Báo cáo y học: "The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies" pdf

... that investigated the expression pattern of the Notch family members in articular cartilage and the eventual involvement of this pathway in the modulation of the physiology and pathology of ... degradation of the articular cartilage is a complex process involving several actors, including signaling pathways like the Notch pathway. Further work is re...

Ngày tải lên: 12/08/2014, 15:22

... reported on the role of cytokines in RP, either in patients or in the corresponding animal models. In the CIA model, several cytokines have been shown to play major roles in the inflammatory process, ... anti-inflammatory mediators as well as proinflammatory ones. The cytokine interleukin-10 (IL-10) has been in focus for many years in autoimmune arthritis and...

Ngày tải lên: 09/08/2014, 01:24

... in the November issue 2009 of the Journal of Brachial Plexus and Peripheral Nerve Injury [1]. We congratulate the Jour nal for the interest in this topic. This innovative study demonstrated the ... by sub-acu te and chronic low back pain and/ or sciatica: this exerts an important impact on the quali ty of life, causing interfer- ence of sleep and enjoyment of...

Ngày tải lên: 10/08/2014, 10:20

... complex interventions like CQI experimental designs that focus on measuring out- comes but are blind to the study of the innovation itself, the contexts into which they are introduced, and the ... related to articulating the linkages between CQI and other aspects of the regulatory, financing, and performance frameworks within the health system would help define...

Ngày tải lên: 11/08/2014, 05:21

... lymphocytes are required for their recruitment into the airways following airway allergen exposure. Thus, CD8 + T lymphocytes are involved in some of the systemic proc- esses in allergic eosinophilia, ... washed in 2% penicillin/streptomycin in PBS (Gibco BRL, Paisley, Scotland) and homogenized in 1% penicillin/streptomycin in PBS by homogenizer (POLY- TRON R PT 1200, Ki...

Ngày tải lên: 12/08/2014, 16:20

... and tracheal expression. We went on to examine the effect of potential modulators of TLR4 expression in respiratory epithelium pertinent to airways disease. Using an airway epithelial cell line, ... modulate TLR4 expression and function in human intestinal epithe- lium [24,25]. The inflammatory milieu in the airways in Salmeterol upregulates TLR4 membrane protein exp...

Ngày tải lên: 12/08/2014, 15:21

... acceptor site and subsequently the sjTREC was cloned in to the EcoRV restriction site of the TOPO TA Vector (Invitrogen, Groning, The Nether- lands). Based on the DNA concentration, measured by spectrophotometry ... occurs in both alleles and if the cell did not divide upon the rearrangement. sjTRECs are exported from thymus to the periphery within recent thymi...

Ngày tải lên: 18/06/2014, 16:20

... the cytoplasm. The shuttling protein 4E-T [5] is thought to transfer eIF4E to the nucleus, where it appears to be important in transporting the cyclin D1 mRNA to the cytoplasm [13]. The increase in ... scaffold protein eIF4G to the dorsal site of eIF4E allows recruitment of several other factors to the mRNA, e.g. eIF4A, the poly(A)-binding protein (PABP),...

Ngày tải lên: 23/03/2014, 21:20

... possibility of involvement of the MAPK pathway in regulation of c-Myc sta- bility, we devised serial experiments using the pathway spe- cific inhibitors 10058-F4, an inhibitor of c-Myc transcriptional activity, ... known to prevent cell cycle progression under the growth inhibitory effect of TGF1 [29-32]. The aim of the present study was therefore to reveal t...

Ngày tải lên: 09/08/2014, 01:22