Báo cáo y học: "Chronic arthritis leads to disturbances in the bone collagen network" pps

... determines the topography and extent of the deposition of hydroxyapatite bone min- eral in the extracellular bone matrix. Collagen further influences the elasticity of bone and is mainly responsible for ... that bone in arthritic animals has a higher remodeling rate, the increase in the bone- forming marker PINP being particu- larly evident, suggesting that an act...

Ngày tải lên: 12/08/2014, 11:22

... and their relative contributions to the weakness may vary considerably when this occurs. Elevated serum creatine kinase may help to identify CIM, but the peak may be missed in the membranopathy/necrotizing ... ventilatory failure in the intensive care unit. CK, creatine kinase; CSF, cerebrospinal fluid; GBS, Guillain–Barré syndrome; EMG, electromyography; MRI, magnetic resonan...

Ngày tải lên: 12/08/2014, 20:20

... 3A; arrow-indicated in (b)), P63 was detected in the cytoplasm of cells in the HGPIN (high grade PIN) lesions (Figure 3A; arrow-indicated in (c)) and CaP (Figure 3A; arrow- indicated in (d)). Interestingly, ... cytoplasm (Figure 2H to 2J and 2M to 2O). Moreover, Hh signal ing proteins were expressed hetero- geneously, i.e. only in some cell lineages of the PIN lesions (F...

Ngày tải lên: 10/08/2014, 05:21

... elevated. During laparotomy, a 5 cm mass was found posterior to the rectum and anterior to the sacrum, extending between the an al sphincters (Figure 3). The tumour was mobilised easily by incising the ... Apostolidis 2 , Despoina Televantou 3 , Prodromos Hytiroglou 3 Abstract Introduction: Teratomas of the sacrococcygeal area are usually diagnosed in infancy and are rarely...

Ngày tải lên: 11/08/2014, 14:21

... chemically synthesized methylcitrate revealed a 10-fold decrease in activity. This may also explain the higher relative activities obtained in the former study with substrates other than methylcitrate. The ... than methylcitrate. The necessary syn elimination of water performed by PrpD may be the reason why this reaction cannot be catalysed by aconitase. Furthermore, aconitase e...

Ngày tải lên: 17/03/2014, 10:20

... CHB/myocarditis with varying degrees of pathology parallel the results obtained exploiting in vitro coculturing systems. Physiologic apoptosis may initiate an inflammatory process via antibody binding ... entirely independent of whether the mother has systemic lupus erythematosus or Sjögren’s syndrome, or is totally asymptomatic [3,4]. One of the most intriguing aspects of CHB is that...

Ngày tải lên: 09/08/2014, 01:22

... within the inflammatory infiltrates in the joints of the CCR2 –/– mice [19]. Data from the knockout mice suggest that at least some individual inflammatory chemokine receptors are pivotal in the ... modulating migration directly, chemokines can stimulate cells to release (pro)inflammatory mediators such as cytokines and matrix metalloproteinases [3]. Increased expression of in...

Ngày tải lên: 09/08/2014, 01:23

... clinical entity. At the very least, the joint disease in PsA is modified by the presence of Ps to produce a form of SpA with easily distinguished clinical features. Again, this supports the final conclusion ... the SpA family, and the focus should be on trying to identify features, perhaps common to the target tissues (skin, synovium and enthesis), which are specific for...

Ngày tải lên: 09/08/2014, 06:23

... the combinations of various proin- flammatory cytokines or other factors together with GM-CSF in the SF may be involved in RA pathogenesis in vivo. To address the effects of GM-CSF in SF on the ... growth factors in the RA joint microenvironments. To identify factors having an effect on the growth of RA FLSs, we investigated the inflam- matory cytokines and growth...

Ngày tải lên: 09/08/2014, 08:23

... a reduction in the elastic restraint of the collagen network, allowing the glycosaminoglycans within the fibrillated tissue to swell to a greater degree of hydration [28]. Because the speed of ... Site-specific differences in signal intensity suggest that the superficial col- lagen network may be maintained in cartilage of the lateral condyle but may deteriorate in...

Ngày tải lên: 09/08/2014, 10:23