Báo cáo y học: " RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1" pdf

... RFX1 recruits SUV39H1 to the promoter regions of the CD11a and CD70 genes in CD4 + T cells, thereby regulating local H3K9 tri-methylation levels. These findings shed further light on the central ... [21]. To investigate the effect of aberrant histone methylat ion on the expression of the auto- immune related genes CD11a and CD70, we analyzed H3K9 tri-methyla...

Ngày tải lên: 12/08/2014, 15:22

... chemokine receptors expression in memory Th cells and thus the migratory potentials of the memory Th cells seem to be the same between the three groups. Abbreviations Ag: antigen AS: asymptomatically ... competing inter- ests. Authors' contributions All authors participated in the design of the study. KA con- ducted the patient contact and characterization, ce...

Ngày tải lên: 13/08/2014, 13:22

... induces its auto-phosphorylation and subsequently the activation of both phospholipase PLCγ and protein kinase C, which in turn activates the mitogen-acti- vated protein kinase pathway involving the ... interests The authors declare that they have no competing interests. Authors' contributions CB performed the RT-PCR experiments, the analysis of the data, and drafte...

Ngày tải lên: 09/08/2014, 14:21

... suggesting that the mechanisms of resist- ance in these subjects do not depend on exposure to the virus but rather might be linked to constitutive factors. It is noteworthy in this respect that heterozygous ... and found that both entry and post-entry steps of HIV-1 replication could be affected. Interestingly, the restriction in one of these subjects also affected other lenti...

Ngày tải lên: 13/08/2014, 09:20

... of the pro- moter switching from the inactive to the active state. Maintenance of the active state, however, does not require continued occupancy of the promoter by the TA. In the absence of the ... that the cells turned gene templates into the active state at different times through the induction period, owing to the stochastic nature of binary switching. Since...

Ngày tải lên: 13/08/2014, 23:20

... condition that is affecting motor activity, would inevitably contribute to redistribution of electrolytes in the body resulting to changes in tissue electrolyte content [1-3] and plasma electrolyte ... depletion is inversely related to K + intake, that is, the higher K + intake, the greater the risk for the decreased K + deposition, the higher K + losses and the...

Ngày tải lên: 02/11/2012, 11:12

... immediately before treatment and at 10 days, and 6, 9, and 24 months after treatment . Clinical Measurements To assess the treatment results, the following pre-operative and intra-operative clinical ... characteristic is largely responsible for the consistency of the active component that can act as a barrier to the spread of any bacteria penetrating the tissues incl...

Ngày tải lên: 03/11/2012, 11:35

... Py/Zn treatment. After 6 h of treatment of Zn at the indicated concentration with or without Py, the number of necrotic and apoptotic cells were determined by trypan blue staining and TUNEL assay, ... presence of Py (Fig. 1A). To determine the characteristics of cell death induced by Py/Zn treatment, we counted the number of necrotic and apoptotic cells by trypan blue...

Ngày tải lên: 23/03/2014, 21:20

... services and the families in directly addressing the problem; and (b) the indirect costs, i.e. mainly the losses in productivity caused by the disease, borne by the individual, the family or the employer. Methods Study ... costs consist of opportunity cost of time lost due to morbidity and premature mortality. The morbid- ity-related component includes the pr...

Ngày tải lên: 08/08/2014, 20:23

... of autoreactive cells can ‘slip through the net’ of central toler- ance into the periphery and thereby potentially mediate autoimmunity. This phenomenon can be readily demon- strated by the experimental ... phenom- ena by the patterns of regulatory cytokines that these cells could secrete, and the parsimony thus offered seemed much more attractive as a theory. In contr...

Ngày tải lên: 09/08/2014, 01:23