length blys and dblys mrna isoforms in systemic lupus erythematosus patients

... Figure BLyS protein and BLyS isoform mRNA levels in normal individuals, and RA, and SLE patients (a) Plasma from normal individuals (Nl), and RA and patients SLE patients were assayed for BLyS ... same individuals Amounts of full -length BLyS, BLyS, and actin mRNA were quantified by real-time RT-PCR, and results are shown as ratios of full -length BLyS mRNA (b) and BLyS mRNA (c) to actin mRNA ... levels of fulllength BLyS and BLyS mRNA isoforms in systemic lupus erythematosus patients Previous reports of elevated circulating BLyS levels in SLE patients were based on a BLyS ELISA that...

Ngày tải lên: 09/08/2014, 07:20

... 3) was observed in two patients from the atorvastatin group and in one from the placebo group In two atorvastatin group patients, the SLEDAI increase (from to 12 and from to points) resulted solely ... atherosclerosis in systemic lupus erythematosus: implications for patient management Curr Opin Rheumatol 2001, 13:341-344 Noel B: Risks and benefits of statins in lupus erythematosus Arch Intern Med ... ECG recordings were normal in all the patients Results of peripheral Page of blood count, serum sodium, potassium, glucose, creatinine, and urinalysis were all normal Systemic Lupus Erythematosus...

Ngày tải lên: 12/08/2014, 17:22

... chemokine ligand; CXCL, C-X-C chemokine ligand; IFIG, IFN-inducible gene; IFIT, interferon-induced protein with tetratricopeptide repeats; IL, interleukin; IP-10, interferon-inducible protein 10; ... age and sex ANA, antinuclear antibody; RA, rheumatoid arthritis; SDI, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index; SLE, systemic lupus erythematosus; ... finding that IFN-inducible chemokines may serve as a biomarker in active SLE requires verification in a larger cohort of patients, as well as in patients from different races and backgrounds In...

Ngày tải lên: 09/08/2014, 13:22

... cell-specific intercellular adhesion molecule-grabbing tegrin expression in systemic lupus erythematosus dendritic cells Dendritic cell-specific intercellular adhesion molecule-grabbing noninnonintegrin ... between MR expression and systemic lupus erythematosus Disease Activity Index (SLEDAI) scores (*r = -0.36, P = 0.006; **r = -0.48, P = 0.002) in systemic lupus erythematosus (SLE) patients (b) Correlation ... for generating and maintaining peripheral tolerance, a key component in the prevention of autoimmunity, as well as stimulating immune responses in appropriate settings [3] well as (in the case...

Ngày tải lên: 09/08/2014, 13:22

... ATP6 and CYTB were found in rheumatoid arthritis (unpublished data) Moreover, it is interesting that proinflammatory cytokines such as IL-6 and TNF, as well as anti-inflammatory cytokines including ... of increased interferoninducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus Arthritis Rheum 2006, 54:2951-2962 Lee HM, Mima T, Sugino ... cross-complementing (ERCC)2, (b) ERCC5, and (c) X-ray repair cross-complementing (XRCC)6 in peripheral blood of 21 patients with systemic lupus erythematosus (SLE) and 45 healthy individuals (HI)...

Ngày tải lên: 12/08/2014, 15:23

... cytomegalovirus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SLICC, Systemic Lupus International Collaborating Clinics aInformation for treatment was available in 19 patients in this group ... by the Institutional Review Board The present study meets and is in compliance with all ethical standards in medicine, and written informed consent was obtained from all patients according to ... Sturfelt G: The reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index in patients with systemic lupus erythematosus Arthritis Rheum 1997,...

Ngày tải lên: 09/08/2014, 01:22

... etiology of psychiatric symptoms in patients with systemic lupus erythematosus Scand J Rheumatol 1994, 23:277-282 Iverson GL: Screening for depression in systemic lupus erythematosus with the British ... Controlled Oral Word Association Test and Animal Naming Tests (total scores each) [37], and the Finger Tapping Test (dominant and nondominant hands) [32] Reliability and validity for this test battery ... citation purposes) tains 15 pain-related words divided into sensory and affective categories in a pain-rating index Individuals are asked to give each description of pain a rating from ('none') to ('severe')...

Ngày tải lên: 09/08/2014, 10:20

... from a patient with systemic lupus erythematosus (a) Anti-FDC (follicular dendritic cell) staining within the area known as germinal centre (GC) A (b) Staining for CD20 FDC staining suggests two ... subjects and patients with systemic lupus erythematosus Int Arch Allergy Immunol 2000, 123:36-45 27 de Wildt RMT, Tomlinson IM, van Venrooij WJ, Winter Ga, Hoet RMA: Comparable heavy and light chain ... within close proximity, but B-cell staining shows no clear demarcation (c) Anti-FDC staining for GC B (d) staining with anti-CD20 Panels (a) and (b) are consecutive sections, as are (c) and (d)...

Ngày tải lên: 09/08/2014, 01:21

... of lupus erythematosus patients systemic TNF stimulation on gene expression in healthy individuals Effect of TNF stimulation on gene expression in healthy individuals and and systemic lupus erythematosus ... Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... Behrendsen SC, Kubin M, Rengaraju M, Ohtsuka K, Trinchieri G: Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus Arthritis...

Ngày tải lên: 09/08/2014, 01:22

... necropsy patients Am J Med 1975, 58: 243-264 Kong TQ, Kellum RE, Haserick JR: Clinical diagnosis of cardiac involvement in systemic lupus erythematosus: a correlation of clinical and autopsy findings ... Controlling cardiovascular risk factors in systemic lupus erythematosus J Musculoskel Med 1998, 15: 42-52 El-Magadmi M, Ahmad Y, Wajed J, Bruce IN: The bimodal mortality pattern in systemic lupus erythematosus ... little reinforcement from their providers In recruiting patients with SLE and hyperlipidemia for a statin dosing study, our experience has been that the patients who are the most willing to participate...

Ngày tải lên: 09/08/2014, 01:22

... processing in patients with systemic lupus erythematosus In vivo imaging and clearance studies J Clin Invest 1992, 90:2075-2083 Sullivan KE, Wooten C, Goldman D, Petri M: Mannose-binding protein ... studied in 143 patients with SLE and 200 healthy blood donors DR3 represents the haplotype DR3-DQ2-C4AQ0 donors F, phenylalanine; H, histidine; Int, intermediate; MBL, mannan-binding lectin; R, arginine; ... in systemic lupus erythematosus Arthritis Rheum 1994, 37:1380-1385 14 Suzuki H, Matsui Y, Kashiwagi H: Interleukin-1 receptor antagonist gene polymorphism in Japanese patients with systemic lupus...

Ngày tải lên: 09/08/2014, 01:24

... For annexin-V/PI staining × 106 cells were resuspended in 50 µl binding buffer (Roche Diagnostics, Lewes, UK) and incubated with annexin-V/FITC (Roche) and annexin-V/PI (Roche) for 15 minutes at ... difference in the type of LDL present in patients and control individuals may explain our observation of an inverse correlation of TGF-β1 AI and LDL in SLE patients, which was not seen in control individuals ... TGF-β1 activation during blood clotting in patients and control individuals, and examined whether TGF-β1 activation was associated with clinical phenotype, in particular inflammatory disease...

Ngày tải lên: 09/08/2014, 08:22

... with the recombinant RPA32 protein Antibodies against RPA32 were found in 10.9% (87 of 801) in breast cancer patients and in 10.3% (4 of 39) in intraductal in situ carcinoma patients, in contrast ... single-stranded DNA-binding protein with multiple and essential roles in almost every aspect of DNA metabolism, including replication, repair, and recombination [6] Autoantibodies against RPA in rheumatic ... proteins and DNA by high NaCl and possibly secondary conformational changes help the binding of anti-RPA antibodies in autoimmune sera We examined whether the binding of DNA to RPA can interfere...

Ngày tải lên: 09/08/2014, 08:22

... transforming growth factor-β and IL-10 In addition, Gas-6 on apoptotic cells binding to receptor kinases of Tyro family (mer, tyro and axl) downregulate inflammatory cytokines, IL-12 and TNFα during ingestion, ... adaptive and innate immune systems in both responding to infections and inducing autoimmunity Theapeutic implications Toll-like receptors as therapeutic targets As data linking TLR activation and ... expect and anticipate that models of lupus in mice deleted of both TLR7 and TLR9 with provide additional insight into the potential therapeutic role of TLR9 inhibition in lupus Targeting type I interferons...

Ngày tải lên: 09/08/2014, 10:21

... horizontal lines in each box indicate median values Note that inflammatory indices are higher in SLE patients than in healthy controls or RA patients and are higher in RA patients than in healthy ... release proinflammatory cytokines and chemokines, causing local tissue damage and stimulating hypertrophy of smooth muscle cells in the artery wall Inflammation is also expanded by the influx Page ... atorvastatin 80 mg or placebo for 12 weeks The inflammatory index of patient HDLs fell 15% in statin-treated patients and rose 7% in those on placebo (P

Ngày tải lên: 09/08/2014, 10:23

... function in patients with active systemic lupus erythematosus J Immunol 2001, 166:6452-6457 Crispin JC, Martinez A, Alcocer-Varela J: Quantification of regulatory T cells in patients with systemic lupus ... cells in patients with systemic lupus erythematosus Lupus 2007, 16:489-496 Bonelli M, von Dalwigk K, Savitskaya A, Smolen JS, Scheinecker C: Foxp3 expression in CD4+ T cells of patients with systemic ... for interleukin in Foxp3-expressing regulatory T cells Nat Immunol 2005, 6:1142-1151 β Marie JC, Letterio JJ, Gavin M, Rudensky AY: TGF-β1 maintains suppressor function and Foxp3 expression in...

Ngày tải lên: 09/08/2014, 13:22

... of lupus erythematosus patients systemic TNF stimulation on gene expression in healthy individuals Effect of TNF stimulation on gene expression in healthy individuals and and systemic lupus erythematosus ... Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... Behrendsen SC, Kubin M, Rengaraju M, Ohtsuka K, Trinchieri G: Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus Arthritis...

Ngày tải lên: 09/08/2014, 13:22

... antibody-producing cells [25] Yet, it remains unknown why IL-17 production is increased in lupus and whether such a finding is related to Th1 cells producing IFN-g Determining the balance of Th17- and Th1-cell ... Infiltrates of IL-17 producing T cells, including CD4 + and DN T cells, have been found in lupus nephritis In addition, IL17 gene expression was detected in T cells infiltrating the kidneys and ... with SLE than in healthy subjects, suggesting the possible involvement of this cytokine in enhancing the Th17-cell response we observed In line with this finding, increased circulating levels of...

Ngày tải lên: 12/08/2014, 12:20

... systemic lupus erythematosus; SLEDAI: systemic lupus erythematosus disease activity index; TNF-α: tumor necrosis factor-α Competing interests The authors declare that they have no competing interests ... described in this study Our study also did not examine whether the BMDC changes were intrinsic defects or secondary to microenvironmental changes in the BM, including the cytokine milieu in our SLE patients ... findings may not be generalized to all patients with SLE, as the patients recruited in this study all had some form of cytopenia or fever requiring further investigations, including a BM examination...

Ngày tải lên: 12/08/2014, 12:20