Báo cáo y học: "A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis" potx

... 176:1983-1998. doi:10.1186/ar3189 Cite this article as: Morris et al.: A GA microsatellite in the Fli1 prom oter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis. Arthritis ... factor Fli1 is implicated in the pathogenesis of systemic lupus erythematosus (SLE). Recently, a GA n polymorphi...

Ngày tải lên: 12/08/2014, 15:22

... 14-month-old Arab boy had clinical features typical of severe combined immunodeficiency. His clinical picture and flow cytometric analysis raised the diagnosis of adenosine deaminase deficiency and prompted ... profoundly lymphopenic and died of infection before their second birthday. In the ensuing years, differences in inheritance patterns were noted, indicating causal heterog...

Ngày tải lên: 11/08/2014, 17:21

... explained. They took the parts of the interviewer and respondent in a role-play practice and also practised doing interviews and physical measurements with the instructors and few patients. Instruments ... difficul- ties with mobility and body functioning were assessed on the following scale: “no”, “yes” and “yes with some difficulty”. Baseline pain level was ass...

Ngày tải lên: 13/08/2014, 14:20

... and diabetes, and plays a fundamental role in endothelial dysfunction associated with these diseases (1-6). Further, oxidative stress plays a major role in the pathogenesis of both types ... sustained fall in the bathroom result- ing in a left ankle fracture with vomiting and diarrhea for seven days. The patient was treated with met- formin and augmentin. U...

Ngày tải lên: 26/10/2012, 09:39

... endothelial cells, as shown by in situ hybridisation [120]. There is only scant expression of these enzymes in normal synovia. MMP-3 (stromelysin) mRNA mainly occurs in the lining layer in RA synovia ... macrophages in the RA lining layer and in the sublining, with some endothelial and lymphocyte staining [76,100–102]. The TNF receptors p55 and p75 are expresse...

Ngày tải lên: 09/08/2014, 01:23

... [8]. What is the relevance of these findings in terms of our understanding of RA? Increased angiogenesis is thought to be crucial in supplying nutrients and oxygen to the synovial tissue in RA, ... significantly lower than in individuals with inactive disease or healthy controls, and that they correlated inversely with disease activity. Moreover, treatment of patients...

Ngày tải lên: 09/08/2014, 07:20

... by the normal ac id/base status and by the negative history of drug intake. The possibility of primary hyperparathyroidism with vitamin D deficiency e xists, but the sestamibi sc an w as ne gative, ... (AAs) with a large extracellular domain and the characteristic seven-transmembrane domains [4]. It is expressed in the parathyroid gland, kidneys, bones, and other tis...

Ngày tải lên: 11/08/2014, 02:22

... variables. This finding may be related to the fact that the PK analy- ses were performed during the early phase of sepsis. Also, as a first dose of antibiotic is largely influenced by Vd, the increased distribution ... limitations in predicting the real CrCl in ICU patients [54]. Finally, the four groups were heterogeneous and, therefore, the numbers may be too small to...

Ngày tải lên: 13/08/2014, 21:20

... bradyzoites in response to the immune system attack during disease progression. They will remain in the brain and other organs during the lifetime of infected hosts. The reactivation of encysted ... bradyzoites into actively replicating and cytolytic tachyzoites can trigger a disease with severe clinical syndromes leading in many cases to the death of the patients. Wh...

Ngày tải lên: 08/03/2014, 22:20

... associates with tyrosine kinases of the Janus kinase (Jak) family. Upon ligand binding the associated Jaks become activated by transphosphorylation and phosphorylate tyrosine residues in the cytoplasmic ... spacing between the CBM and the membrane, each of the domains was replaced by the corresponding domain of the GCSFR. The replacement is assumed to compensate...

Ngày tải lên: 18/03/2014, 01:20