... designs is due to route of administration(intrauterine versus intraperitoneal), rate of infusion, ratstrain (Sprague-Dawley versus Wistar) or some other fac-tor is not clear. In the present ... However, spontaneous uterine contractionsinduced by LPS in the rat do not appear to be mediated byprostaglandins, as prostaglandin inhibitors fail to dimin-ish this response [36]. This appears contrary ... behind by the catheteriza-tion procedure, thus effectively diminishing the size of the inoculum.It is our hope that publication of the present negativeresults will either spur successful efforts...