Báo cáo y học: "The role of pleiotrophin and β-catenin in fetal lung development" doc

... Wnt signaling in adult lung causes lung cancer, fibrosis, and inflammation [109]. Hyperactivation of β-catenin, caused by mutations of β-catenin, APC, and axin in lung epithelium induces lung tumors ... W, Yamin M, Noda M, et al.: Pleiotrophin signals increased tyrosine phosphorylation of beta beta- catenin through inactivation of the intrinsic catalytic activity...

Ngày tải lên: 12/08/2014, 11:22

... derivative of 8-phe- nyltheophylline (8-PT, 8-(p-sulphophenyl)-theophylline (8-SPT) (Research Biochemicals Inc.), to the arterial and venous perfusate. Single HA doses of acetylcholine (ACh, 10 -7 ... inhibi- tion of HA responses by 8-SPT between intra-arterial and intra-portal injection of ATP despite a longer lag-time between injection and response following intra-portal injec...

Ngày tải lên: 13/08/2014, 13:20

... evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... intracellular domain of the Notch receptor (involved in the maintenance of cells in an undifferentiated state), both of which notably contain ankyrin repeat motifs conta...

Ngày tải lên: 09/08/2014, 01:22

... [29], in chronically inflamed skin in a Leishmania infection model [30], and in the mucosa and mesenteric lymph nodes in inflammatory colitis in severe combined immunodeficient (SCID) mice [31]. Interestingly, ... allophycocyanine or FITC-conjugated anti-CD25 (PC61), streptavidin-allophycocyanine and streptavidin-PE, and matched antibody pairs for ELISPOT analysis of IFN-γ...

Ngày tải lên: 09/08/2014, 06:22

... intracellular domain of the Notch receptor (involved in the maintenance of cells in an undifferentiated state), both of which notably contain ankyrin repeat motifs containing the asparagine residue hydroxylated ... small interfering RNA against PHD-1 or PHD-2 or the pan-hydroxylase inhibitor dimethyloxalylglycine (a 2-OG analogue, and an inhibitor of both PHD and FIH) resulted...

Ngày tải lên: 09/08/2014, 13:22

... during influenza infection suggests that it may play an impor- tant role in immune signaling [101]. Deletion of TLR3 leads to downregulation of inflammatory cyt okine and chemokine production and ... confer hypersusceptibility, increased lung bacterial load, and deficient neutrophil recruitment [114,117-123]. Interestingly, MyD88 may play an essential role only during the ea...

Ngày tải lên: 11/08/2014, 03:20

... Rheumatology, Albert Einstein College of Medicine, Forchheimer 701N, 1300 Morris Park Avenue, Bronx, NY 10461, USA 3 Department of Microbiology and Immunology, Albert Einstein College of Medicine, ... identified α-actinin in mesangial cells as a plausible candidate in murine lupus. Furthermore, high titers of anti-α-actinin antibodies were present in the serum and kidney elu...

Ngày tải lên: 12/08/2014, 11:22

... growth kinetics in the nasopharynx, trachea, lungs and blood, development of lung pathology and host inflammatory leukocyte infiltra- tion into lungs was compared in both strains of mice fol- lowing ... colonisation of the upper and lower respiratory tract, and infiltration patterns of leukocytes into the lungs of infected mice were affected by the absence of SP-D. P...

Ngày tải lên: 12/08/2014, 18:20

... willingness and ability to care for trauma patients. Residency training in Emergency Medicine in the US requires a minimum of 36 months of training in an accredited residency. Training must include ... training in Emergency Medicine but maintained the primary role of surgeons as "captain of the ship" in trauma care [4,16]. Current standards for Level I trauma c...

Ngày tải lên: 13/08/2014, 23:20

... transposons Ty1- Ty4 tend to integrate into regions upstream of genes tran- scribed by RNA polymerase III (Pol III) and, in the case of Ty3, it has been demonstrated that interactions between Ty3 integration ... shown by Bachman et al. [36], the Ty1 element pref- erentially inserts into upstream regions of specific members of t Gly and t Thr genes, leading to a biased genomic di...

Ngày tải lên: 14/08/2014, 16:21