báo cáo khoa học: " Better retention of Malaysian opiate dependents treated with high dose methadone in methadone maintenance therapy" potx

... 7:30 http://www.harmreductionjournal.com/content/7/1/30 Page 8 of 8 RESEARC H Open Access Better retention of Malaysian opiate dependents treated with high dose methadone in methadone maintenance therapy Nasir Mohamad 1,2*† , ... other independent studies also showed that high doses of methadone were significantly more effec- tive in suppressing illicit h...

Ngày tải lên: 11/08/2014, 18:20

... interacting pro- teins. Seven such motifs are present in the proline-rich domain of the longest isoform of tau in the human central nervous system (CNS). Two distinct PXXP motifs in tau, residing within ... tyrosines present on tau [17–19], and tau also interacts with Fyn via its Src homology (SH)3 domain [20,21]. The SH3 domain of Fyn binds to proline-rich motifs within the seq...

Ngày tải lên: 14/02/2014, 14:20

... using crotonyl-CoA as a substrate [15]. The gene encoding this bifunctional protein was named AUH (‘AU bind- ing homolog of enoyl-CoA hydratase’). The RNA- binding activity of the human protein ... exists [8]. Interestingly, certain patients with Smith–Lemli–Opitz syndrome also show abnormally increased plasma levels of this compound, further challenging our under- standing of 3-met...

Ngày tải lên: 19/02/2014, 07:20

... examining a protein – DNA interaction. In this method the protein-dependent association of two fluores- cent-labelled DNA fragments each containing about half of a sequence defining a protein-binding ... also inhibits albumin uptake by astrocytes. Moreover, megalin colocalizes with caveolin-2 in the presence of albumin and the silencing of caveolin-2 expression reduces albu- min u...

Ngày tải lên: 19/02/2014, 07:20

... the C-terminal region, including the PAS-B domain of BMAL1, is required for the binding to DEC1, Fig. 4. Identification of the domain of D EC1 that interacts with BMAL 1. Interactions of various ... ncubated with a control protein. Fig. 6. Identification of t he domain of B MAL1 that inte racts with DEC1. Interactions of various truncated BMAL1 mutants with DEC1 in NIH3T...

Ngày tải lên: 19/02/2014, 16:20

... changes of the protein part in Mglu. A comparison of the sub- strate-binding pocket of Mglu, which is highly specific for l-glutamine, with that of Erwinia carotovora asparaginase, which has substrates ... 422 and 428 aa; nine aa in total) were located near the interface of the physiological dimer. The C- terminal domain may contain structural features involved in protein–pro...

Ngày tải lên: 06/03/2014, 09:22

... counterparts, in agreement with the higher mass of BChE subunits [37]. This indicates a predominant in uence of the catalytic domain on oligomerization. Role of the C-terminal cysteine Mutation of the ... indicat- ing a predominant in uence of the catalytic domains. However, addition of a cysteine within the aromatic-rich segment of the t peptides modified the oligomeric pa...

Ngày tải lên: 07/03/2014, 03:20

... importance in attaining and maintaining tissue integrity. In the present study we investigate the binding properties of wild-type decorin, two decorin mutants and a truncated decorin species with type ... decorin. (B) Inter- action of type I collagen with t he inner surface of the decorin core protein and type VI c ollagen b inding with its noncollagenous domain to the outer s...

Ngày tải lên: 07/03/2014, 16:20

... staining that colocalized with the Cajal body protein marker p80-coilin in the nucleus of HEK293 cells treated with Adox (Fig. 7Ai–iii). This finding may, in addition, strengthen the hypothesis of the ... the N-terminus and C-terminus of Ki-1 ⁄ 57 were used as ‘baits’. RNA-binding activity of Ki-1 ⁄ 57 in vitro Although Ki-1 ⁄ 57 does not have any classic RNA-bind- ing doma...

Ngày tải lên: 16/03/2014, 02:20

... binding in the presence of saponin [17]. Incubation of untreated cells with saponin did not significantly change the number of binding sites. After stimulation with SST-14, cell surface binding ... and cells were incubated for another 0–120 min. The recov- ery of surface binding sites was determined as described above. Interestingly, during the first 15 min of incuba- tion, surf...

Ngày tải lên: 16/03/2014, 06:20