficiently than does gelatinase-B. However, in tissue, at least in inflamed dermis, ... Furthermore, matrilysin may not be the only MMP involved in repair of airway epithelial wounds. Gelatinase- B is also expressed by injured epithelial cells in distal airway...

Ngày tải lên: 12/08/2014, 18:20

... being defined from the morbid anatomy of lung samples resected for cancer. Sakao et al. have argued that tumor necrosis factor (TNF)-α, a potent pro-inflammatory cytokine, may be involved in ... detected in a number of ways including denaturing gradient electrophoresis and denaturing gradient high-performance liquid chromatography. SSCP, single-stranded conformational polymorphism. (c...

Ngày tải lên: 12/08/2014, 18:20