báo cáo khoa học:" Rasch analysis of the Hospital Anxiety and Depression Scale (HADS) for use in motor neurone disease" pot

... 8 of 8 range of the scale caused by removing the effects of local dependency in the data through the testlet design. The performance of the HADS has been called into question following Rasch analysis ... understanding of the measurement properties of the HADS in MND. The results of our study indicate that the standard 7- item measure of depressio...

Ngày tải lên: 12/08/2014, 00:20

... helpless- ness and somatic symptoms of anxiety and depression. The convergent validity of the HADS should be confirmed in relation to the other anxiety and depression scales. Joint factor analysis ... the affective and cognitive aspects of anxiety and depression. The HADS consists of 14 items; the anxiety (HADS-A) and depression (HADS-D) subsc...

Ngày tải lên: 18/06/2014, 18:20

... decline of step I, and to retard the rise to F m . With dPQ, the J step was lowered and the subsequent rise was retarded. Kinetic information on each phase can be of great help in investigating the ... fraction of the PSII cen- ters are inhibited for Q B reduction by binding of a DCMU molecule in the Q B pocket; the remaining PSII centers are unaffected. Howeve...

Ngày tải lên: 19/02/2014, 05:20

... estern blot analysis (Fig. 5 ). These r esults indicate that the bHLH region, including His57 and Arg65, is responsible for t he E-box binding. Determination of the region in BMAL1 for binding to ... 2004 whereas the N-terminal region, containing the bHLH domain, is not essential for the interaction. Dominant-negative DEC1 counteracts the suppression of CLOCK/BMAL1...

Ngày tải lên: 19/02/2014, 16:20

... certain Trp residues in the C-terminus of HpPex5p to the dansyl cap in the PTS1 peptides, the distance between the dansyl cap in L2 and the three tryptophan residues in the model were measured. The values ... structure of the N-terminal domain of the human homologue, solved at 2.2 A ˚ resolution [11]. The obtained model covers residues 254–568 of HpPex5...

Ngày tải lên: 21/02/2014, 00:20

... structures determine the unique functions of these flavin proteins? In this study, we present the crystal structure of DvMF flavoredoxin and discuss the key residues for ligand binding and metal ion binding, ... 3D). Redox potential of recombinant flavoredoxin Figure 4 shows the results of linear regression analysis of the logarithms for the redox ratio of th...

Ngày tải lên: 07/03/2014, 02:20

... (two cDNAs). Initial mapping of the region of PP2Ac involved in TIPRL binding was obtained from the cDNAs that showed positive interaction with TIPRL. The extension of these cDNAs is shown in Fig. ... recombi- nant proteins. The 3D arrangement of the binding sites for TIPRL and a4 on the surface of PP2Ac shows that they are in close proximity, but not overlappi...

Ngày tải lên: 07/03/2014, 05:20

... lectin complex (RCSB Protein Data Bank code 1X1V) [39] was calculated using the forcefield of discover3 and used to anchor the pyranose ring of the sugars into the binding sites of the lectin. The ... keeping constrained the amino acid residues forming the carbohydrate-binding site. The program tur- bofrodo was used to draw the Ramachandran plots [45] and perform...

Ngày tải lên: 14/03/2014, 23:20

... initiate a bioinformatic anal- ysis of plant b-glucosidases to obtain insights into the evolution of the molecular sites involved in the two modes of aglycone binding. The amino acid sequence of Zm-p60.1 ... aglycones in Zm-p60.1. Interest- ingly, both lysine residues and the leucine residue are conserved in all five enzymes of the group, and the alanine resid...

Ngày tải lên: 16/03/2014, 04:20

... A milestone in the study of peptide s ynthetases was the determination of the A-domain structure of GrsA Phe -A [8]. Aspects of speci®city and binding were superimposed on other A-domains and with the ... This hypothesis was supported by the ®nding that a single mutation of the Fig. 1. Genes and domain organizations of gramicidin S and tyrocidine A synthetase...

Ngày tải lên: 17/03/2014, 11:20