Báo cáo y học: "A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis" ppsx

... http://arthritis-research.com/content/11/6/R180 Page 1 of 10 (page number not for citation purposes) Vol 11 No 6 Research article A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid ... 1 The flow sheet of production of chicken type II collagen (CCII)The flow sheet of production o...

Ngày tải lên: 12/08/2014, 11:22

... results of a multicenter, randomized, double-blind, placebo -controlled, phase III trial evaluating pri- mary efficacy and safety at twenty-four weeks. Arthritis Rheum 2006, 54:2793-2806. 10. Finckh ... respectively. Clinical trials confirmed the efficacy in switching to abatacept (gain of effect 10.2%). Tocilizumab allows DAS28 (DAS using 28 joint counts) remission in 3...

Ngày tải lên: 09/08/2014, 14:22

Ngày tải lên: 09/08/2014, 10:22

... cells; CAIA: collagen antibody induced arthritis; CII: collagen type II; CIA: collagen induced arthritis; CTLL: murine T cell line; DC: dendritic cells; DTH: Delayed -Type Hypersensitivity response; ... inflammatory effector phase in CIA. Enhanced delayed type 1 hypersensitivity (DTH) reaction response in cystatin C-deficient mice Since cystatin C-deficiency did not alter th...

Ngày tải lên: 12/08/2014, 15:22

... 90-day clinical study, we also assessed the safety of 5-Loxin ® in OA patients. Pain, stiffness of joints, reduced joint movement and physical disability are the major clinical manifestations of ... analysis Analysis Details Serum biochemistry Albumin Alkaline phosphatase Total bilirubin Cholesterol Creatinine Creatine kinase-N-acetyl cysteine Glucose High-density lipoprotein Low-...

Ngày tải lên: 09/08/2014, 10:23

... groups. Following 24 hours of administration of IV ibuprofen, no clinically significant differences in any safety parameter including renal function or bleeding occurred through the 28-day follow-up ... 14:R125 http://ccforum.com/content/14/3/R125 Page 7 of 13 In a secondary analysis of efficacy, the efficacy of IV ibuprofen was analyzed by assessing the percentage of treatm...

Ngày tải lên: 13/08/2014, 21:20

... standard. RESULTS Induction of citral lyase Initially, the reproducibility of the results was hindered by variations in the citral lyase activity of the P. digitatum spores. Remarkably, lyase activity was ... citral lyase could be induced in the nonger- minating spores of P. digitatum. To the best of our knowledge, the induction of an enzymatic activity in nongerminating spo...

Ngày tải lên: 21/02/2014, 01:21

... phosphotyrosines bind to the phosphotyrosine binding pocket of the SH2 domain, with R94 only playing a minor role in the binding of these peptides. DISCUSSION The cytoplasmic part of the EpoR contains ... tyrosines in the context of SOCS-binding we deter- mined binding affinities of SOCS-3 to peptides containing only phosphotyrosine pY429 or pY431, as well as a double- phosphoryl...

Ngày tải lên: 24/03/2014, 00:21

... analyzed off-line in a Biflex III (Bruker Daltonics, Bremen, Germany) MALDI-TOF instrument in positive ion mode as described previously [6]. External calibration was performed using angiotensin II ... of birtoxin (Fig. 4). In ikitoxin the presence of Glu23 charge preceding the a-helix modifies the activity of this toxin in a unique way to result in reduced potency in mice....

Ngày tải lên: 31/03/2014, 08:20

... Int. J. Med. Sci. 2008, 5 67 such as dihydroxyvitamin D3 (calcitriol), that increase PSADT without concomitantly decreasing PSA and yet become clinically valuable when used in combination ... months and 11 continued for at least 1 year with one patient continuing for more than 2 years. Therapy was not discontinued in any patient due to vitamin toxicity or for other safety reasons...

Ngày tải lên: 08/08/2014, 17:20