the role of pi3 kinase pathway in androgen action
Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... Protein targeting to the microsomes requires the cotranslational insertion of the newly synthesized protein into the microsomal membrane, where the N-terminal hydrophobic signal sequence of the ... 9A), confirming the role of endogenous FDX + FDXR in supporting the activity To further confirm the role of endogenous FDX + FDXR in supporting the catalytic activity, we transformed the FDX (Yah1)- ... was preincubated for The reaction was initiated by the addition of mm NADPH, and continued for 30 at 37 °C in a shaking water bath The reaction was terminated by the addition of 250 lL of ice-cold...
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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... $28,000 in average annual salary) Preserving Value Continuing education is important to preserving the market value of specialized education – particularly in professional fields Continuing education ... Shippensburg University Small Business Initiative in the Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Best Practice Highlights...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... induce apoptosis in various cell lines [8–15,29], the inhibitory effect of TS on the cell growth at higher concentrations might prevent the increase in the enhancing effect of TS on LPS/IFN-induced ... for 5min The amount of protein of the solubilized cells was determined with a bicinchoninic acid protein assay kit (PIERCE, Rockford, IL, USA) using bovine serum albumin as a standard The solubilized ... study, to obtain information about the mode of actions of TS, we examined the effect of TS on LPS/IFNinduced NO production in VSMC We found that TS activated LPS/IFN-induced NO production in VSMC through...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... Ala219 of the catalytic site and His135 of the Mg2+ binding site The most striking result was the loss of the psychrophilic character of mutant W260K/A219N (as reflected by a threefold increase of the ... value in this temperature range is considerably lowered On the basis of the model, the behavior of the G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The ... with the aim of reducing the spatial constraints originating from the side-chain interactions between Tyr269 and Ala261 (Fig 2C) The main difference between the G261A and G261A/Y269A enzymes is the...
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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx
... evaluate the OS-fitness of the clone, the ratio of the specific absorbance in the presence of 10 lgÆmL)1 HEL to that in the absence of HEL was taken as an index To analyze the effect of the type of each ... antigen binding, this ‘increasing the affinity by increasing the VH ⁄ VL interaction’ might represent a mechanism of increasing Fv affinity This is also supported by the kinetic study of purified ... clarify the effect of the interface mutations on the antigenbinding affinity To investigate systematically this unsought relationship between the antigen-binding affinity of Fv and the VH ⁄ VL interaction...
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Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt
... Cardie, Vincent Ng, David Pierce, Chris Buckley Examining the role of statistical and linguistic knowledge sources in a general-knowledge que stion answering system In Proceedings of the 6th Applied ... hypernyms in the answer semantic form Step 3: The assessment of the similarities of dependencies In the third step, two classes of similar dependencies are considered, generating unications of the ... example, in the case of question Q209: Who invented the paper clip ?, the expected answer type is P ERSON and so is the subject of the verb invented , lexicalized as the nominalization inventor...
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Báo cáo " THE ROLE OF GIFT RECIPIENT PERCEPTION IN CHANGING BRAND ATTITUDES AND GIVER - RECIPIENT RELATIONSHIP " potx
... change their brand attitude, may suggest an interesting implication for the new brand advertising strategy Instead of focusing on the content of the message which only emphasizes the benefits of the ... birthday This finding is just reverse of the finding of Belk (1973) Ruth, Brunel, Otnes (1999) classified categories of gift-giving into public occasion (i.e., Christmas, Chinese New Year), individual ... situational conditions of gift-giving may differ according to characteristics of the gift-giving occasion, whether the presentation of the gift is public, private, or anonymous, and whether the gift is...
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The Role of Savings and Wealth in Reducing ―Wilt‖ between Expectations and College Attendance pdf
... important for explaining wilt In the case of income, youth living in low-income households experience higher levels of wilt (45%) than youth living in either modest-income (35%) or high-income (23%) ... financing school Conley (2001) finds that a doubling of net worth results in an 8.3% increase in the probability of attending college Further, when net worth is included in the model, Black youth are ... youth Youth savings Youth were asked in 2002 whether they had a savings or bank account in their name If they had an account, they were also asked whether they were saving some of this money for...
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Báo cáo khoa học: The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism pdf
... Harndahl et al ¨ levels through the interaction of glucokinase with binding proteins [5,6] The glucokinase regulatory protein (GKRP) is a specific inhibitor of glucokinase [5] and also a nuclear ... that the increase of Glc6P in the presence of S4048 was caused by the inhibition of Glc6P hydrolysis in the absence of detectable changes in glucose phosphorylation S4048 causes inactivation of ... significant role for glucokinase protein through macromolecular interactions in accounting for the greater glycogenic potency of glucokinase compared with hexokinase I overexpression Thus, other explanations...
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Báo cáo khoa học: "Examining the Role of Linguistic Knowledge Sources in the Automatic Identification and Classification of Reviews" doc
... the short ones) have all zeroes in them In other words, none of the bigrams from the training set appears in these reviews This suggests that the main problem with the bigram model is likely to ... Following Pang et al (2002), we use frequency as presence In other words, the ith element of the document vector is if the corresponding unigram is present in the document and otherwise The resulting ... relation is capturing two different situations, one in which the author himself likes the movie, and in the other, the author’s cousin likes the movie The overgeneralization resulting from these “stemmed”...
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Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf
... strong indications for the involvement of a bacterial P450 in the hydroxylation of octane in Rhodococcus rhodochrous, the role of bacterial P450s in alkane degradation in addition to the well-established ... biological functions The proteins displaying the lowest similarity to the other P450s are those involved in oxylipin biosynthesis (2–6% amino acid identity) This can be explained in part by their bifunctional ... enzymes The FUM6 protein (CYP505B1) intervenes in one of the first steps in fumonisin synthesis by hydroxylation of the polyketide-amino acid at C-14 and C-15 (Fig 3) Fum6 deletion mutants of F verticilloides...
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The Role of Interest Rate Swaps in Corporate Finance doc
... the transaction from the vantage point of firm A, the floatingrate payer The cost of synthetic floating-rate financing is determined by the cost of servicing fixed-rate debt plus the net cost of the ... to the desire on the part of firms to hedge cash flows against the effects of interest rate volatility The timing of the appearance of interest rate swaps, coming as it did during a period of volatile ... account of the value of a prepayment option, they add the premium on a callable swap into the total cost of synthetic fixed-rate financing Finally, they also take account of transactions and administrative...
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A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx
... unfolding of one of the I27 modules in the chain Unfolding then extends the overall length of the protein, relaxing the pulling force to a low value As the slack in the length is removed by further ... bridging the A’ and G b-strands of the I27 protein during the main unfolding barrier.[39] To further validate this view and gain insight into the role of solvent hydrogen bonds in protein unfolding, ... variability of protein collapse 2.6 Identifying the Nature of the Underlying Interactions in Protein Folding Figure To compare all recordings from the force-ramp experiments, the protein length during the...
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The Role of Digital Identity Management in the Internet Economy doc
... explains some of the key concepts and outlines some of the basic IdM processes The range of conceptions of identity is very broad The examination of the following concepts is for the purposes of ... on the impact of identity theft on individuals.7 1.1 The importance and benefits of IdM Online transactions – and many other types of online interactions – have become mainstream activities in ... to take into account in the assessment of the security risks to − and privacy impact on − the delivery of online services, and in determining appropriate levels of security In the case of sensitive...
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Báo cáo khoa học: Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling pot
... than those in the lipids of the surrounding membrane In fact, this fatty acid composition favors a tighter packing of phospholipids and cholesterol, increasing the rigidity of these domains [32–35] ... extraction during lipid raft isolation Moreover, these studies have provided some insights into the significance of the localization of the P2X7 receptors in lipid rafts regarding the regulation of ... formulation of the ‘lipid raft’ hypothesis in the context of membrane transport in polarized epithelial cells [27] It was postulated that domains rich in cholesterol and sphingolipids are preformed in the...
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Báo cáo khoa học: Tertiary structure in 7.9 M guanidinium chloride ) the role of Glu53 and Asp287 in Pyrococcus furiosus endo-b-1,3-glucanase pot
... contribute to the optimization of electrostatic charges balance of pfLamA in the native state, independently of their interaction with calcium The role of electrostatic interactions in protein stability ... kinetics of non-native interactions in protein folding: a single point mutant signicantly stabilizes the N-terminal domain of L9 by modulating non-native interactions in the denatured state J ... however, the integrity of the calcium binding site formed by Asp287 and Glu53 is essential for interaction with the cation in 7.9 m GdmCl An interesting nding of the present study is the signicant...
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Báo cáo khóa học: The role of N-linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis pdf
... Properties of the iron-binding site of the N-terminal lobe of human and bovine lactotransferrins Importance of the glycan moiety and of the non–covalent interactions between the N- and C-terminal lobes ... lactoferrin where the protein has to survive the harsh environment of the gastrointestinal tract Thus, on the basis of this study, rhLF may be preferred over bLF in oral applications of lactoferrins in ... trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrum Unusual resistance of human apolactoferrin to proteolytic digestion...
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Báo cáo khoa học: The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein ppt
... both ADAM10 and TACE are involved in the shedding of APP, neither ADAM is involved in the shedding of ACE Furthermore we show that APMA can distinguish between the shedding of ACE and APP Materials ... dose-dependent increase in the shedding of ACE (Fig 3B,C), with a 12-fold increase in the amount of soluble ACE in the CHO cell medium observed with 500 lM APMA The effect of APMA on the shedding of ACE ... cells in the absence or presence of APMA Following this second incubation, the level of sAPPa in the medium was examined (Fig 4A,B) There was no significant difference in the level of sAPPa in the...
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Beautiful Places: The Role of Perceived Aesthetic Beauty in Community Satisfaction docx
... containing the same information, we conduct collinearity tests (VIF) when the regressions are run FINDINGS We now report the findings of a multivariate regression analysis to determine the community ... they not appear to contain the same information, since the clustering is generally made within a similar distance the main exception is the close connection between beauty of physical setting ... to the findings for individual characteristics Generally speaking, these individual characteristics explain far less variation in the satisfaction levels than the community-related factors in...
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