Báo cáo y học: " Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma" doc

... frequencies, indi- cating that increased arginase activity strongly restricts iNANC nerve-mediated airway smooth muscle relaxation. The increased relaxation after arginase inhibition was completely reversed ... reversed by L-NNA, demonstrating that argin- ase activity attenuates iNANC nerve-mediated airway smooth muscle relaxation by limiting NO production. Since argi...

Ngày tải lên: 12/08/2014, 16:20

... that airway remodeling similar to that of asthma affects CF airways, including changes in airway smooth muscle. In addition, in vivo studies with inhalation of bronchodilators improve the symptoms ... smooth muscle (ASM) contraction. Many inflammatory cytokines are produced in the air- ways in CF patients [13]. Several studies have docu- mented increased levels of interle...

Ngày tải lên: 12/08/2014, 14:20

... A2 by interleulin-1 in human airway smooth muscle. Chest 2003, 123:433S-434S. 14. Lazaar AL, Albelda SM, Pilewski JM, Brennan B, Pure E, Panettieri RA: T lymphocytes adhere to airway smooth muscle ... E, Ingram JM, Hoover GE, Zambrano JC, Hayden FG, Platts-Mills TA, Heymann PW: Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eos...

Ngày tải lên: 12/08/2014, 16:20

... prep- arations, including (1) laminin from EHS tumours that contains laminin type 1 (laminin 111) isoform, (2) affin- ity purified β1 chain-containing laminin from human pla- centa that includes laminin-1 ... (laminin 111), 2 (laminin 211), 6 (laminin 311), 8 (laminin 411), 10 (laminin 511) isoforms, and (3) affinity purified α2 chain-containing laminin from human placenta that consists of la...

Ngày tải lên: 12/08/2014, 16:20

... Given that endoG is normally regulated to exist in nuclei at a very low level, it may have a role in survival in normal states by eliminating kinked DNA formed in guanine-rich regions. EndoG has ... sequence specificity, endoG may recognize a three-stranded junction structure formed at the starting point of the RNAÆDNA hybrid. Alternatively, it may recognize the looping-out single-stra...

Ngày tải lên: 23/03/2014, 21:20

... with an increased risk of SLE include history of hypertension, drug allergy, type I/II sun- reactive skin type, and blood transfusions (all moderately increasing the risk) and family history substantially ... smoking habits (>20 years) and was evident even if daily smoking intensity was only moderate. Duration of smoking rather than intensity has also been found to be a risk factor in a...

Ngày tải lên: 09/08/2014, 01:22

... population Sheng-Yu Jin *1 , Seung-Jae Hong *2 , Hyung In Yang 3 , Sang-do Park 3 , Myung-Chul Yoo 4 , Hee Jae Lee 1 , Mee-Suk Hong 1 , Hae-Jeong Park 1 , Seo Hyun Yoon 1 , Bum-Shik Kim 1 , Sung- Vin Yim 1 , ... of exon 8 G/A BtgI polymorphism (codon 594) in the ER-α gene and ER-α haplotypes of three polymorphisms (PvuII in intron 1, XbaI in intron 1, and BtgI in exon 8) with prima...

Ngày tải lên: 09/08/2014, 01:23

... pro- duction of cysteinyl-leukotrienes and LTB 4 were increased[9]. In addition, similar findings have been reported in airway fluids for the levels of these lipid medi- ators; thus, an increase in LTB 4 ... stores is low, but LX biosynthesis can be amplified by select TH2 cytokines, namely interleukin-4 and interleukin-13 [14,15]. In addi- tion, exogenous LTA 4 can be converted b...

Ngày tải lên: 12/08/2014, 11:22

... post-injury at the time of interview. While all patients shared the same disability weight of zero pre-injury, the disparity post injury reflected the level of severity (Figure 2). In term of intangible ... households were strategic in mini- mizing the loss of household income by selecting Table 1: One-year costs associated with treatment by level of traumatic brain injury (Unit: USD, 1US...

Ngày tải lên: 13/08/2014, 11:22

... characterize ovine endotoxin-induced lung injury, a frequently used model of acute lung injury. Recombinant human activated protein C (rhAPC), with its anticoagulant, anti-inflammatory, fibrinolytic and antiapoptotic ... using Student's t test, or using the Mann–Whitney U test when appropriate. Results Infusion of endotoxin caused lung injury, manifested by increments in pulmonary arte...

Ngày tải lên: 13/08/2014, 11:22