Báo cáo y học: "Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice" pot

... and collagen-induced arthritis in mice Shoko Toyama 1 , Naoto Tamura* 1 , Kazuhiko Haruta 2 , Takeo Karakida 3 , Shigeyuki Mori 2 , Tetsuo Watanabe 2 , Takao Yamori 4 and Yoshinari Takasaki 1 Abstract Introduction: ... signal-regulated kinase pathways are involved in osteoclast differentiation. Bone 2002, 30:71-77. 15. Nakamura I, Takahashi N, Sasaki T, Tanaka S, Udagawa N, Mu...

Ngày tải lên: 12/08/2014, 12:20

... remaining subjects easily ran 7.5 km outdoors in sunny conditions at about 32°C. Statistical Analysis Standard statistical methods were employed for the calculation of means and standard deviations ... Mourtzakis M, Saltin B, Graham T, Pilegaard H: Carbohydrate metabolism during prolonged exercise and recovery: Interactions between pyruvate dehydrogenase, fatty acids and amino acids...

Ngày tải lên: 11/08/2014, 23:21

... T, Katagiri H, Kanegae Y, Takayanagi H, Sawada Y, Yamamoto A, Pando MP, Asano T, Verma IM, Oda H, et al.: Recip- rocal role of ERK and NF-κB pathways in survival and activa- tion of osteoclasts. ... rats with collagen-induced arthritis (CIA) at day 35Histological analysis in the ankle joints of rats with collagen-induced arthritis (CIA) at day 35. Samples were stain...

Ngày tải lên: 09/08/2014, 08:22

... observation of the suppression of HAV IRES- mediated transl ation by amantadine and IFN-alpha. Sup- pression effects at 48 h after transfection by the combina- tion of amantadine and IFN-alpha against ... were evaluated with ELISA. Sup- pression of HAV replication by the combination of amantadine and IFN-alpha was stronger than those of amantadine alone, IFN-alpha alone,...

Ngày tải lên: 12/08/2014, 01:21

... KillerRed and its fusions proteins KRED-Lamin B1 and H 2A- KRED. We demonstrated their physical maps as well as their intracellular lo- calization and their resulting effects as discussed by Waldeck ... ultraviolet or ionizing radiation [6]. Observations of the Gerschman and the Harman groups reach bac k to the early 1950s and led to the assumption for a rela- tionship b...

Ngày tải lên: 25/10/2012, 11:15

... have demonstrated that volvatoxin A consists of volvatoxin A2 and volvatoxin A1 , and the hemolytic activity of volvatoxin A2 is completely abolished by volvatoxin A1 at a volvatoxin A2 ⁄ volvatoxin ... Institute of Molecular Biology Academia S inica, Taipei, Taiwan Volvatoxin A (VVA) has been isolated from Volvari- ella volvacea, and consists of volvatoxin A2 (VVA2)...

Ngày tải lên: 19/02/2014, 06:20

... Data acquisition and analysis was carried out using MICROCAL DA -2 (MicroCal LLC, Northampton, MA, USA) and ORIGIN software (OriginLab Corporation, Northampton, MA, USA). Samples containing the GS ring-size ... produces a considerably larger decrease in the temperature, enthalpy and cooperativity of the main phase transition and induces the presence of a second transition at...

Ngày tải lên: 21/02/2014, 01:21

... 7. At pH 7.5 (Fig. 7A) , the majority of the PLB are in the form of highly ordered paracrystalline arrays based on networks of interconnected tubular tetrapodal membrane units forming a bicontinuous ... organization of prolamellar bodies of maize ( Zea mays ) Eva Selstam 1 , Jenny Schelin 1 , Tony Brain 2 and W. Patrick Williams 2 1 Umea ˚ Plant Science Center, Department o...

Ngày tải lên: 22/02/2014, 04:20

... incorporated into cellular glycerophospholipids by a distinct pathway. Free AA is initially converted to AA-CoA by AA-CoA synthe- tase (a) [46]. Inhibitors of AA-CoA synthetase prevent AA incorporation ... doi:10.1046/j.1432-1033.2002.03070.x AA-CoA synthetase, inhibition of CoA-IT results in an increase in free AA and a corresponding build-up of AA in triacylglycerols that...

Ngày tải lên: 22/02/2014, 07:20

... determine whether overexpression of TGF-β1 had effects on cartilage metabolism in naïve and AIA rabbit joints, GAG synthesis by articular cartilage and GAGs released into synovial fluid as a result ... and debilitating joints, with progressive degrada- tion of cartilage and bone accompanied by proliferation of the synovium [12]. Rheumatoid arthritis remains incurable...

Ngày tải lên: 09/08/2014, 01:21