Báo cáo y học: " Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse" potx

... ACh analysis. The ACh synthesizing enzyme, ChAT, was dem- onstrated in epithelial cells of these bronchi by immuno- histochemistry (Fig. 1). Role of the epithelium and of ACh in 5-HT-induced bronchoconstriction Small ... triggers the release of acetylcholine (ACh) from these cells, which then causes airway constriction [3]. In line with this notion, the presence...

Ngày tải lên: 12/08/2014, 16:20

... cata- lytic domain of the ADAM proteinase [32]. The interac- tion of the catalytic site-bound Zinc atom with a cystein present in the N-terminal extremity of TIMP leads to an inactivation of ADAMs. ... recognized as fertilin-alpha and - beta in 1987 [35] since they could induce the fusion of the sperm with the egg. This process is mediated through the interacti...

Ngày tải lên: 12/08/2014, 14:20

... attractive hypothesis to explain, at least in part, the reduced viral loads observed during peak viremia. A further result of C activation is the induction of the ter- minal C pathway, resulting in the ... prime-boost application of the vaccine iv and intramuscularly, respectively, resulted in detectable nAb-titres in the animals of group 2. Similar to the anim...

Ngày tải lên: 12/08/2014, 23:21

... sensitivity of mannitol and metha- choline to identify EIB of 68.4% and 73.7% and a specif- icity of 44.4% and 55.5% respectively. Sensitivity and specificity for mannitol and methacholine to identify ... replace other challenges for BPT, any of these tests can provide specific information and insight regarding mechanism in a particular patient. Competing interests SDA...

Ngày tải lên: 12/08/2014, 14:20

... burden and morbidity of obesity in the community. Comparison with previous studies examining the preva- lence and associations of chronic cough are difficult due to differences in sampling and other ... can be interpreted as indicating the severity of psychological disturbance on a continuum [35]. In Australian community populations the GHQ-28 has shown sensitivity...

Ngày tải lên: 13/08/2014, 10:20

... [16]. Several lines of evidence point to the involvement of the mito- chondrion and the Bcl-family of proteins in the induction of lymphocyte apoptosis during sepsis. Overexpression of Bcl-2 or ... regions of homol- ogy, the BH1-4 domains; pro-apoptotic Bax-like proteins shar- ing only domains 1–3 [17]; and the group of BH3-only proteins, which contain only dom...

Ngày tải lên: 13/08/2014, 11:23

... at the time of chloroplast origin had poorly defined interactions between Cyt f and plastocyanin and/ or plasto- cyanin and photosystem I, and subsequently the nature of the interactions in the ... knowledge, the work described here and in the related publications [1,7] is the first kinetic analysis of the in vitro interactions Cyt f–plastocyanin and plast...

Ngày tải lên: 21/02/2014, 01:21

... from the hydroxyl side chain of tyrosine 229. This displacement may be facilitated involving by R389 through lowering the pK of the tyrosine hydroxyl group. The proton is delivered to the carboxybiotin ... serine hydroxyl and an aspartic acid, these experiments argue strongly against an acidic function of the serine hydroxyl; (d) upon replacing serine by alanine the enzy...

Ngày tải lên: 08/03/2014, 23:20

... in uen- tial in defining the stability of Compound II. The replacement of the distal histidine residue by alanine or glutamic acid clearly has a profound in uence on the ability of the rAPX enzyme to ... hydrogen-bond- ing structure involving the N e of His42 and the ferryl oxygen. However, although hydrogen-bonding interactions of this kind have been structurally...

Ngày tải lên: 18/03/2014, 01:20

... genotyping. The search led to the pinning down of a single polymorphism disrupting the RUNX1-binding site within the organic cation transporter gene SLC22A4 [5]. Furthermore, and providing a ... previously identified by linkage in sibling pairs, and by thorough haplotype analysis narrowed it down to a single polymorphism (having excluded the remaining nine that showed asso...

Ngày tải lên: 09/08/2014, 01:23