... conceived this manuscript, and led the writing and analyses. CVL and MM participated in the conceptualiza- tion and drafting of this manuscript. All authors read and approved the final manuscript. Acknowledgements The ... Access Research article Predicting healthcare employees' participation in an office redesign program: Attitudes, norms and behavioral...
Ngày tải lên: 11/08/2014, 16:21
... All ERBB proteins have four functional domains: an extracellular ligand-binding domain; a transmembrane domain; an intracellular tyrosine kinase domain; and a C-terminal regulatory domain [2]. The ... and ERBB4 (including betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin (NRG) (also known as heregulin) that binds to ERBB3 and ERBB4. NRG1 and NRG2 bind to bo...
Ngày tải lên: 16/02/2014, 09:20
Báo cáo khoa học: Peroxiredoxins as cellular guardians in Sulfolobus solfataricus – characterization of Bcp1, Bcp3 and Bcp4 pot
... damage to the main biomole- cules and membranes and essential metabolic functions [1]; to maintain a low intracellular ROS level, cells are equipped with an array of antioxidant systems, in the first ... Bcp3 and Bcp4 bcp1, bcp3 and bcp4 were amplified by PCR from S. solfataricus genomic DNA and cloned into pET- 30c(+). The genes were expressed in Escherichia coli cells and th...
Ngày tải lên: 07/03/2014, 05:20
Báo cáo khoa học: Inter-flavin electron transfer in cytochrome P450 reductase – effects of solvent and pH identify hidden complexity in mechanism potx
... Accordingly, single traces detected as absorbance changes were transformed into changes in extinction coefficient and fitted to a double-exponential equation with a sloping baseline, where the sloping ... nm and analysed as in Fig. 3 yielding fast up-phases (up-tri- angles) and slower down-phases (down-triangles). The ratio of the rate constant k n , obtained at a certain fraction of...
Ngày tải lên: 07/03/2014, 06:20
Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin pot
... where the transmembrane helix branches off in MAO A and B (Fig. 3A). The SWIRM domain is a motif com- monly found in chromatin enzymes and is responsible for protein–protein and DNA–protein interactions [36]. ... activity in the chromatin context Genes coding for LSD1 ⁄ K-demethylase 1 proteins exist only in eukaryotes and have undergone distinct evolutionary development in...
Ngày tải lên: 16/03/2014, 02:20
Báo cáo khoa học: Yeast oxidative stress response Influences of cytosolic thioredoxin peroxidase I and of the mitochondrial functional state pot
... peroxiredoxin in human breast cancer. Anticancer Res 21, 2085–2090. 57 Shen C & Nathan C (2002) Nonredundant antioxidant defense by multiple two cysteine peroxiredoxins in human prostate cancer ... H 2 O 2 ,0.1lgÆmL )1 antimycin A (anti A), and 2.5 lgÆmL )1 FCCP singly or in association. Proceedings were performed as described in Fig. 1. cTPxI and respiratory function in ant...
Ngày tải lên: 16/03/2014, 14:20
Báo cáo khoa học: Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of b-oxidation doc
... TG in lipid droplets in adipophilin-overexpressing cells is relatively inaccessible to HSL and other lipases. This interpret- ation is in agreement with results obtained in murine adipocytes and ... active and diverse roles in the cellular life cycle. Indeed, lipid droplets are involved in the maintenance of intracellular cholesterol balance in fibroblasts [12] and appear...
Ngày tải lên: 23/03/2014, 10:21
Báo cáo khoa học: "Producing Contextually Appropriate Intonation in an Information-State Based Dialogue System" docx
... framework, built using TrindiKit 2 . GoDIS handles informa- tion exchange dialogue in travel agency and au- 2 http://www.ling.gu.se/projektfirindifirindikit/ toroute domains, and action-oriented ... level of meaning that unifies a range of interacting contextually- dependent aspects of utterance realization, en- countered in various combinations within and across languages. Determi...
Ngày tải lên: 31/03/2014, 20:20
Báo cáo khoa học: "Axillary bud proliferation of 2 North American oak species: Quercus alba and Quercus rubra" ppsx
... rectangular block con- taining the embryonic axis. The tissue block was sterilized for 2 min in a Clorox solution (as above) and rinsed 3 times in sterile water for 5 min ... Latin square designs. Experiment 1 was a preliminary study to investigate if in vitro bud elongation was possible and used the same concentrations of BA and NAA a...
Ngày tải lên: 08/08/2014, 19:21
Báo cáo khoa học: "Breast cancer risk factors in Turkish women – a University Hospital based nested case control study" pps
... activity, and anovulation in overweight and obesity [46-51]. Conclusion Our findings suggest that age and induced abortion were found to be significantly associated with increased breast cancer risk ... helped to draft the manuscript and acquisition of data, analysis and interpretation of data, she has been involved in drafting the manuscript or revis- ing critically for importa...
Ngày tải lên: 09/08/2014, 04:21