Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf

... (Stage I) and tiny collagen fibers in the lung of rats in the sil- ica+Lv-shCD36 group. Compared to the silica and the sil- ica+Lv-shCD36-NC groups, the number of nodules in the lungs of rats in the ... silencing expression of CD36 inhib- its activation of L-TGF-β1, which results in reduced hydroxyproline, collagen synthesis, and further preve...

Ngày tải lên: 12/08/2014, 14:20

... corresponding signature: where Q is the set of genes in the signature, n Q is the num- ber of genes in Q, x i is the expression of gene i, and w i is either -1 or +1 depending on its concordance index ... datasets in our survival analysis, we kept only the common genes between these two platforms (10,540 genes); we kept 10% of the genes for which the varia...

Ngày tải lên: 09/08/2014, 20:21

... tension and cell-ECM interactions. Our results and those of others demonstrate the complex regulatory network that exists in the developing lung, and how the myofibroblast plays a key role in driving ... cells. The inset in D (secondary antibody only) shows minimal levels of Alexa Fluor-568 staining in the absence of the primary antibody. Scale bars are 20...

Ngày tải lên: 12/08/2014, 14:20

... genes in our study appeared in one or more of the lists of genes identified as being involved in immunity in the microbial pathogen studies in adults, and only 8-10% of the genes in our study were ... associations between the serpent/ GATA-type motifs and the genes in cluster 2, many of which had been annotated as being involved in immunity, and the R...

Ngày tải lên: 14/08/2014, 15:20

... patterns of expression between the retina, brain, and mouse platform were determined by miR microarray profiling. The results of the study suggest that the relative magnitude in expression of widely ... upregulated, expression of their targets may possibly be suppressed in P347S mice. Many genes encoding factors that are involved in mRNA processing and splici...

Ngày tải lên: 14/08/2014, 08:20

... 4). Protein Fingerprint Analysis of Serum Samples in Patients with CRC and Healthy Controls The protein profile of the serum samples from the 98 patients with CRC and the 80 healthy controls ... tool for integrating separation and analysis of complex mixtures of proteins. Captured proteins are then analyzed by TOF-MS, generating a spectral map depicting approximatio...

Ngày tải lên: 25/10/2012, 11:18

... Proline, hydroxyproline and hydroxylysine were examined at 254 nm by reverse-phase HPLC of their phenylisothiocarbamate derivatives [26], as reported previously [20]. The serine, threonine and tyrosine contents ... Hydroxyproline, hydroxy- lysine and phosphoserine were not detected in WSM, WIM, EDTA-SM and EDTA-IM. The comparison of the amino acid composition of the ma...

Ngày tải lên: 21/02/2014, 01:21

... alternate interpretation of the lack of agonist-induced BRET observed in this study is that the translation of agonist binding to the ATDs of the family C GPCR homodimer into G-protein coupling of the ... 2002 Agonist-induced rearrangement of the 7TMs in the CaR homodimer? One of the goals of the present study was to investigate, whether the activating...

Ngày tải lên: 08/03/2014, 09:20

... non-inflammatory conditions [2]. Most chemokines play a role in inflammatory conditions by inducing integrin activation, chemotaxis, and angiogenesis. Apart from modulating migration directly, ... abundant expression of a variety of inflammatory chemokines and their receptors [5,6]. In vitro studies have suggested that both so-called homeostatic chemokines and inflammatory ch...

Ngày tải lên: 09/08/2014, 01:23

... processes underlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAH increases the importance ... vasculopathy of SScl may also be modifiable. In the characteristic microangiopathy of SScl, luminal narrowing results from a combination of intimal pro...

Ngày tải lên: 09/08/2014, 06:23