... small intracellular protein capable of chelating severalmetal ions, including copper. It contains many cysteineresidues, which allow binding and storage of copper. Fur-thermore, MT1A is inducible, ... trafficking in hepatocytes. Copper uptake is mediated by the receptor CTR1. In the cell, copper can bind to copper chaperones such as CCS, COX17, and ATOX1 which in turn deploy to SOD1, the mitochondrial ... differentially expressed genes within atarget panel, investigating different groups ranging from copper-associated subclinical hepatitis (CASH) to a clinical chronic hepatitis with high hepatic copper concentrations...