... control was maintained in a standard incubator with 21% O 2 . The normoxia data are the same as shown in Fig. 1 and are included here for comparison. Expression of miR-2 7a and miR-27b at the indicated ... overexpression, indicating that miR-27 does not play an important role in myogenic differentiation. Taken together, these results illustrate a critical and specific r...
Ngày tải lên: 18/02/2014, 08:20
... 945 The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation Heath Ecroyd and John A. Carver School of Chemistry and ... signifi- cantly increased the chaperone activity of aB-crystallin (84 ± 4%) against this target protein. The effect of Arg-HCl on the...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf
... in catalysis. Abbreviations AAP, Aeromonas proteolytica aminopeptidase; blLAP, bovine lens leucine aminopeptidase; Leu-pNA, leucine-para-nitroanilide; SGAP, Streptomyces griseus aminopeptidase. 3864 ... ami- nopeptidase [(blLAP) EC 3.4.11.1] [31–34]. Based on biochemical and structural data, a general catalytic mechanism was proposed for aminopeptidases that involves an acidic...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... models or in the surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure and the structure of exchanging BS-RNase (1BSR) ... Nter are the C-terminal and N-terminal structural regions, respectively, of the two A and B monomers of the dimeric RNase. The black circle betw...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide pdf
... substrate binding sites. In the case of the titin and twitchin kinases, the autoinhibitory sequence acts as a pseudo- substrate, occluding ATP binding and preventing protein substrates from binding ... CaM. However in PhK5 Trp357 is found at the C-terminal end of the peptide. This suggests that either PhK5 might bind with Trp357 in the N-terminal site in CaM, or...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... (2005) 16 2 516 38 ê 2005 FEBS 16 31 The role of N-glycosylation in the stability, trafficking and GABA- uptake of GABA- transporter 1 Terminal N-glycans facilitate efficient GABA- uptake activity of the GABA ... N-linked oligosaccharide side-chains are important for the GABA transport activity. 1- Deoxymannojirimycin inhibits the GA...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: Improving Classification of Medical Assertions in Clinical Notes" pdf
... system. 4.1 Data The training set includes 349 clinical notes, with 11,967 assertions of medical problems. The test set includes 477 texts with 18,550 assertions. These assertions were distributed ... the training data to measure the impact of each of the four subsets of features explained in Section 3. Ta- ble 3 shows the cross validation results when cu- mulatively...
Ngày tải lên: 20/02/2014, 05:20
Tài liệu Báo cáo khoa học: "Topological Ordering of Function Words in Hierarchical Phrase-based Translation" pdf
... N N = 2048 N = 128 N = 64 N = 2048 331 Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 324–332, Suntec, Singapore, 2-7 August 2009. c 2009 ACL and AFNLP 1
Ngày tải lên: 20/02/2014, 07:20
Báo cáo khoa học: Epitope mapping of the O-chain polysaccharide of Legionella pneumophila serogroup 1 lipopolysaccharide by saturation-transfer-difference NMR spectroscopy pot
... FEBS 2002 Epitope mapping of the O-chain polysaccharide of Legionella pneumophila serogroup 1 lipopolysaccharide by saturation-transfer-difference NMR spectroscopy Oliver Kooistra 1 , Lars Herfurth 2 , ... characterization of a locus responsible for O-acetylatio n of the O -polysaccharide of Legionella pneumophila serogroup 1 lipopolysaccha...
Ngày tải lên: 08/03/2014, 10:20
Báo cáo khoa học: "Parentage testing of Thoroughbred horse in Korea using microsatellite DNA typing" pdf
Ngày tải lên: 07/08/2014, 18:21
Báo cáo khoa hoc:" Genetic parameters of dairy traits in the Alpine and Saanen goat breeds" pptx
... somewhat higher in the Alpine breed and the potential for joint progress in FC and milk and fat yields might be somewhat higher in the Saanen breed: in the Alpine breed, ... Caprigene France for financial support and the CTIG for provid- ing the data. Note Genetic parameters of dairy traits in the Alpine and Saanen...
Ngày tải lên: 09/08/2014, 18:21
báo cáo khoa học: " Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation" ppsx
... 11:23 http://www.biomedcentral.com/1471-2229/11/23 Page 9 of 13 METH O D O LOG Y AR T I C LE Open Access Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation John ... of different environmental factors. Results: We implement a more robust nonparametric covariance estimator to model these interac...
Ngày tải lên: 11/08/2014, 11:21
báo cáo khoa học: " Association mapping of common bacterial blight resistance QTL in Ontario bean breeding populations" docx
... Access Association mapping of common bacterial blight resistance QTL in Ontario bean breeding populations Chun Shi 1 , Alireza Navabi 1,2* and Kangfu Yu 1 Abstract Background: Common bacterial blight ... application of association mapping in QTL discovery using plant breeding populations could help integrate the process of QTL discovery with plant...
Ngày tải lên: 11/08/2014, 11:21
báo cáo khoa học: " Genetic mapping of wild introgressions into cultivated peanut: a way toward enlarging the genetic basis of a recent allotetraploid" docx
... mapping of wild introgressions into cultivated peanut: a way toward enlarging the genetic basis of a recent allotetraploid Daniel Foncéka 1 , Tossim Hodo-Abalo 2,3 , Ronan Rivallan 1 , Issa ... result indicates that A. duran- ensis and A. ipaiensis are more closely related to the A and the B genomes of the cultivated species than are A. carde-...
Ngày tải lên: 12/08/2014, 03:21
báo cáo khoa học: " QTL mapping of agronomic traits in tef [Eragrostis tef (Zucc) Trotter]" pdf
... morphological traits were assessed across eight different locations in Ethiopia during the growing seasons of 1999 and 2000. Using composite interval mapping and a linkage map incorporating 192 loci, 99 QTLs ... measurement of crushing strength in 1 st internode f measurement of crushing strength in 2 nd internode *** The analysis of variance for traits among lines and...
Ngày tải lên: 12/08/2014, 05:20