báo cáo khoa học: " Medicines and vaccines for the world''''''''s poorest: Is there any prospect for public-private cooperation?" ppt

... of 8 (page number not for citation purposes) Globalization and Health Open Access Review Medicines and vaccines for the world's poorest: Is there any prospect for public-private cooperation? Richard ... margin for the Fortune 500 drug firms has consistently exceeded the margin for all Fortune 500 companies taken together. It is possible that the hi...

Ngày tải lên: 11/08/2014, 18:20

... protein stability is variable, depending on their structural characteristic and their location on the surface [34]. ANS binding To investigate further the description of the mechanism of the pressure ... E202 is lower down in the gorge next to the active serine; (c) E450 is  9A ˚ away; and (d) D74 is located at the entrance of the active site gorge (Fig. 1). D74 (...

Ngày tải lên: 08/03/2014, 10:20

... nine random amino acids, followed by a His6-tag in the C-terminus of capsid protein 10. Thereby, the phages display a random nonamer on their surface, and by interactions of the His6-tag the phages ... Asp and Glu are roughly equally distributed in this position in the wild- type HC and the three HC mutants. Therefore, Arg143 and Lys192 do not distinguish between Asp or Gl...

Ngày tải lên: 22/03/2014, 21:21

... site exists in the C-terminal domain of HSP90. The aim of the present study is to elucidate the regions within the C-terminal domain responsible for the bindings to the middle domain and to a ... present, it is ambiguous whether this discrepancy is caused by the variation in the binding sites of HSP90 for the respective substrates or if the respective regions...

Ngày tải lên: 23/03/2014, 20:22

... that the contact area between the tip and the adhesive was less than 78.5 nm 2 , the elasticity of the Sundew adhesive is quite large. Since the maximum ver- tical withdraw distance setting for the ... cells/ mm 2 for the negative control, 1681 cells/mm 2 for the positive control, and 1253 cells/mm 2 for the Sundew adhesive coated surface. Due to the non-un...

Ngày tải lên: 11/08/2014, 00:22

... detectable band pat- terns. These high-molecular-weight bands were not detected in the protein samples examined for multiple other, different, nonanther tissues (Figure 8B). The basis for this difference ... performed the Solexa mRNA transcription profiles for ZmSUN1-5 and GAPDH . SPM and HWB and CRS interpreted the results, and SPM and HWB wrote the manuscript. All...

Ngày tải lên: 11/08/2014, 11:21

... Over the rel- atively short period of the last 5 to 8 years, many new players have emerged on the global scene with additional funding and their own sets of priorities for investing in health and ... United Nations players like the WHO, World Bank and UNICEF have changed their focus. We will stimulate discussion about how best to enhance the prospects of improving health at...

Ngày tải lên: 11/08/2014, 18:20

... 34% for MDM2, 71% for NOXA and 61% for p53R2, and around 45% for the other four promot- ers. For some specific mutants, the differences in activity are very large (Table 10). These mutants are therefore expected ... use these residues for binding or that they are not necessary for binding as the DNA binds sufficiently hard to the other DNA binding residues. For the...

Ngày tải lên: 18/02/2014, 11:20

... Thus, the apoptotic volume decrease may further disarrange the balance between survival and death signals, thereby promoting execu- tion of the apoptotic program. Concluding remarks It is well ... stimulate a rapid osmolyte uptake that is important for mitogenesis [16]. For example, a rapid and transient Na + and amino acid influx is essential for the mitogenic respon...

Ngày tải lên: 18/02/2014, 16:20

... which the candidate fact is extracted; and c) the pattern- based scores of the candidate fact. The latter fea- ture converts the scores of the patterns extracting the candidate fact into a score for ... facts. This is the case for the first five candidate facts in Figure 3. For ex- ample, the first word Richard from one of the can- didate facts is similar to...

Ngày tải lên: 20/02/2014, 12:20