... requirement of IκB kinase for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy Arthritis Rheum 2003, 48:1901-1912 Wrighton CJ, Hofer-Warbinek ... responses in rheumatoidarthritis Clin Exp Immunol 1984, 57:123-129 Matthews N, Emery P, Pilling D, Akbar A, Salmon M: Subpopulations of primed T helper cells in rheumatoidarthritisArthritis Rheum ... cytokine for macrophages in rheumatoidarthritis J Clin Invest 1994, 93:921-928 Robinson E, Keystone EC, Schall TJ, Gillett N, Fish EN: Chemokine expression in rheumatoidarthritis (RA): evidence of...
... criteria commonly used in rheumatoidarthritis by reason of discontinuation of the initial TNF-a inhibitor ACR, American College of Rheumatology (see Figure legend for description of ACR20, ACR50 and ... American College of Rheumatology: American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic diseasemodifying antirheumatic drugs in rheumatoidarthritisArthritis ... reported outcomes of multiple switches for the same group of patients, so the same group of patients might have contributed to more than one combination of outcome measures and number of biologics...
... diagnosis of SLE were measured (Figure 1A) At the manufacturer’s threshold of 100 U/ ml, a sensitivity of 60.4% and a specificity of 98.9% were calculated for the diagnosis of SLE The results for eight ... individuals were tested A sensitivity of 60.4% and a specificity of 98.9% were calculated for the diagnosis of SLE at the manufacturer’s threshold of 100 IU/ml Only (2.2%) of 357 disease controls with ... criteria for the classification of systemic lupus erythematosus Arthritis Rheum 1982, 25:1271-1277 Hochberg MC: Updating the American College of Rheumatology revised criteria for the classification of...
... Accuracy of Veterans Administration databases for a diagnosis ofrheumatoidarthritisArthritis Rheum 2004, 51:952-957 Losina E, Barrett J, Baron JA, Katz JN: Accuracy of Medicare claims data for ... activity indices forrheumatoid arthritis: validation of a clinical activity score Arthritis Res Ther 2005, 7:R796-806 van Gestel AM, Haagsma CJ, van Riel PL: Validation ofrheumatoidarthritis improvement ... effectiveness of medications forrheumatoidarthritis (RA) due to the lack of a validated algorithm for this outcome We created and tested a claims-based algorithm to serve as a proxy for the clinical...
... proliferation ofrheumatoid synovial cells and the development ofarthritis in the experimental model of collagen type II-induced arthritis (CIA) Results Effect of MK-4 on the viability of fibroblast-like ... & Gay S (2000) Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction Arthritis Res 2, 59–64 21 ... mixing mL of 0.9% saline, mL of incomplete Freund’s adjuvant and mL of 0.3% CII solution CIA was induced by an intradermal injection of 200 lL of CII emulsion (collagen II mgÆmL)1) at the base of the...
... ratio of IFN-γ/IL-5, from Th1 in favour of a Th2 profile [6,7] We wished to investigate this modulation of a Th1-driven response (IFN-γ production) in the context of stimulated human R325 Arthritis ... inhibitor of LPSinduced TNF-α, whereas IL-10 is relatively unaffected The slight inhibition of IL-10 by elevation of cAMP is thought to be a consequence of the potent inhibition of TNF-α The failure of ... Institute of Rheumatology is supported by a core grant from the Arthritis and Rheumatism Council of Great Britain References Feldmann M, Brennan FM, Maini RN: Role of cytokines in rheumatoid arthritis...
... early rheumatoidarthritis Rheumatology (Oxford) 2004, 43:906-914 Ward MM, Lubeck D, Leigh JP: Longterm health outcomes of patients with rheumatoidarthritis treated in managed care and fee -for- service ... with rheumatoid arthritis: a longitudinal analysis Arthritis Rheum 2004:2082-2093 Fuchs HA, Kaye JJ, Callahan LF, Nance EP, Pincus T: Evidence of significant radiographic damage in rheumatoidarthritis ... indicative of high clinical conformity of classifications by different scores All of these findings indicate that content validity of the CDAI is well maintained despite the absence of CRP as...
... presence of TNF-α (10 ng/ml) for 24 hours, after which the expression of mRNA for various components of NFκB was examined As shown in Fig- Page of 10 (page number not for citation purposes) Arthritis ... the presence of SCF (10 ng/ml) and GM-CSF (1 ng/ml) After 24 hours of incubation, chemical transfection of siRNAs was performed, and incubated for hours Cell cultures and measurement of MMP-1 and ... Page of 10 (page number not for citation purposes) generation of fibroblast-like cells was analyzed using a Spearman's rank correlation test Results Expression of mRNAs for various components of...
... Impairment of quality of life: rheumatoidarthritis versus sarcoidosis Neth J Med 1999, 54:86-95 Borchers AT, Keen CL, Cheema GS, Gershwin ME: The use of methotrexate in rheumatoidarthritis Semin Arthritis ... perceptions of treatment with anti-TNF therapy forrheumatoid arthritis: a qualitative study Rheumatology 2004, 43:1034-1038 Westhoff G, Listing J, Zink A: Loss of physical independence in rheumatoid arthritis: ... of areas of skin Yes Yes s830 Structure of nails Yes Yes Yes Yes International Classification of Functioning, Disability and Health (ICF) categories of the ICF Core Set forrheumatoid arthritis...
... weeks of age) that suffered from severe arthritis (score 3) (KS) were used; WT littermates were used as controls The severity ofarthritis was graded for each paw on a scale of to for the degree of ... three isoforms of IL-1Ra protein, which possess inhibitory activity against IL-1, are synthesized by alternative splicing of a single gene, we produced mice deficient in all three isoforms of IL1Ra ... Firestein GS, Zvaifler NJ: Rheumatoid Arthritis: A Disease of Disordered Immunity New York: Raven Press; 1992 Iwakura Y: Roles of IL-1 in the development ofrheumatoid arthritis: consideration...
... at a concentration of µM each The temperature profile consisted of an initial 95°C step for 10 minutes (for Taq activation), followed by 40 cycles of 95°C for 15 seconds, 60°C for minute, and then ... were rinsed for minutes in distilled water, immersed for minute in 95% ethanol, and dried with a stream of nitrogen gas Page of 14 (page number not for citation purposes) Forty-two of the most ... analysis of microarray data in juvenile rheumatoidarthritis (JRA) neutrophils Data show clustering of control subjects to the left neutrophils of the grid based on patterns of gene expression Data of...
... with one degree of freedom NHS, Nurses' Health Study; RA, rheumatoid arthritis; RF, rheumatoid factor Page of 12 (page number not for citation purposes) Available online http:/ /arthritis- research.com/content/10/3/R52 ... Alfredsson L: Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a populaPage 11 of 12 (page number not for citation purposes) Arthritis Research & Therapy ... Nurses' Health Study; RA, rheumatoidarthritis OK Page of 12 (page number not for citation purposes) Available online http:/ /arthritis- research.com/content/10/3/R52 Table Effect of PTPN22, CTLA-4, and...
... plot illustrates the ofrheumatoidarthritis severity (CIRAS) Thisclaims-based index median and interquartile range for the tertiles of the claims-based index ofrheumatoidarthritis severity (CIRAS) ... (pvalue)) Page of (page number not for citation purposes) Available online http:/ /arthritis- research.com/content/10/4/R95 Table Suggested scoring method for claims-based index ofrheumatoidarthritis ... ACR, American College of Rheumatology; RARBIS, rheumatoidarthritis records-based index of severity Page of (page number not for citation purposes) Available online http:/ /arthritis- research.com/content/10/4/R95...
... treating rheumatoidarthritisof the knee Special thanks to Bonnie Hami, MA (USA) for editing this manuscript References 10 11 American College of Rheumatology Subcommittee on RheumatoidArthritis ... arthroplasty is the standard treatment for severe arthritis and deformity of the knee [5], but there is currently no successful treatment before the severe stage of RA Many doctors simply prescribe ... Arthritis Guidelines: Guidelines for the management ofrheumatoidarthritisArthritis Rheum 2002, 46:328-346 Martin SD, Scott RD, Thornhill TS: Current concepts of total knee arthroplasty J Orthop...
... Tao X, Cai JJ, Lipsky PE: The identity of immunosuppressive components of the ethyl acetate extracts and chloroform methanol extract (T2) ofTripterygiumwilfordii Hook F J Pharmacol Exp Ther 1995, ... Semin Arthritis Rheum 1997, 26:713-723 Tao X, Cush JJ, Garret M, Lipsky PE: A phase I study of ethyl acetate extract of the Chinese antirheumatic herb Tripterygiumwilfordii hook F in rheumatoidarthritis ... Fan FZ, Wang B, Lipsky PE: Benefit of an extract ofTripterygiumWilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study Arthritis Rheum 2002, 46:1735-1743...
... producing a deformity This choice of technique for tendon grafting features the advantage of the source of donor tendon being readily accessible in the same forearm The presence of this tendon ... the rheumatoid- arthritis patient [3-8] Primary repair involves the end-to-end suture of the two ends of the damaged tendon, and, as best we are aware, is generally not feasible forrheumatoid patients, ... surgical repair by any of these techniques are often unsatisfactory The diffuse nature of the tendon damage, combined with fibrosis, atrophy, and retraction of the muscle, Figure of the wrist made...
... relevance of the curriculum content and didactic quality of information delivered to journalists (process evaluation) and, b) explore the effects of such programs on reporting of HIV/AIDS related information ... sample of 46% of the total of reports available in English Each report was reviewed by at least two members of our team In cases of non-agreement, which were very rare, the senior author of this ... a session on issues of people living with HIV (PLWHIVs) adequately allocated time for journalists to become informed of the diverse needs of PLWHIVs, including the issue of HIV-related stigma...
... study of cigarette smoking and risk ofrheumatoidarthritis in female health professionals Arthritis Rheum 1999, 42:910-917 Khaw KT, Tazuke S, Barrett-Connor E: Cigarette smoking and levels of adrenal ... smoking, and rheumatoid factor production in rheumatoidarthritisArthritis Rheum 2002, 47:403-407 Silman AJ, Newman J, MacGregor AJ: Cigarette smoking increases the risk ofrheumatoidarthritis ... factors, smoking, and the risk forrheumatoidarthritis Epidemiology 1990, 1:285-291 Houssien DA, Scott DL, Jonsson T: Smoking, rheumatoid factors, and rheumatoidarthritis Ann Rheum Dis 1998,...
... Role of synovial fibroblasts in the pathogenesis ofrheumatoidarthritisArthritis Res 2000, 2:361-367 Fassbender HG: Histomorphological basis of articular cartilage destruction in rheumatoidarthritis ... Gay RE, Gay S: Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction Arthritis Res 2000, 2:59-65 ... attachment of fibroblasts-like cells to ECM In rheumatoidarthritis (RA), attachment of synovial fibroblast to the ECM is an important initiating step in the progressive destruction of articular...
... TP, Gohlke F: Correlation of power Doppler sonography with vascularity of the synovial tissue of the knee joint in patients with osteoarthritis and rheumatoidarthritisArthritis Rheum 2001, 44:331-338 ... Doppler ultrasonography for assessment of synovitis in the metacarpophalangeal joints of patients with rheumatoid arthritis: a comparison with dynamic magnetic resonance imaging Arthritis Rheum 2001, ... between joint damage and disability in rheumatoidarthritis Rheumatology (Oxford) 2000, 39:122-132 van der Heijde DM: Plain X-rays in rheumatoid arthritis: overview of scoring methods, their reliability...