Báo cáo y học: "The role of pleiotrophin and β-catenin in fetal lung development" doc

... Wnt signaling in adult lung causes lung cancer, fibrosis, and inflammation [109]. Hyperactivation of β-catenin, caused by mutations of β-catenin, APC, and axin in lung epithelium induces lung tumors ... W, Yamin M, Noda M, et al.: Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein ... Perez-Pinera P, Deuel TF: Fyn is a downstream target of the pleiotrophin/ receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin. ...

Báo cáo y học: "The role of ATP and adenosine in the control of hepatic blood flow in the rabbit liver in vivo" pps

... derivative of 8-phe-nyltheophylline (8-PT, 8-(p-sulphophenyl)-theophylline(8-SPT) (Research Biochemicals Inc.), to the arterial and venous perfusate. Single HA doses of acetylcholine (ACh,10-7 ... inhibi-tion of HA responses by 8-SPT between intra-arterial and intra-portal injection of ATP despite a longer lag-timebetween injection and response following intra-portalinjection of ATP. This ... changes in hepatic arterial flow (∆ HAF) in vivoFigure 3The effect of intra-portal injection of (a) ATP and (b) adenosine on changes in hepatic arterial flow (∆ HAF) in vivo. Both agents increased...

Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt

... evidence for hypoxia in inflammatory and destructive joint disease, and discusses theinterplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... intracellulardomain of the Notch receptor (involved in the maintenance of cells in an undifferentiated state), both of which notablycontain ankyrin repeat motifs containing the asparagineresidue hydroxylated ... tenosynovium and from jointsynovium, and we found that oxygen in invasive teno-synovium was 43% lower than in matched joint synovium, and 28% lower than in matched encapsulating teno-synovium....

Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc

... [29], in chronically inflamed skin in a Leishmaniainfection model [30], and in the mucosa and mesentericlymph nodes in inflammatory colitis in severe combinedimmunodeficient (SCID) mice [31]. Interestingly, ... allophycocyanine or FITC-conjugatedanti-CD25 (PC61), streptavidin-allophycocyanine and streptavidin-PE, and matched antibody pairs for ELISPOTanalysis of IFN-γ (R4-6A2 and biotinylated XMG1.2) and ... with111 In and injected intravenously into AIA mice 7 days afterFigure 3Analysis of in vivo and ex vivo immune responses in CD25-depleted miceAnalysis of in vivo and ex vivo immune responses in CD25-depleted...

Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" pps

... intracellulardomain of the Notch receptor (involved in the maintenance of cells in an undifferentiated state), both of which notablycontain ankyrin repeat motifs containing the asparagineresidue hydroxylated ... small interferingRNA against PHD-1 or PHD-2 or the pan-hydroxylaseinhibitor dimethyloxalylglycine (a 2-OG analogue, and aninhibitor of both PHD and FIH) resulted in NF-κB activationvia serine ... tenosynovium and from jointsynovium, and we found that oxygen in invasive teno-synovium was 43% lower than in matched joint synovium, and 28% lower than in matched encapsulating teno-synovium....

Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf

... duringinfluenza infection suggests that it may play an impor-tant role in immune signaling [101]. Deletion of TLR3leads to downregulation of inflammatory cyt okine and chemokine production and ... confer hypersusceptibility,increased lung bacterial load, and deficient neutrophilrecruitment [114,117-123]. Interestingly, MyD88 mayplay an essential role only during the early phase of infec-tion ... T LRsignaling. In addition to TLRs, a variety of other PRRs includingthe cytoplasmic NLRs and RLRs play important roles in the induction of lung inflammation. For example, the cyto-plasmic...

Báo cáo y học: "α The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis" pot

... Rheumatology, Albert Einstein College of Medicine, Forchheimer 701N, 1300 Morris Park Avenue, Bronx, NY 10461, USA3Department of Microbiology and Immunology, Albert Einstein College of Medicine, ... identified α-actinin in mesangial cells as a plausible candidate in murine lupus.Furthermore, high titers of anti-α-actinin antibodies werepresent in the serum and kidney eluates of LN mice [8]. ... in serum anti-α-actinin antibodies in lupus patientswas associated with a 2.5-fold increase in the prevalence of LN [14]. Finally, levels of anti-α-actinin antibodies correlatedwith those of...

Báo cáo y học: " The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during " doc

... growth kinetics in thenasopharynx, trachea, lungs and blood, development of lung pathology and host inflammatory leukocyte infiltra-tion into lungs was compared in both strains of mice fol-lowing ... colonisation of the upper and lower respiratorytract, and infiltration patterns of leukocytes into the lungs of infected mice were affected by the absence of SP-D. Pul-monary clearance of intranasally ... components of both the innate and adaptiveimmune system to come into play. In the present study weassessed the in vivo contribution of SP-D to host defenceby intranasally infecting SP-D-deficient and...

Báo cáo y học: "The role of emergency medicine physicians in trauma care in North America: evolution of a specialty" pps

... willingness and ability to care for trauma patients.Residency training in Emergency Medicine in the USrequires a minimum of 36 months of training in anaccredited residency. Training must include ... training in Emergency Medicinebut maintained the primary role of surgeons as "captain of the ship" in trauma care [4,16]. Current standards forLevel I trauma center accreditation in ... but remains thestandard document describing the resources required foroptimal care of trauma patients.As early as 1966 the role of physicians staffing emergencyrooms in the care of trauma...

Báo cáo y học: "The role of transposable element clusters in genome evolution and loss of synteny in the rice blast fungus Magnaporthe oryzae" pdf

... transposons Ty1-Ty4 tend to integrate into regions upstream of genes tran-scribed by RNA polymerase III (Pol III) and, in the case of Ty3, it has been demonstrated that interactions between Ty3integration ... shown by Bachman et al. [36], the Ty1 element pref-erentially inserts into upstream regions of specific members of tGly and tThr genes, leading to a biased genomic distribution of Ty1. Analysis ... gene coding sequences. Recom-bination rate was measured by identifying the physical loca-tions of nine genetic markers on the chromosome and usingthem as a basis for delineating eight intervals...

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