Báo cáo y học: "Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-a inhibitor" ppsx

... TA, Uffmann M, Smolen JS: Benefit of very early referral and very early therapy with disease-modifying anti- rheumatic drugs in patients with early rheumatoid arthritis. Rheumatology (Oxford) 2004, ... consis- tently recommended for patients with active RA and a history of inadequate response to synthetic DMARDs [5], the management of patients who stopped an...

Ngày tải lên: 12/08/2014, 15:22

... 964 individuals at the manufacturer’s cutoff of 100 U/ml. At a comparable specificity of 99%, the sensitivity amounted to 59.9% for the Anti-dsDNA -NcX ELISA, 54.1% for the Farr assay, 53.6% for the antinucleosome ... (Lübeck, Germany). Receiver operating characteristic curve analyses were performed to compare the sensitivity and specificity of each assay. The te...

Ngày tải lên: 12/08/2014, 15:22

... one in the service of another. Autonomy The principle of autonomy is reflected in the recent trend toward healthcare planning in concert with patients values and preferences. The advance directives ... Patient autonomy can thus be at odds with physicians’ imperative to benefit the patient, as in the case of requests for unproven or useless treatments. Autonomy can...

Ngày tải lên: 12/08/2014, 18:20

... important for the clinician to be comfortable with the side-effect profile and be able to discuss potential safety concerns regarding these therapies. Among the safety concerns with the use of INCs ... safety standards set by the currently available therapies for AR. Understanding the potential concerns and the data behind these concerns should give clinicians...

Ngày tải lên: 08/08/2014, 21:20

... conceived of and designed the study. UB acquired the data. PO performed the statistical analysis. UB prepared the first draft of the manuscript and PO and LK made significant contributions to the final ... more on the level of standard care in South Africa rather than theefficacyoftheinterventionoffered.Also,somemay question whether such a comparatively expensive inter-...

Ngày tải lên: 11/08/2014, 16:22

... microfluidic devices for analysis of clinically relevant analytes present in urine and saliva. Analytical and Bioanalytical Chemistry 2010, 397(5):1821-1829. 21. Menon R, Zhang Q, Zhang Y, Fermin ... due to the pain and discomfort of the procedure; the following his- tology requires expert analysis and is therefore expensive; and issues such as under- sampling can lead to mis...

Ngày tải lên: 13/08/2014, 13:20

... they may not favorably affect capillary perfusion and, thereby, mitigate the failure of oxygen and other sub- strate delivery and exchange. In the present issue of Critical Care, Dubin and colleagues ... are reminded of yesteryear, when purgatives and blood letting were the established therapies. In the 18th and even the 19th centuries, these were intended to rid the pati...

Ngày tải lên: 13/08/2014, 18:22

... (EDA) of fibronectin, with the anti-inflammatory cytokine IL-10. They showed the accumulation of this fusion protein at the site of inflammation, good therapeutic efficacy and a safety profile that ... antibody directed against a specific target fused to a cytokine, thus retaining the functions of both the antibody and the cytokine. In cancer, the use of single-c...

Ngày tải lên: 09/08/2014, 14:22

... out the study and drafted the manuscript. MZ, CG, and BB participated in the study and study analysis. JK participated in the interpretation of the results and gave the advices for improving the manuscript. ... surfactant is recognized as the standard therapy for premature neo- nates and children with acute respiratory failure [4,5]. In patients with ARDS/ALI, desp...

Ngày tải lên: 13/08/2014, 21:21

... Introduction Rheumatoid arthritis (RA) is a chronic condition, which leads to varying degrees of functional impairment and disability. In early stages, symptoms reflecting the inflammatory process often ... report the use of a novel sand- wich ELISA using a combination of two monoclonal anti- bodies for the detection of COMP in serum. The purpose of the study was...

Ngày tải lên: 09/08/2014, 01:21