Báo cáo khoa học: "Enhanced anti-HCV activity of interferon alpha 17 subtype" ppt

... homology of the 5’ and 3’ UTRs among all genotypes of HCV, the efficiency of RNA genome replication of different HCV strains in the cell culture varies significantly [13]. Some strains of HCV with ... 7:36 http://www.virologyj.com/content/7/1/36 Page 11 of 16 expression of this JFH1-GFP chimera was seen in Huh- 7.5 cells 24 h after transfection. The expression of GFP in the tr...

Ngày tải lên: 12/08/2014, 04:21

... http://www.virologyj.com/content/6/1/70 Page 3 of 10 (page number not for citation purposes) Determination of anti-HCV efficacy Huh7 cells were infected with JFH-1 at a multiplicity of infection (MOI) of 0.001. After three weeks of infection, chronically ... a net charge of 0 and IFN α8 and IFN 17 both have a net charge of 3. The replacement of IFN α2's tail by an IFN...

Ngày tải lên: 12/08/2014, 04:21

... from the inset data. Plots of percent- age control activity versus concentration of inhibitor were used to determine the concentrations that inhibited 50% of protease activity. The enzymes evaluated, ... the processing of apicoplast protein leader sequence. Inhibition of any of these activities could contribute to MA interference in the maturation of the parasite. Polypharmac...

Ngày tải lên: 14/02/2014, 14:20

... hydrogenase-2 activity because assembly of the enzyme is disrupted; however, co- expression of active torD restores the Tat proofreading of this enzyme and so rescues hydrogenase-2 activity in ... assay measuring the effect of compe- tition of a ten-fold excess of XMP on the GTPase activities of the native protein and the TorD D68N vari- ant. The GTPase activity of TorD...

Ngày tải lên: 16/02/2014, 09:20

... recognition of p NPP by the pNPP site at t he rear su rface of the N -domain is due the formation of an hydrogen bond of the NO 2 -group of pNPP with the amino group of N398. The hydrophobicity of the ... optimized. Results Effects of truncation of the cytoplasmic H 4 -H 5 loop of the a subunit of Na + /K + ATPase on TNP-ATP binding and p -nitrophenylphosphatase activit...

Ngày tải lên: 19/02/2014, 16:20

... to changes in concentration of the more toxic isomer of chiral OPs and reflects the rate of detoxification, rather than degradation, of cyclosarin, IMP-pNP and soman. In the case of symmetric OPs such ... of PON1 [18]. However, Yeung et al. [17] have shown that the paraoxonase activity of H115W PON1 is even higher than that of the wild- Fig. 9. Time-course of IMP-pNP degrad...

Ngày tải lên: 16/03/2014, 13:20

... Antibacterial activity of LK peptides (Eur. J. Biochem. 270) 2 217 The antibiotic activity of cationic linear amphipathic peptides: lessons from the action of leucine/lysine copolymers on bacteria of the ... [LK15(3.6)] the activity of which was similar to that of melittin, a bee venom peptide known as one of the most efficient natural peptides in killing bacteria [8,39–41...

Ngày tải lên: 23/03/2014, 17:21

... Laboratory of Ionic Channels of Cell Membranes, Institute of Cytology of RAS, St Petersburg, Russia 2 Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute of RAS, ... presence of liposomes composed of anionic lipids [35]. The forma- tion of an ion-conducting channel probably proceeds through the association of several BASP1 monomers on the s...

Ngày tải lên: 28/03/2014, 23:20

... enzymatic activity of the nuclear matrix- localized SRPK1 is repressed. These results suggest a new role for SAFB proteins as regulators of SRPK activity and underline the importance of the assembly of ... significance of enzyme–substrate contacts for catalysis. This study highlights the importance of the interaction of a phosphoserine of the RS domain of the substrate wi...

Ngày tải lên: 30/03/2014, 01:20

... Photon Source, Argon- ne National Laboratory. Use of the Advanced Photon Source was supported by the U. S. Department of Energy, Of ce of Science, Of ce of Basic Energy Sci- ences, under Contract No. ... black. (C) Stereoview of the alignment of the active sites of AfRio1 (green) and AfRio2 (orange; PDB code 1ZAO). (D) Stereoview of the alignment of the active sites and bo...

Ngày tải lên: 30/03/2014, 20:20