Báo cáo y học: "Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-α and dexamethasone" pot
Báo cáo y học: "Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-α and dexamethasone" pot
... expression of CD38 in human air-way smooth muscle cells [5,7,8]. The regulation of CD38 expression by TNF-α in HASM cells involves NF-κB and AP-1 activation and signaling through the p38 and JNKBinding ... binding of NF-κB and AP-1 to putative cd38 binding sites. Dexamethasone reversed the TNF-α- induced activation of the 3 kb promoter and increased the binding of GR to consensus and putative cd38 ... NF-κB binding site and four GRE binding siteswithin the cd38 promoter. The putative transcription fac-tor binding sites on the cd38 promoter are shown in Table1. Human Airway Smooth Muscle...
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Báo cáo y học: " A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged highthroughput biophysical screening" pps
... Kayyali US, Gaestel M,Shore SA, Fredberg JJ: Role of heat shock protein 27 in cytoskeletalremodeling of the airway smooth muscle cell. Journal of AppliedPhysiology 2004, 96:1701-1713.36. Dandurand ... every 10-14 days. ASM cells in culturewere elongated and spindle shaped, grew with the typi-cal hill -and- valley appearance, and showed positivestaining for the smooth muscle -specific protein ... t-test, the Analysis of Variance (ANOVA) withadjusting for multiple comparisons by applying the Tukey’s method, or the Wilcoxon test depending on the distribution of data. To satisfy the distributionalass...
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Báo cáo Y học: Inactivation of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio alginolyticus by reactive oxygen species pot
... carried out by comparison with aCu2+standard [13].RESULTS AND DISCUSSIONInhibition and uncoupling of the Na+-NQRactivity by dioxygen In the presence of NADH and dioxygen, the purified ... already inactivated in the membrane-bound state if the cells are disrupted in the presence of dioxygen, resulting in an uncoupling of NADH oxidation and Q reduction activities. The uncoupling of the Na+-NQR ... addition of NADH in the presence of thenoyltri-fluoroacetone (TTFA), a specific inhibitor of succinatedehydrogenase and fumarate reductase, prevented the increase in signal intensity in the g %...
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Tài liệu Báo cáo Y học: Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine docx
... toxic to neurons in culture by increasing the vulnerability of these cells toexcitotoxic and oxidative injury [50]. In smooth muscle cells, homocysteine can increase production of nitric oxide ... (b-siteAPP cleaving enzyme) at the N-terminus of Ab [4,5] and by an as yet unidentified c-secretase at the C-terminus of Ab(reviewedin[6]).Ab is the main component of vascularamyloid in Alzheimer’s ... resulting in damageto the basement membrane and leading to the eventualdestruction of the cells [12]. The loss of VSMC may result in weakening of the vessel wall, its subsequent rupture and ultimately...
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Báo cáo y học: "Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation" pptx
... intense debate and remainspoorly understood. The role of the airway epithelium in modifying the contractility of the underlying smooth muscle has been suggested but is not yet fully demon-strated. ... channel in the apical membrane of secretoryepithelial cells [6]. In CF, defective function of CFTR in airway epithelial cells and submucosal glands results in chronic involvement of the respiratory ... function of CFTR in airway epithelial cells and submucosal glandsresults in chronic involvement of the respiratory tract,manifested by progressive airway obstruction that beginsearly in life...
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Báo cáo y học: "Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes" pps
... chronic inflammatory diseasecharacterized by synovial lining hyperplasia and sublining infil-tration of inflammatory cells [1]. Fibroblast-like synoviocytes(FLSs) play a crucial role in joint ... phosphorylation by anisomycin, lipopolysaccharide, and sorbitol [19,29].MKK4 and MKK7 are, in turn, regulated by a large family of ser-ine/threonine kinases known as the MAP3Ks that integrateextracellular ... in RA FLSs. Kinase assays suggested that MEKK2 and TAK1 areespecially important activators of the JNK pathway in FLSs. In the present study, we examined the hierarchy of these pro-teins in IL-1β-mediated...
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Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt
... NP cells by the action of TNF-α. DiscussionThis study investigates the effect of the pro-inflammatorycytokines IL-1β and TNF-α on catabolic gene expression in normal and degenerate IVD cells. ... Interleukin-1 receptorantagonist delivered directly and by gene therapy inhibitsmatrix degradation in the intact degenerate human interverte-bral disc: an in situ zymographic and gene therapy study.Arthritis ... strength and restrain the inner NP region. Molecular changes in degenera-tion include altered matrix synthesis, including a decrease in glycosaminoglycan production and an increase in collagentype...
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Báo cáo y học: " Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage" docx
... possibly explained by the binding of methyl-CpG-binding protein 1 complex and methyl-CpG-binding protein 2 to methylated Sp1 transcriptionfactor binding sites, thereby inhibiting the binding of ... role in shuttling of NF-κB from the nucleus and cytosol and in the bindingNF-κB in the nucleus of T cells, potentially contributing to the lower activation levels of the HIV-1 LTR and possiblypromoting ... located in the mid-frontal gyrus of the brain of infected individuals. A high rate of viral replicationoccurs in this region of the brain. Interestingly, the pres-ence of the 6G configuration of...
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Báo cáo Y học: Regulation of a1,3galactosyltransferase expression in pig endothelial cells Implications for xenotransplantation doc
... in the protein codingsequence [17–19]. The absence of a functional a1,3GalTgene copy in humans, and in apes and Old W orld monkeys,explains the absence of aGal epitopes in these species. In Correspondence ... METHODS Cells and cell linesCOS7 cells were obtained from the Netherlands CancerInstitute (Amsterdam, the Netherlands). The pig kidney cells (PK15) were obtained from A. Roos (Department of Nephrology, ... using the Prime-a-gene labeling system (Promega). Double-positiveclones were purified by secondary and tertiary r ounds of screening and genomic DNA inserts were purified usingpoly(ethylene glycol)...
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Báo cáo Y học: Regulation of peptide-chain elongation in mammalian cells pptx
... translo-cation and in poly(U)-directed polyphenylalanine synthesis[26,27], by preventing it from binding to the ribosome [28].Early data showed that the phosphorylation of eEF2 wasincreased by very low ... alsoincrease the phosphorylation of the valyl-tRNA synthetasethat associates with eEF1A/B. The available evidencesuggests that phosphorylation of eEF1A/B and of valyl-tRNA synthetase by PKC increases ... members of main protein kinasesuperfamily, Ryazanov coined the term Ôa-kinaseÕ for thisunusual group of enzymes. Further discussion of this familymay be found in a recent review by Ryazanov...
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