Báo cáo y học: " Oxygen-regulated transcription factors and their role in pulmonary disease" pptx

... muscularization of pulmonary arterioles is significantly impaired, resulting in significantly less medial wall thickening, pulmonary artery hypertension, and right ventricular hypertrophy after 3 weeks ... con- traction and hypertrophy. ET-1 expression is induced within the pulmonary vasculature of hypoxic rats [19], and ET A - receptor antagonists prevent/reverse chronic hypoxi...

Ngày tải lên: 12/08/2014, 18:20

... of this inflammatory process, several MMPs and TIMPs are secreted by activated infiltrating cells and by cells intrinsic to the inflamed site, facilitating penetration into the tissue and structural ... metalloproteinase; PLZF = promyelocytic leukaemia zinc finger protein; SLE = systemic lupus erythematosus; TIMP = tissue inhibitor of metalloproteinase. inflammatory disease. Increased M...

Ngày tải lên: 09/08/2014, 13:22

... Arthritis and Rheumatism 2001, 44:S266. 11. Landgraf RG, Jancar S: Endothelin A receptor antagonist mod- ulates lymphocyte and eosinophil infiltration, hyperreactiv- ity and mucus in murine asthma. Int ... HugoAKatus 1 and F Joachim Meyer* 1 Address: 1 Department of Cardiology, Angiology and Respiratory Medicine, Heidelberg, Germany and 2 Institute for Medical Biometry and...

Ngày tải lên: 12/08/2014, 14:20

... oxidative stress by producing proinflammatory cytokines and chemokines and releasing growth factors. Nevertheless, smoking cannot be the only factor in the development of COPD, since only 15–20% of ... W Ryter 2 and Augustine MK Choi* 2 Address: 1 Department of Pulmonary Diseases, University Hospital Groningen, Groningen, The Netherlands and 2 Pulmonary, Allergy and Critic...

Ngày tải lên: 13/08/2014, 13:20

... contribution of TA to P off→on by competing for the promoter binding sites, or by binding TA to block its DNA-binding or activational domains. Interestingly, in two studies reporting that the same promoters ... ranges in eukaryotic cells [29-32]. Evidently, at the early stage of induction, most of the cells are still in the transcription- ally inactive state and no protein is synth...

Ngày tải lên: 13/08/2014, 23:20

... A binding by ecdysone agonists in the intact Sf-9 cell line. Steroids 65, 537– 542. 245 Minakuchi C, Nakagawa Y & Miyagawa H (2003) Validity analysis of a receptor binding assay for ecdysone ... FEBS and only partially overlapping ligand-binding pockets. The difference of the binding pocket is easy to under- stand by looking at the superimposition between PonA and BYI06830 shown...

Ngày tải lên: 23/03/2014, 04:20

... plays a role in load bearing, and elastin, which conveys elasticity to the aorta. Sex hormones play an impor- tant role in aortic wall compliance by regulating the elastin/col- lagen activity ... [19-27]. Smoking plays important roles in mediating atherosclerosis, elastolytic response, and potentiating inflammation [28-30]. It affects key proteolytic enzymes like MMPs, elastases...

Ngày tải lên: 09/08/2014, 13:22

... copy number [32]. is complexity is likely to be shared by other transcription factors with a direct mitochondrial activity, and it may explain why early work did not detect direct binding ... element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene 2001, 273:1-11. 34. Montminy MR, Bilezikjian LM: Binding of a nuclear pro...

Ngày tải lên: 09/08/2014, 20:22

... mulate, since they are rapidly hydroxylated by oxygen-dependent HIF prolyl-4- hydroxylase domain enzymes (PHD), subsequently captured by the ubiquitin ligase Von-Hippel-Lindau protein (VHL), and ... harvesting for HIF determination, either by immunostaining or by molecular biology techniques may be falsely positive, as hypoxia-induced inhibition of PHD activity is instantaneous, and...

Ngày tải lên: 14/08/2014, 07:21

... SD, Afonin VB and Kakurin VJ. Potassium measurements during hypokinesia and ambulation in establishing potassium changes in trained and untrained subjects. Sports Medicine Training and Rehabilitation, ... electrolyte measurements during and after hypokinesia in determining muscle electrolyte depletion during hypokinesia in rat. Biological Trace Element Research 2002; 90:...

Ngày tải lên: 02/11/2012, 11:12