prevention of infection in patients with cancer

... definitive conclusion Clinicians should remain vigilant for infection in patients with RA treated with GC therapy Introduction Infection is a major cause of morbidity and mortality in patients with ... reported on infections treated with antibiotics All adverse events collected, reported only if occurred in or more patients 17 infections in 40 patients in GC arm, 22 infections in 41 patients in placebo ... of all existing studies Inconsistent capture or reporting of infections has an impact on the weighting of studies within a meta-analysis Fewer events within a study result in an increased variance

Ngày tải lên: 12/08/2014, 17:22

... benefit of a CSF for established infections is unproven, it may be considered in the setting of profound neutropenia (ANC < 100/mcL) and in serious infections, including invasive fungal infection ... receiving colony growth factor support and in patients receiving mucotoxic regimens consisting of cytarabine plus anthracyclines This finding is consistent with the bowel being a principal portal of ... study compared the echinocandin caspofungin with conventional amphotericin B in adults with invasive candidiasis.18 A total of 239 patients were enrolled In the modified intent-to-treat analysis,

Ngày tải lên: 10/03/2017, 19:28

... and 57 days, in two patients the treatment was interrupted because of oesophagitis, in three patients due to infection. Two patients of group II showed progressive disease dur- ing induction chemotherapy. ... Inter- fraction interval in patients with stage III non-small-cell lung cancer treated with hyperfractionated radiation therapy with or without concurrent chemotherapy: final results in 536 patients. ... in elderly patients. In the group of patients treated with concurrent chemo-radiation 9 out of 40 patients < 70 years presented severe late toxicity (23%); 5 of the 16 eld- erly patients in

Ngày tải lên: 09/08/2014, 10:21

... associated with clinical markers of cachexia and with presence of cachexia in our cohort While TIMP-1 was counterindicated as a marker in combination with jaundice, combining TIMP-1 with cachexia ... al Clinical significance of the measurements of serum matrix metalloproteinase-9 and its inhibitor (tissue inhibitor of metalloproteinase-1) in patients with pancreatic cancer: metalloproteinase-9 ... patients with (n = 6) and without cachexia (n = 18), and in PDAC patients with (n = 8) and without cachexia (n = 18) (patients with jaundice were excluded) Shapiro-Wilks testing in combination with

Ngày tải lên: 24/07/2020, 00:43

... efficacy of a combination of oxaliplatin, leucovorin, irinotecan, and 5-FU (FOLFIRINOX) to monotherapy with gemcitabine, FOLFIRINOX has been established as the firstline therapy in patients with inoperable ... after intravenous infusions and intrametastatic injection (detection of anti-drug-antibodies (ADA)),  Investigation of the kinetics of H-1PV genomes in blood following intravenous and intrametastatic ... Mechanistically, preclinical data suggest that nab-paclitaxel increases gemcitabine levels by decreasing intratumoral cytidine deaminase activity [17] In absence of preclinical data of combining ParvOryx,

Ngày tải lên: 06/08/2020, 03:51

... Breast Cancer Liver cancer Gastrointestinal, Breast, Lung, and other Cancer Lung cancer Gastrointestinal cancer Lung cancer Gastrointestinal cancer Gastrointestinal, Urogenital, Lung and other cancer ... Unknown Gastrointestinal cancer Lung cancer Unknown Gastrointestinal cancer Unknown Liver cancer Gastrointestinal, Breast, Lung, and other Cancer Liver cancer Unknown Gastrointestinal, Breast, ... totally informed of diagnosis and totally uninformed of diagnosis in cancer patients Risk of bias in included studies Physical function Included studies were assessed for risk of bias using the ROBINS-I

Ngày tải lên: 06/08/2020, 05:23

... indicating improved tolerability of the nintedanibcontaining regimen [21] Reassuringly, the safety profile of nintedanib observed in the present study was entirely consistent with that seen in other ... therapy (excluding nintedanib) during the previous weeks; active ulcers or infectious disease; injuries with incomplete wound healing; pregnancy or breastfeeding; brain metastases requiring therapy; ... objective of this preplanned subanalysis was to assess the effect of continuous daily dosing with nintedanib on the tumour vasculature in patients with CRC using DCE-MRI Additional objectives included

Ngày tải lên: 14/10/2020, 13:28

... effects [4, 5] Optimizing the quality of life of patients with cancer, during and after treatment, is an evolving field Helping cancer patients strengthen their ability to cope with their diagnosis ... familiar with in clinical practice Herein, we examine the ability of art therapy to improve the quality of life of cancer patients Our pilot study seeks to demonstrate the clinical effectiveness of ... research These findings are consistent with other studies reporting the benefit of art therapy in cancer, [32] on emotions in women with breast cancer [33], and as a form of mindfulness that

Ngày tải lên: 05/11/2020, 01:39

... (participants, interventions, comparators, outcomes and study design) [18] Inclusion criteria included: (1) patients with COPD; (2) The interventions included any type of inhaled corticosteroids, including ... risk of blinding of participants and personnel bias, study had high risk of blinding of outcome assessment bias, and study had high risk of incomplete outcome data One study had unclear risk of ... Page of 13 Fig Risk of bias of the included studies Discussion This meta-analysis of 17 multicenter RCTs (including 20,478 patients) suggested that short-term use of ICSs increased the risk of

Ngày tải lên: 05/05/2021, 03:28

... incomplete absorption of a single dose of varenicline, leading to insufficient levels of the drug in the brain [46]. Furthermore, Freedman [47] reported the case of a patient with schizophrenia ... C]CHIBA-1001 [52,53] in the intact brains of patients with schizophrenia is currently underway. Finally, several limitations of this study should be men- tioned. One of the main limitations of this trial ... gat- ing P50 deficits in patients with schizophrenia, and that tropisetron had a significant impact on the sustained visual attention measured with the RVP subtest of CAN- TAB in non-smoking patients.

Ngày tải lên: 08/08/2014, 23:21

... in clinical practice Finally, these finding represent an urging need for developing effective physical training interventions for patients with schizophrenia 16 Competing interests The authors ... of large doses of chlorpromazine Acta Med Scand 1968, 184:499-509 14 Heggelund J, Nilsberg GE, Hoff J, Morken G, Helgerud J: Effects of high aerobic intensity training in patients with schizophrenia-A ... years old and >7.8 mmol—L-1 in patients ≥50 years old; elevated LDL-cholesterol, 4.3> mmol—L-1 in patients mmol—L-1 in patients 30-49 years old and >5.3 mmol—L-1 in patients ≥50 years old; reduced

Ngày tải lên: 11/08/2014, 16:21

... Changing and maintaining body position d410 Changing basic body position x d415 Maintaining a body position x x x Carrying moving and handling objects d430 Lifting and carrying objects x d440 Fine ... did. In addition, only the patients in stage 2 experienced improvements in eating and drinking due to HPN. Eating and drinking can still be heavily limited in patients shortly after the start of ... vulnerable population with cancer. Background Weight loss is a common and serious problem in patients with cancer [1-3]. In patients with cancer in the abdomi- nal cavity weight loss is often caused by

Ngày tải lên: 12/08/2014, 01:21

... previous work obtained in infants [13] and children [1,2] with CF Schaedel et al used FEV1 in terms of % predicted of normal, to demonstrate a slower rate of decline in patients with missense mutations ... FEV1 declines in children and young adults with CF, there is an increase in the elastic load and work of breathing, resulting in a rapid shallow breathing pattern, that is associated with further ... Vasodilatation of the earlobe was achieved by rubbing the lobe with a nicotinate paste (Finalgon) [26,27,32,33] for at least 10 minutes and heating with an infrared lamp During quiet breathing, the

Ngày tải lên: 12/08/2014, 14:20

... of response for 64 patients with AS and 14 patients with PsA, loss of response for 115 patients with AS and 29 patients with PsA, and intoler- ance for 56 patients with AS and nine patients with ... 97% of 1,250 patients with AS completed the 12- week treatment with adalimumab. During the complete study, 1% of patients with AS (10 of 924) without prior anti-TNF therapy and 3% of patients with ... 78.8% of 376 patients with no history of anti-TNF therapy. The percentages of patients with PsA attaining a Physician's Global Assessment of psoriasis of "Clear/Almost clear" increased

Ngày tải lên: 12/08/2014, 14:22

... cough, with infusion reactions (IRs) reported in 5% to 20% of patients [9,12]. Although the clinical trials did not show a significant increase in the risk of infections with the use of infliximab, ... half year of infliximab treatment in refractory RA patients. The main reasons for discontinuing treatment are infections and infusion reactions. Tuberculosis and other infections remain an important ... occurring during this study are provided in the Supporting information in Additional file 1. Treatment discontinuations The number of patients remaining in the study at each visit is shown in Figure

Ngày tải lên: 12/08/2014, 14:22

... baseline, 98% of patients were suffering from moderate-to-extreme pain. The percentage of patients with no or mild pain was numerically greater in most canakinumab groups compared with triamcinolone ... assessment of joint swelling in patients receiving canakinumab 150 mg (c) or triamcinolone acetonide 40 mg (d). Physicians assessed inflammation in the target joint using the following tenderness ... of the AEs were mild or moderate in severity. The inci- dence of infections was low; 7% of all canakinumab-trea- ted patients and 7% of those in the triamcinolone acetonide group. Anti-canakinumab

Ngày tải lên: 12/08/2014, 15:22

... choosing approaches to therapy, including factors influencing health-related quality of life. Presently, little is known about the determinants of health-related quality of life (HRQOL) in patients ... population of PAH patients are as severe (and in many respects more so) than those reported in studies of patients with other severely debilitating and life-threatening conditions such as spinal cord injury, ... hemodynamic values in determining HRQOL. Such findings, if confirmed, emphasize the importance of such functional endpoints in clinical trials, and may help direct choices of therapy so as to bring about

Ngày tải lên: 12/08/2014, 18:22

... analysis of five clinical trials in which ato- moxetine was generally shown to be e ffective in impro v- ing certain aspects of HRQoL in 794 children and adolescents with ADHD [31]. In addition, in ... quality of patients in the last week?’ ) and appetite (’How would you rate the appetite of patients in the last week?) were also assessed at each of the study visits, using a 5-point rating scale with ... improved in 23.7% and 25.9% of patients, respecti vely, and worsened in 32.5% and 32.4% of patients, respectively. ContinueduseofOROSMPHatstudyendbythe treating physician was planned in 76.9%,

Ngày tải lên: 13/08/2014, 18:22

... occurring in in individuals guidelines remain the primary mechanism for offering over their lifetime (3) This risk begins at age 40 years evidence-based recommendations, such guidelines may and increases ... 2017:871–98 of patient-related factor(s) that increase the risk of procedure The INR should be rechecked within 24 bleeding hours of the procedure, particularly if a normal INR Interrupt therapy with ... undergoing procedures with uncertain achieved bleed risk and the presence of patient-related factor(s) that increase the risk of bleeding Consider interrupting a VKA on the basis of both clinical

Ngày tải lên: 01/05/2017, 20:27

... establishing themselves in developing countries also1 Infection of gall-bladder and its complications is an important cause of morbidity and mortality in these patients2 The pathogenesis of bile infection ... Institute, over a period of two months in 2017 Total of 50 patients diagnosed with cholecystitis and undergoing cholecystectomy were included in this study which comprised of 25 patients having ... was seen in 8.1% of the cases This in contrast with very high polymicrobial infection rate of 69.5% in study of Sahu et al.,9and31.5% in study of Shenoy et al.,7(2014) Overall, Amikacin (81%),

Ngày tải lên: 16/01/2020, 00:16