Báo cáo y học: "Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells" doc

... but significant effects in patients with pulmonary arterial hypertension. In this study we explored the molecular effects of statins on distal human pulmonary artery smooth muscle cells (PASMCs) ... [ 3 H-methyl]-thymidine incorporation, by statins with rank-order of potency simvastatin = fluvastatin > atorvastatin >> pravastatin. (C-D) Effect of NO...

Ngày tải lên: 12/08/2014, 14:20

... variety of cytokines and inflammatory media- tors, especially in asthma airway remodeling. IL-13 is an important Th2 lymphocyte proinflamma- tory factor [18,19] that also plays an important role in chronic ... contributed to their secretory and hyperproli- ferative phenotype in asthma, suggesting that SERCA2 may play a key role in mechanisms of airway remodeling [12]. In our stu...

Ngày tải lên: 11/08/2014, 03:20

... contributed to their secretory and hyperproli- ferative phenotype in asthma, suggesting that SERCA2 may play a key role in mechanisms of airway remodeling [12]. In our study, using an asthmatic rat model ... Yang Abstract Airway remodeling and airway hyper-responsiveness are prominent features of asthma. Neurogenic inflammation participates in the development of asthma. Neurokin...

Ngày tải lên: 11/08/2014, 06:23

... index of proliferation (IOP) of perivascular cells in monocrotaline (MCT) model of pulmonary hypertension. In situ proliferation of perivascular cells in rat lungs was investigating by using immunostaining ... dose of 30 mg/kg of BW/day impaired the progression of PH, as evident from significantly improved hemodynamics, RV hyper- trophy and remodelling and pulmonary va...

Ngày tải lên: 12/08/2014, 13:22

... µg/ Phosphodiesterase type 4 (PDE4) expression in human pul-monary artery smooth muscle cellsFigure 1 Phosphodiesterase type 4 (PDE4) expression in human pulmonary artery smooth muscle cells. RT- PCR ... monocrota- line- [43] and hypoxia-induced rat models of pulmonary hypertension [15], the anti-proliferative effects of iloprost in vivo being potentiated by th...

Ngày tải lên: 12/08/2014, 16:20

... placenta. Among the 16 coding env genes of the human genome tested in [8], only two, namely envW (syncytin-1) and env- FRD (syncytin-2), had been found to be fusogenic in an ex vivo assay. As these two ... protein motif and on the HERV families described in Repbase, has revealed 16 fully coding enve- lope genes, transcribed in several healthy tissues [5,6], among which two (syncyt...

Ngày tải lên: 13/08/2014, 09:21

... pulmonary artery in the absence of conotruncal anomalies. An epo- prostenol (prostacyclin) infusion was instrumental in lowering pulmonary artery pressures and stabilizing the child prior to surgery. Case ... demonstrated, and a distal pulmonary artery was faintly visible at the level of the hilum. During sur- gery, an aortopulmonary collateral artery supplying the rig...

Ngày tải lên: 11/08/2014, 12:20

... chromatin and thereby the DNA is exposed to highly reactive ROS which induce single strand breaks in the DNA. In cells, generally, these toxic effects are eliminated by repair enzymes. Poly-(ADP-ribose)-polymerases ... insight into the proportionality between the duration of activation and the increase of fluorescence in- tensity inside of the nuclei of DU145 cells....

Ngày tải lên: 25/10/2012, 11:15

... behavior of LMVs composed of dimyristoylglycerophosphocholine (Myr 2 Gro-PCho), dimy- ristoylglycerophosphoethanolamine (Myr 2 Gro-PEtn) and dimyristoylglycerophosphoglycerol (Myr 2 Gro-PGro) by DSC, ... readily incorporate into Myr 2 Gro-PGro bilayers in the liquid-crystalline state and remain incorporated in the gel state. Permeabilization of phospholipid bilayers by GS ring-size...

Ngày tải lên: 21/02/2014, 01:21

... Zhang,L.,Ahvazi,B.,Szitner,R.,Vrielink,A.&Meighen,E. (1999) Change of nucleotide specificity and enhancement of cat- alytic efficiency in single point mutants of Vibrio harveyi aldehyde dehydrogenase. Biochemistry 38, 11440–11447. 33. ... Deyashiki, Y. , Hara, A. & Mitsui, Y. (1998) Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A ˚ resolut...

Ngày tải lên: 22/02/2014, 04:20