Báo cáo y học: "MicroRNAs in systemic rheumatic diseases" pdf

... DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 2010, 184:6773-6781. 51. Zhao S, Wang Y, Liang Y, Zhao M, Long H, Ding S, Yin ... miR-124a binding in the 3’ UTR of cyclin- dependent kinase 2 (CDK2) and monocyte chemo- attractant protein 1 (MCP-1) mRNA. In fact, induction of miR-124a in RA synoviocytes signifi cantly...

Ngày tải lên: 12/08/2014, 17:21

... important signaling pathways involved in the control of the IL-1/IL-1Ra balance in human monocytes, in so far as inhibition of phosphatidylinositide 3 kinase delta markedly decreases IL-1 while increasing ... the main problem is in fact the inhibition of repair activity. Any type of chronic joint inflammation, whether infectious, inflammatory, or autoimmune, will result in joint des...

Ngày tải lên: 09/08/2014, 14:22

... including severe sepsis, sepsis, systemic in ammatory response syn drome without infection, and verifi ed infection – blood donors, systemic in ammatory res ponse syndrome patients with infections, ... Since its discovery in 1929 as the ‘Koagulations-Vitamin’ by Henrik Dam, the main role assigned to vitamin K has been linked to main taining hemostasis. Vitamin K inhibitors have...

Ngày tải lên: 13/08/2014, 21:21

... Further RCTs on early SSc are needed to assess the real efficacy of CYC in inducing remission and increasing survival. In a previous issue of Arthritis Research & Therapy, Nannini and colleagues ... by a well-conducted meta-analysis and concluded that cyclophosphamide (CYC) treatment does not induce a statistically significant improve- ment in lung function in systemic sclerosis...

Ngày tải lên: 09/08/2014, 01:22

... many different cytokines may be involved. Second, although many cytokines may be involved in the pathogenesis of SLE, research thus far has concentrated on a small group of cytokines, notably tumour ... meeting showed the breadth of interest in the role played by different cytokines in SLE. A large amount of work in mice, and a smaller body of evidence on the effects of anticytokine a...

Ngày tải lên: 09/08/2014, 01:22

... to integrate questions and answers in a systems biology manner. This collective approach could greatly aid in understanding host-virus interactions in an inclusive way. Authors' contributions VJ ... DM: Silencing suppression by geminivirus proteins. Virology 2006, 344:158-168. 25. Chapman EJ, Prokhnevsky AI, Gopinath K, Dolja VV, Carrington JC: Viral RNA silencing suppressors inhib...

Ngày tải lên: 13/08/2014, 05:22

... expansion in lymph nodes and for systemic T cell responses to low antigen concentrations. Int Immunol 2001, 13:1583-1593. 9. Youinou P, Lydyard PM, Mageed RA: B cells underpin lupus immunopathology. ... http://arthritis-research.com/content/5/4/157 157 IL = interleukin; MHC = major histocompatibility complex; SLE = systemic lupus erythematosus. Available online http://arthritis-research...

Ngày tải lên: 09/08/2014, 01:21

... Rolph MS: Over- lapping gene expression profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines inter- leukin-1 beta and tumor necrosis factor. Inflamm Res 2005, 54:10-16. 27. ... these diseases involve the synovial joints, they also have many systemic features. For example, rheumatoid arthritis (RA) is a chronic inflammatory disease that - in additi...

Ngày tải lên: 09/08/2014, 01:22

... chemokine family, characteristically heparin binding proteins which on structural level have four highly conserved cysteine amino acid residues, with the first two cysteines separated by one nonconserved amino ... R, Lutze N, Schymeinsky J, Walzog B: Human neu- trophils promote angiogenesis by a paracrine feedforward mechanism involving endothelial interleukin-8. Am J Physiol Heart Circ Physi...

Ngày tải lên: 12/08/2014, 16:20

... [23]. This link between proinflammatory cytokines and osteoclast formation most likely explains why cytokine-targeted therapy, particularly blockade of TNF, is highly effective in retarding structural damage ... lineage types such as Kupffer cells in the liver or microglia in the brain. It is not fully clear whether some monocytes entering an inflamed joint are already committed to the...

Ngày tải lên: 09/08/2014, 01:22