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Báo cáo y học: "Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study" ppt

Báo cáo y học:

Báo cáo y học: "Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study" ppt

... article as: Schlesinger et al.: Canakinumab relieves symp toms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results ... anti-inflammatorytherapy on quality of life in patients with acute Gouty Arthritis and demo nstrates the significant value of potent anti-inflammatory therapy.We also report that canakinumab achieved ... health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging studyNaomi Schlesinger1*, Marc De Meulemeester2, Andrey...
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Báo cáo y học: " High Human T Cell Leukemia Virus Type-1(HTLV-1) Provirus Load in Patients with HTLV-1 Carriers Complicated with HTLV-1-unrelated disorders" docx

... Uemura A, Sugahara K, Nagai H, Murata K, Hasegawa H, Hirakata Y, Tsukasaki K, Yamada Y, Kamihira S: An ATL cell line with an IgH pseudo-rearranged band pattern by southern blotting: a pitfall of ... 19:4954-60.12. Satoh M, Toma H, Sugahara K, Etoh K, Shiroma Y, Kiyuna S, Takara M, Matsuoka M, Yamaguchi K, Nakada K, Fujita K, Kojima S, Hori E, Tanaka Y, Kamihira S, Sato Y, Watanabe T: Involvement of ... expansion. Cases 3-14; aberrant bands mainly with faint multiple clonal bands, Final diagnosis was based on the integrated findings of an LN SBH test and clinico-pathological examinations. ALCL;...
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Báo cáo Y học: High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences doc

Báo cáo Y học: High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences doc

... protein of Leishmaniais stimulated by zinc and may involve lamininzinc-finger like sequencesKeya Bandyopadhyay, Sudipan Karmakar, Abhijit Ghosh and Pijush K. DasMolecular Cell Biology Laboratory, ... i n enhancing laminin–enactin and laminin–collagen type I V binding. Previously,the enactin binding site was mapped to one of the zinc-fingercontaining repeats on t he laminin A chain [9]. ... 1).Indirect immunoblotting revealed a 67-kDa protein bandusing laminin as the primary probe followed b y treatment with anti-laminin Ig and alkaline phosphatase-conjugatedsecondary Ig (lane...
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Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx

Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx

... control of mRNA translation in mammalian cellsinvolves the regulation of a range of components of thetranslational machinery, principally by changes in theirphosphorylation, leading to modulation ... 4E-BP1 and p70 S6k appear to lie onseparate branches of this pathway [19]. p70 S6k is activated by insulin and growth factors (reviewed in [20]) and appearsto play a role in up-regulating the translation ... Gingras, A C.,Sonenberg, N. & Thomas, G. (1997) The insulin-induced signal-ling pathway leading to S6 and initiation factor 4E binding protein1 phosphorylation bifurcates at a rapamycin-sensitive...
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Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf

Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf

... all-trans-retinoic acid (ATRA). Manser et al.[7]have isolated a brain protein kinase, PAK68, by purifying a protein with Rac1/Cdc42-GTP binding ability. Becausethe kinase binds tightly to an affinity column ... differenti-ation of HL-60 cells induced with ATRA.Induction of Rac and PAKHL-60 cells were treated with 1 lMATRA for a week,andRacandPAKwereassayedinbothcytosolandmembrane fractions. Rac occurs as ... immunoblot analysis of gp91phox in the plasmamembrane fraction. A major band corresponding to an apparentmolecular mass of 91 kDa was indicated by an arrow. Induced dif-ferentiation times (days) are...
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Báo cáo y học: "Innovative combination strategy to enhance effect and diminish adverse effects of glucocorticoids: another promise" pot

... fully synonymous with inflammatory and immunosuppressive activity and with adverse effects, respectively. For instance, hypopituitary-pituitary-adrenal axis suppression and increased risk of infection ... effects and adverse effects are manifold.Ultimately, the proof of the pudding is in the eating. Com-parative clinical trials of long duration with adequate numbers of patients and regular assessments ... important, and the results reported by Zimmermann and colleagues [2]are promising indeed. However, laboratory models, rats, and mice are not patients and the glucocorticoid mechanismsleading...
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Báo cáo y học: "Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium" docx

... (BPD) is a widespread condition characterized by recurringstates of mania and depression. Lithium, a direct inhibitor of glycogen synthase kinase 3(GSK3) activity, and a mainstay in BPD therapeutics, ... forward 5'-CAGCTTCCAGTCCCTGACTCAAG-GTTGTCCCACATAC-3', RevErbα reverse 5'-GGCGTA-GACCATTCAGCGCTTCATTATGACGCTGAG-3'; Bmal1forward 5'-CCGTGCTAAGGATGGCTGTTCAGCACATG-3', ... RJ, Ishikawa T, Miyazaki J, Takahashi JS, Sancar A: Differential regulation of mammalian period genes and cir-cadian rhythmicity by cryptochromes 1 and 2. Proc Natl AcadSci USA 1999, 96(21):12114-12119.52....
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Báo cáo y học: "Objective Structured Clinical Examinations (OSCEs), psychiatry and the Clinical assessment of Skills and Competencies (CASC)Same Evidence, Different Judgement" ppsx

... longcases with each long case involving a partly observedinterview of a real patient. Part II also involved an oralexamination involving some standardized patient man-agement problems.Authors ... with standardized patients: state of the art. Teaching and Learning in Medicine1990, 2:58-76.16. Swanson DB, Norcini JJ: Factors influencing reliability of tests usingstandardized patients. Teach ... in Psychiatry: Associations with the Clinical Skillls examination and otherindicators. Academic Psychiatry 2004, 28:122-128.26. Hodges B, Lofchy J: Evaluating psychiatry clinical clerks with a mini-objective...
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Báo cáo y học: " The interaction between the PARP10 protein and the NS1 protein of H5N1 AIV and its effect on virus replication" pot

... members of PARP family have PARP activity and can modify part of protein in nuclei [9]. Studies also found that the protein family plays certain regulating role in DNA replication and repair [10,11], ... glutamate rich region and PARP domain (aa610-1025), and PARP domain (aa 691–1025). Nuclear export signal and two ubiquitin-binding motifs are located at the overlapping area of glutamate rich ... that PARP10 is a widely expressed protein [16], indicating that PARP10 has wide and fundamental biological functions, and may play certain role in some basic pathways. Therefore, the interaction...
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