Báo cáo y học: " The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease" ppt

... develop the disease [13]. commentary review reports primary research Review The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/ skin-derived antileukoprotease) ... antileukoprotease) as alarm antiproteinases in inflammatory lung disease Jean-Michel Sallenave Edinburgh Medical School, Edinburgh, Scotland, UK Abs...

Ngày tải lên: 12/08/2014, 18:20

... only in the case of cathepsin B binding. The contribution of the second binding loop of cystatin A to protease binding varies with the protease, being largest,  45% of the total binding energy, ... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute  45% of the total unita...

Ngày tải lên: 17/03/2014, 10:20

... phenylalanine was therefore mutated to Ala, Leu, Trp or Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme ... property of bF24A is its increased esterase/ amidase ratio. In general the enzyme-catalysed hydrolysis of esters is faster than the hydrolysis of the correspon...

Ngày tải lên: 17/03/2014, 23:20

... spectros- copy [20] and in the case of protein farnesyl transferase by crystal structure analysis [19]. It results in a decrease in the pK value of the thiol group as shown by the release of a proton ... coordinated in the active site of this methyltransferase. Upon binding of coenzyme M to MtaA the number of sulfur ligands to zinc increased by at least one...

Ngày tải lên: 17/03/2014, 23:20

... bridge with the carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results ... these residues in binding the carboxylate linked to the nucleus of penicillin N (Arg160 and Arg162) and the carboxylate of the a-amino- adipoyl side-chain...

Ngày tải lên: 18/03/2014, 01:20

... allergy in a large number of infants[33,34]. There were two major differences between Taylor D s study and the others. The type of probi- otic product was different as well as the timing of the introduction ... strong family history of eczema, allergic rhinitis or asthma, and to their infants for the first six months after delivery. The frequency of developing...

Ngày tải lên: 08/08/2014, 21:20

... activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892. 7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam- matory therapy. ... Moreover, whereas the use of these drugs in the management of acute pain is typically short term (a few days to two weeks), their continuous usage in these experiments was a depa...

Ngày tải lên: 09/08/2014, 01:21

... evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... Gunzler V, Kivirikko KI, Myllyharju J: Cat- alytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its p...

Ngày tải lên: 09/08/2014, 01:22

... Anatomy, Physiology and Clinical Medicine in 1878. (c) Title of the manuscript, meaning The finer changes of joint cartilage in fungous synovitis and caries of the joint-ends”. Fungous synovitis ... [9,10], the increased expression of RANKL and RANK within synovial inflammatory tissue [30–32], and the fact that many proinflammatory mediators present in the s...

Ngày tải lên: 09/08/2014, 01:23

... of the 3- hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reduc- tase enzyme. These include naturally occurring lovastatin, chemically modified simvastatin and pravastatin [1–3] and the synthetically ... structure and organization of bone and other mineralized tissues and the mechanism of calcifi- cation. In: Handbook of physiology, endocrinology, parathyroid gland. Edi...

Ngày tải lên: 09/08/2014, 03:24