Báo cáo y học: "The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors" doc
Báo cáo y học: "The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors" doc
... conflicting findings in the litera-
ture that indicate both procatabolic [19,20] and antica ta-
bolic effects of IL-6 in chondrocytes and synoviocytes
[21-23]. In contrast, the role of IL-6 in inflammatory ... development
of OA [7]. LIF is a glycoprotein that was originally
defined by its ability to induce the terminal differentia-
tion of murine M1 myeloid leukemia cell...
Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps
... the inflamed synovium may play a role in the pathophysi-
ology of OA. The low-grade OA synovitis is itself cytokine-
driven, although the levels of proinflammatory cytokines are
lower than in rheumatoid ... synovium can
influence the production of degradative enzymes and the
destruction of cartilage. In this study, we investigate the role of
synovial macrophages and...
Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... second binding loops of cystatin B and
family 2 cystatins and also what residues of this loop in
cystatin A may participate in the interaction.
To elucidate the role of the second binding loop of ... participates in the inhibition of papain
and most likely also of cathepsin L. The side chains of
Leu73 and Pro74 jointly contribute 45% of the total
unitary free...
Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... and volume of the acyl binding pocket
and thereby alter the binding mode and affinity of the
enzyme for PAA and derivatives thereof, while maintaining
the hydrophobicity of the binding site.
To ... (k
cat
/K
m
)forp-hydroxyphenylgly-
cine methyl ester and phenylglycine methyl ester that were
similar to the wild-type values, whereas the specificity con-
stants for p-hydroxyphenyl...
Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... indicating
that, in the absence of coenzyme M, zinc is probably
coordinated by a single sulfur ligand and three oxygen or
nitrogen ligands. In the presence of coenzyme M, one
(N/O)-ligand was replaced by sulfur, ... distinct changes in the zinc ligands. In the
His237 fi Ala and Cys239 fi Ala mutants, coenzyme M
also seemed to bind efficiently by ligation to zinc indicating
that so...
Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... carboxyl group of the a-aminoadipoyl- side-chain
of penicillin N (1), with arginines 74 and 75 apparently
playing a less important role in side-chain binding. Taken
together, the results of this and ... residues in
binding the carboxylate linked to the nucleus of penicillin N
(Arg160 and Arg162) and the carboxylate of the a-amino-
adipoyl side-chain (Arg266). The resul...
Báo cáo y học: "The role of Probiotics in allergic diseases" pptx
... delivery. The frequency of developing
atopic dermatitis in the offspring was significantly
reduced by 2, 4, and 7 years [26-28], by 50%, 44%, and
36% respectively.
Similar studies have yielded ... in
Estonian and Swedish infants. Clin Exp Allergy 2005, 35(2):153-9.
12. Bjorksten B, et al.: Allergy development and the intestinal
microflora during the first year of life. J Aller...
Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc
... critical role of COX-2 in
mesenchymal cell differentiation during skeletal repair.
Using COX-1-null and COX-2-null mice, they demon-
strated the essential role of COX-2 in both endochondral
and intramembranous ... their role in bone metabolism and repair
remains unclear.
Review of the evidence
To determine the role of COX-2 in bone repair, investiga-
tors have st...
Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... evidence for hypoxia in
inflammatory and destructive joint disease, and discusses the
interplay between alterations in oxygen tension, vascularity
and inflammatory signalling pathways. In the present ... signalling systems, namely NF-κB and HIF.
Mimicking hypoxia by treatment of cells with small interfering
RNA against PHD-1 or PHD-2 or the pan-hydroxylase
inhibitor dimethylox...
Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx
... consequently lead to increasing inter-
est in the role of osteoclasts in local bone erosion that is
driven by the hypothesis that synovial pannus makes use
Review
The role of osteoprotegerin in arthritis
Georg ... Collagen-induced arthritis
Species Rat Mouse Rat
Dose 1 mg/kg/day 6.4 mg/kg/day 3 mg/kg/day
Start Onset of symptoms Onset of symptoms Onset of symptoms
Dur...
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