Báo cáo y học: " The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease" ppt
Báo cáo y học: " The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease" ppt
... develop the disease [13].
commentary
review
reports primary research
Review
The role of secretory leukocyte proteinase inhibitor and elafin
(elastase-specific inhibitor/ skin-derived antileukoprotease) ... antileukoprotease) as
alarm antiproteinases in inflammatory lung disease
Jean-Michel Sallenave
Edinburgh Medical School, Edinburgh, Scotland, UK
Abs...
Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... only in the case
of cathepsin B binding. The contribution of the second
binding loop of cystatin A to protease binding varies with
the protease, being largest, 45% of the total binding
energy, ... participates in the inhibition of papain
and most likely also of cathepsin L. The side chains of
Leu73 and Pro74 jointly contribute 45% of the total
unita...
Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... phenylalanine was therefore
mutated to Ala, Leu, Trp or Tyr. These mutations may
in uence the shape and volume of the acyl binding pocket
and thereby alter the binding mode and affinity of the
enzyme ... property of bF24A is its increased esterase/
amidase ratio. In general the enzyme-catalysed hydrolysis of
esters is faster than the hydrolysis of the correspon...
Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... spectros-
copy [20] and in the case of protein farnesyl transferase by
crystal structure analysis [19]. It results in a decrease in the
pK value of the thiol group as shown by the release of a
proton ... coordinated in
the active site of this methyltransferase.
Upon binding of coenzyme M to MtaA the number of
sulfur ligands to zinc increased by at least one...
Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... bridge
with the carboxyl group of the a-aminoadipoyl- side-chain
of penicillin N (1), with arginines 74 and 75 apparently
playing a less important role in side-chain binding. Taken
together, the results ... these residues in
binding the carboxylate linked to the nucleus of penicillin N
(Arg160 and Arg162) and the carboxylate of the a-amino-
adipoyl side-chain...
Báo cáo y học: "The role of Probiotics in allergic diseases" pptx
... allergy in a large number
of infants[33,34]. There were two major differences
between Taylor
D
s study and the others. The type of probi-
otic product was different as well as the timing of the
introduction ... strong family history of eczema,
allergic rhinitis or asthma, and to their infants for the first
six months after delivery. The frequency of developing...
Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc
... activity of a glucocorticoid-regulated inflammatory
cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892.
7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam-
matory therapy. ... Moreover, whereas the use of these drugs in
the management of acute pain is typically short term (a
few days to two weeks), their continuous usage in these
experiments was a depa...
Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... evidence for hypoxia in
inflammatory and destructive joint disease, and discusses the
interplay between alterations in oxygen tension, vascularity
and inflammatory signalling pathways. In the present ... Gunzler V, Kivirikko KI, Myllyharju J: Cat-
alytic properties of the asparaginyl hydroxylase (FIH) in the
oxygen sensing pathway are distinct from those of its p...
Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx
... Anatomy, Physiology and Clinical Medicine in 1878. (c)
Title of the manuscript, meaning The finer changes of joint cartilage in
fungous synovitis and caries of the joint-ends”. Fungous synovitis ... [9,10], the increased expression of
RANKL and RANK within synovial inflammatory tissue
[30–32], and the fact that many proinflammatory mediators
present in the s...
Báo cáo y học: "The role of statins as potential targets for bone formation" pptx
... of the 3-
hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reduc-
tase enzyme. These include naturally occurring lovastatin,
chemically modified simvastatin and pravastatin [1–3] and
the synthetically ... structure and organization of bone
and other mineralized tissues and the mechanism of calcifi-
cation. In: Handbook of physiology, endocrinology, parathyroid
gland. Edi...
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