CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes ppt
CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes ppt
... RESEARC H ARTIC L E Open Access
CP690,550 inhibits oncostatin M-induced
JAK/STAT signaling pathway in rheumatoid
synoviocytes
Kiyoshi Migita
*
, Atsumasa Komori, Takafumi ... activation
of the JAK/STAT pathway in rheumatoid synoviocytes. Inhibition of these pro-inflammatory signaling pathways by
CP690,550 could be important in the treatment of RA.
Introducti...
Báo cáo y học: "κ The TRAF6-NFκB signaling pathway in autoimmunity: not just inflammation" ppsx
... which
immunocytes interact (Fig. 1). Because the same cell signaling
pathways regulate survival and activation in the periphery and
in the thymus, however, mutations or polymorphisms in the
pathway can ... events leading to NFκB
activation after stimulation of APCs are shown in Fig. 1. In
resting APCs, NFκB dimers are sequestered in cytoplasm in
complex with the inhibitory (...
Báo cáo y học: "α α Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis" pps
... protein-1
complex-dependent and hypoxia-inducible factor 1-indepen-
dent signaling pathway. J Biol Chem 2000, 275:27874-2782.
43. Matsumoto K, Kanmatsuse K: Interleukin-18 and interleukin-12
synergize ... a consequence, an increased
APAAP = alkaline phosphatase/antialkaline phosphatase; CI = confidence interval; HIF = hypoxia inducible factor; KDR = kinase insert domain
protein receptor; m...
Báo cáo y học: "Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts" doc
... protease inhibitors, resulting in enhanced
proteolytic activity [41] and controls cell proliferation by
processing the insulin-like growth factor-binding protein-1
[42]. MMP-11 is, therefore, involved ... latent TGF-β1 in RA (see above), resulting in more TGF-β1
activity in the arthritic joint. Indeed, increased levels of active
TGF-β1 have recently been reported in RA synovial flui...
Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... be
involved in the control of HIF-α, in particular phosphatidyl-
inositol 3-kinase [47-52], p42/p44 mitogen-activated protein
kinase [53], p38 mitogen-activated protein kinase and protein
kinase ... of
α-subunits, and two transactivating domains, namely the
amino-terminal transactivating domain and the carboxyl-
terminal transactivating domain (C-TAD). The C-TAD has
been shown to interact...
Báo cáo y học: "κ Increased AP-1 and NF-κB activation and recruitment with the β combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocyte" ppt
... enhances tumor necro-
sis factor alpha-induced synthesis of interleukins 1, 6, and 8
in skin and synovial fibroblasts: a possible role as a ‘fine-
tuning cytokine’ in inflammation processes. Arthritis ... combinations of these cytokines.
Immunofluorescence staining
Immunofluorescence staining was performed on control
and stimulated rheumatoid synoviocytes (i.e. before and
30 min after...
Báo cáo y học: "Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis" ppt
... of the inflammatory
cascade. MMP1 and MMP3 are involved in processes of
tissue remodelling, including wound healing and angio-
genesis, but also in cancer invasion and inflammatory joint
destruction ... as interleukin-1 [37], whereas plasmin and trypsin
activate the precursors of both proteins [38]. In addition,
MMP1 and MMP3 interact at the protein level. MMP3
activates latent MMP1, en...
Báo cáo y học: " Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis" ppt
... citrullinated proteins
may be present in the RA synovium, thus far three proteins
can be considered as candidate autoantigens in RA:
citrullinated fibrin, citrullinated vimentin and citrullinated
histones.
Is ... of
peptidylarginine deiminase V and histone deimination in gran-
ulocytes. J Biol Chem 2002, 277:49562-49568.
19. Tak PP, Firestein GS: Apoptosis in rheumatoid arthritis....
Báo cáo y học: "The molecular mechanism of osteoclastogenesis in rheumatoid arthritis" pptx
... examined whether
sIL-6R and IL-6 are involved in joint destruction in RA
patients [13]. The number of osteoclast-like multinucleated
cells found in the synovial tissues derived from the knee
joint ... [28,29] examined the contribu-
tion of soluble factors in the interaction between T cells
and synoviocytes in RA patients. IL-17 induced production
of IL-6 and leukemia inhibitory fa...
Báo cáo y học: "Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis" ppt
... azathi-
oprine. The inhibitors of TNF-α were used in 47 patients
(42 patients in combination with MTX, three patients in
combination with azathioprine, one patient in combination
with cyklosporine, ... of
survivin in the pathogenesis of arthritis.
Studying the variability of survivin levels in patients with RA,
we observed that in most cases survivin levels were
inclined to decr...
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