Báo cáo y học: "VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-κB signaling pathway" pot

... elucidate the mechanisms that regulate their expression. Hypoxia-induced mitogenic factor (HIMF) is a protein originally discovered in a mouse model of hypoxia- induced pulmonary hypertension ... purposes) Respiratory Research Open Access Research VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-κB signaling pathway Qiangsong Tong 1 ,...

Ngày tải lên: 12/08/2014, 16:20

... in a synthetic CXCL12α the residues Lys24 and Lys27 by Ser (CXCL12α-K2427S), decreased or abrogated the ability of the chemokine to bind to RA ECs. Ex vivo, synovial ECs from patients with either ... because it is observed in other synovial (OA) and non-synovial (HUVEC) EC types. Interestingly, a higher CXCL12 binding capacity was observed ex vivo in all lines of synovial origin (ei...

Ngày tải lên: 09/08/2014, 07:20

... determine the transfection efficiency. Statistical analysis Results were expressed as the mean ± standard deviation of at least three independent assays. Comparisons were made by analysis of variance, ... of ANK to the production of extracellular inorganic pyrophosphate (ePPi) by chondrocytes and the signaling pathways involved in the regulation of Ank expression by TGF-β1....

Ngày tải lên: 09/08/2014, 10:22

... and Baker’s yeast (Saccharomyces cerevisiae) which is processed by a proprietary technology developed by CK Life Sciences Int’l Inc., Hong Kong, China (CKLS). CKBM had previously been found ... University of Hong Kong in the Department of Biology. His current research is in proteomics. Ying-Jye Wu (Ph.D.) has over 20 years of experience with US biomedical industry and is kn...

Ngày tải lên: 02/11/2012, 11:12

... unremarkable. Family history was significant for lifelong history of polycythemia in her mother, maternal grandmother and her younger sister. Physical examination was unremarkable. Laboratory parameters ... expectancy and do not require phlebotomy. The therapies used for polycythemia vera such as phlebotomy and chemotherapy should not be used in patients who have polycythemia due t...

Ngày tải lên: 08/08/2014, 16:23

... Silman A: Is there an association between anti-TNF monoclonal antibody therapy in rheumatoid arthritis and risk of malignancy and serious infection? Commentary on the meta-analysis by Bongartz ... not only are our findings applicable to clinical practice and biologically plausible, but they also fulfill the dose-effect criterion for causality. The low risk in the comparison group...

Ngày tải lên: 09/08/2014, 08:22

... report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Competing interests The authors declare that they have no competing ... to the buttock intermittently, especially when he adducted and flexed his right hip joint. The pain could be temporarily relieved by either abduction or the use of painkiller...

Ngày tải lên: 11/08/2014, 19:21

... our study even with unstable alveoli because oxygen was exchanged during the portion of the ventilatory cycle in which the unstable alveoli are inflated. This hypothesis was supported by Pfeiffer ... brief overview is as follows. The laboratory of Gil and colleagues produced the first high-quality experiments demonstrating the possibility that there may be many mechanisms by...

Ngày tải lên: 13/08/2014, 08:20

... and inside the thymic pa- renchyma. These data reinforced the hypothesis that adipocytic mesenchymal cells could be possibly im- migrating and/or differentiating in the aging thymus by an active ... aging, adipocytic unilocular cells simply fill a space left by the thymic lymphoid compartment or replace the lymphocytic perivascular space. In the present study, we defined n...

Ngày tải lên: 08/08/2014, 18:20

... 15:69-75. 20. Jin YC, Lee YS, Kim YM, Seo HG, Lee JH, Kim HJ, Yun-Choi HS, Chang KC: (S)-1-(alpha-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) reduces rat myocardial apoptosis against ... may afford a persistent anti- apoptotic effect via a JAK2-STAT3-Bcl-2 pathway. Activation of the PI3K/Akt pathway prevents cardiac myocyte apoptosis and protects the myocardium...

Ngày tải lên: 10/08/2014, 10:20