... advantage of p53 mutation analysis, and a unique feature of this database, is the availabil-ity of the residual activity of the majority of p53 mis-sense mutants. The biological activity of mutant ... of a severe mutant. At the otherend of the spectrum, where we have low energy, thereis 75% probability for the mutation to be nonsevere if the energy is 0.125 or lower. Thus, on the basis of ... divider of the data. The algorithm was alsoevaluated with other separation limits between the classes (1%, 2%, 3%, 5%, 10%, 15%, 20%, 30% and 40% activity) but, in all of these cases except for the 1%...