CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes ppt

... RESEARC H ARTIC L E Open Access CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes Kiyoshi Migita * , Atsumasa Komori, Takafumi ... activation of the JAK/STAT pathway in rheumatoid synoviocytes. Inhibition of these pro-inflammatory signaling pathways by CP690,550 could be important in the treatment of RA. Introducti...

Ngày tải lên: 12/08/2014, 15:23

... which immunocytes interact (Fig. 1). Because the same cell signaling pathways regulate survival and activation in the periphery and in the thymus, however, mutations or polymorphisms in the pathway can ... events leading to NFκB activation after stimulation of APCs are shown in Fig. 1. In resting APCs, NFκB dimers are sequestered in cytoplasm in complex with the inhibitory (...

Ngày tải lên: 09/08/2014, 06:23

... protein-1 complex-dependent and hypoxia-inducible factor 1-indepen- dent signaling pathway. J Biol Chem 2000, 275:27874-2782. 43. Matsumoto K, Kanmatsuse K: Interleukin-18 and interleukin-12 synergize ... a consequence, an increased APAAP = alkaline phosphatase/antialkaline phosphatase; CI = confidence interval; HIF = hypoxia inducible factor; KDR = kinase insert domain protein receptor; m...

Ngày tải lên: 09/08/2014, 01:21

... protease inhibitors, resulting in enhanced proteolytic activity [41] and controls cell proliferation by processing the insulin-like growth factor-binding protein-1 [42]. MMP-11 is, therefore, involved ... latent TGF-β1 in RA (see above), resulting in more TGF-β1 activity in the arthritic joint. Indeed, increased levels of active TGF-β1 have recently been reported in RA synovial flui...

Ngày tải lên: 09/08/2014, 10:20

... be involved in the control of HIF-α, in particular phosphatidyl- inositol 3-kinase [47-52], p42/p44 mitogen-activated protein kinase [53], p38 mitogen-activated protein kinase and protein kinase ... of α-subunits, and two transactivating domains, namely the amino-terminal transactivating domain and the carboxyl- terminal transactivating domain (C-TAD). The C-TAD has been shown to interact...

Ngày tải lên: 09/08/2014, 01:22

... enhances tumor necro- sis factor alpha-induced synthesis of interleukins 1, 6, and 8 in skin and synovial fibroblasts: a possible role as a ‘fine- tuning cytokine’ in inflammation processes. Arthritis ... combinations of these cytokines. Immunofluorescence staining Immunofluorescence staining was performed on control and stimulated rheumatoid synoviocytes (i.e. before and 30 min after...

Ngày tải lên: 09/08/2014, 01:23

... of the inflammatory cascade. MMP1 and MMP3 are involved in processes of tissue remodelling, including wound healing and angio- genesis, but also in cancer invasion and inflammatory joint destruction ... as interleukin-1 [37], whereas plasmin and trypsin activate the precursors of both proteins [38]. In addition, MMP1 and MMP3 interact at the protein level. MMP3 activates latent MMP1, en...

Ngày tải lên: 09/08/2014, 01:23

... citrullinated proteins may be present in the RA synovium, thus far three proteins can be considered as candidate autoantigens in RA: citrullinated fibrin, citrullinated vimentin and citrullinated histones. Is ... of peptidylarginine deiminase V and histone deimination in gran- ulocytes. J Biol Chem 2002, 277:49562-49568. 19. Tak PP, Firestein GS: Apoptosis in rheumatoid arthritis....

Ngày tải lên: 09/08/2014, 01:23

... examined whether sIL-6R and IL-6 are involved in joint destruction in RA patients [13]. The number of osteoclast-like multinucleated cells found in the synovial tissues derived from the knee joint ... [28,29] examined the contribu- tion of soluble factors in the interaction between T cells and synoviocytes in RA patients. IL-17 induced production of IL-6 and leukemia inhibitory fa...

Ngày tải lên: 09/08/2014, 06:22

... azathi- oprine. The inhibitors of TNF-α were used in 47 patients (42 patients in combination with MTX, three patients in combination with azathioprine, one patient in combination with cyklosporine, ... of survivin in the pathogenesis of arthritis. Studying the variability of survivin levels in patients with RA, we observed that in most cases survivin levels were inclined to decr...

Ngày tải lên: 09/08/2014, 06:22