báo cáo khoa học: " Assessing and improving needle exchange programs: gaps and problems in the literature" pptx

... Access Review Assessing and improving needle exchange programs: gaps and problems in the literature Kate Ksobiech* Address: Center for AIDS Intervention Research (CAIR), Department of Psychiatry and Behavioral ... to conceptually and theoretically organize the variables: needle sharing, needle sharing-extended (includes variations on the basic needle sharin...

Ngày tải lên: 11/08/2014, 20:20

... picture of the exchange process, and (b) utilize the process itself to inter- vene indirectly in the lives of other IDUs. Additional demographic information While collecting and analyzing return ... effectiveness. The logic is simple: the higher the return rate, the less time dirty needles are in circulation, the greater the likelihood that IDUs are using clean nee...

Ngày tải lên: 11/08/2014, 20:20

... Ca 2+ . Removing the proposed Ca 2+ -coordinating residues in positions 1 and 3 of the EF-hand motif significantly compromised the metal-binding capability of the engi- neered protein, indicating that the ... the initial mixture. The fluorescence intensity was normalized by subtracting the contribution of the baseline slope using logarithmic fitting. The Tb 3+ -binding af...

Ngày tải lên: 07/03/2014, 00:20

... deciphering the origin of the destabilization and hence, diminution of the melting temperature (T m ) in the former. Base stacking in the vicinity of A C mismatch in PNAÆDNA and DNA duplexes Intra ... to interrupted stacking, fluctuating nature of the hydro- gen bond and water organization in the vicinity of the mismatch might be the contributing factors for th...

Ngày tải lên: 07/03/2014, 21:20

... peptides, and a B-chain, C-peptide and A-chain, and contains the RXXXRXXI motif in the B chain (B12–B19 in human) for binding to the relaxin recep- tor [3]. Similar to insulin, a mature two-chain peptide is ... [5]. In the present minireview, the expression of relaxin-3 in the brain, and particularly its functions, including the stress response and food intake,...

Ngày tải lên: 29/03/2014, 21:20

... to continue receiving on-going care from their PCPs. They received a folder at the conclusion of the baseline visit including handouts from the American Heart Association containing basic information ... eligible and willing participant was instructed to take the enve- lope in the very front of the appropriate container, open the envelope in the presence of the case ma...

Ngày tải lên: 11/08/2014, 05:22

... activity in the fraction I and II. Synthetic primer-independent DNA polymerization occurs by internal primase and DNA polymerase activities (see the Materials and methods section). The reactions in the ... for p140 and p48 The truncated cDNA corresponding to amino acid residues from 299 to 718 of p140 was cloned into the expression vector pET21a (Novagen) in the Nd...

Ngày tải lên: 20/02/2014, 11:20

... N-tail (Fig. 2). The initial delay increases with the number of Arg residues in the N-tail. The kinetics of modification of the G1 site in Cig30(wt)-P2 and Cig30(4R)-P2 are indistinguishable from the corresponding ... 3). The delayed translocation of the N-tail in Cig30(4R)-P2 and Cig30(1–100)(4R)-P2 suggests that the N-tail ⁄ TM1 region in these constructs has an...

Ngày tải lên: 07/03/2014, 16:20

... PtdIns(5)P, PtdIns(3,4)P 2 and PtdIns(3,5)P 2 with the strongest binding to PtdIns(5)P (Fig. 1). The ORD domain showed a very similar lipid binding pattern as the full- length protein. While the ... for lipid binding and a putative coiled-coil motif for pro- tein–protein interaction. In this study, Osh6p was demonstrated to bind a pool of phosphatidylinositol phosphates (PtdInsP...

Ngày tải lên: 07/03/2014, 21:20

... appears to indicate that there is specific recognition of the orientation of the P-O-C-P linkage in the a,b active site. Taken together, the results of cleavage of compounds 3 and 5 show that the asymmetrically ... asymmetrically acting Ap 4 A hydro- lases can reach the scissile bond either by extending the frame’, as in the case of compound 3,orby shortening the count,...

Ngày tải lên: 16/03/2014, 04:20