... they may not favorably affect capillary perfusionand, thereby, mitigate the failure of oxygen and other sub-strate delivery and exchange. In the present issue of CriticalCare, Dubin and colleagues ... are reminded of yesteryear, when purgatives and bloodletting were the established therapies. In the 18th and even the 19th centuries, these were intended to rid the patient’sbody of the injurious ... purged andCommentaryChallenging the rationale of routine vasopressor therapy for management of hypotensionMax Harry Weil and Wanchun TangWeil Institute of Critical Care Medicine, Rancho Mirage,...