báo cáo khoa học: " Indian vaccine innovation: the case of Shantha Biotechnics" pptx

... success. The late C.K. Prahalad identified the existen ce of a significant market among the lower-income populations of the world - the so- called “bottom of the pyramid” [44,45]. While the mar- ket ... on innovation the industry risks falling into the trap of focusing on low risk and profitable drugs rather than important health challenges. As of early 2008, of...

Ngày tải lên: 11/08/2014, 14:21

... one engages with theory at the start of the evaluation process through the development of conjectured CMO threads; they are the theories of change that one tests and refines throughout the evaluation ... and theoretical integrity. The first stage of the synthesis involved the identifica- tion of concepts, programme theories, and subsequent framework development (Figu...

Ngày tải lên: 10/08/2014, 10:22

... confirmed the active role of miR-23a in the growth promotion of malignant cells. The fundamental function of miRNAs is to regulate their targets by direct cleavage of mRNA or by inhibi- tion of protein ... with the first potential binding site of the IL6R mRNA 3¢ UTR. (A) The three EGFP reporter vectors bear- ing mutations of the miR-23a seed region binding site are...

Ngày tải lên: 18/02/2014, 04:20

... observations, the rate of cofilin binding to F-actin in the presence of 2–30 mm Pi is the same at pH 6.5 and 8.0. The influ- ence of Pi on the relative rates of cofilin binding at these two pH values ... dependence of the Pi inhibition of cofilin binding may contribute to the pH regulation of the actin depolymerizing activity of cofilin, which is important in view...

Ngày tải lên: 19/02/2014, 07:20

... may enter the citric acid cycle completing the catabolism of the pyrrolidine moiety of nicotine. Expression of the genes of these enzymes was dependent on the presence of nicotine in the growth ... expression of these genes depends on the presence of nicotine in the growth medium and we have determined the enzyme activities of the proteins. Our results demo...

Ngày tải lên: 19/02/2014, 07:20

... antibodies to the subunits of the yeast bc 1 complex indicated on the left side of the blots. 1212 V. Zara et al. (Eur. J. Biochem. 271) Ó FEBS 2004 Further insights into the assembly of the yeast ... relatively unaffected. Therefore, the absence of subunit 6 appeared to alter the rates of processing of two of the redox subunits and caused minor changes in amou...

Ngày tải lên: 19/02/2014, 12:20

... with the familiar pattern of expression of the principally embryonic cA–F genes in the rodent lens [41,47]. The absence of expression in outer layers of the lens contrasts with the expression of ... encodes the first two structural motifs, and hence the N-ter- minal domain of the protein, just as in the genes for cS and cA–F. However, the second half of the...

Ngày tải lên: 19/02/2014, 17:20

... decrease as we increase the length of the se- quence. Therefore the variation of the branching en- tropy (VBE) should be negative. When we observe that it is not the case, Harris hypothesizes that we are ... the string by substracting the mean of the VBEs of the strings of the same length. Writing ˜ δh → (x) and ˜ δh ← (x). The normalized VBEs for the string...

Ngày tải lên: 19/02/2014, 19:20

... the question arises concerning the mechanisms underlying the orchestrated expression of these enzymes by the oxygen tension. The findings that the effect of hypoxia on the gene expression of the ... hydroxylases. With the exception of PDI, which is known to be induced by the UPR [41], however, none of the other enzymes was relevantly induced by the UPR, suppor...

Ngày tải lên: 20/02/2014, 02:21

... or maturation of the protein. An increase was also observed in the rate of degradation of the remaining mutant protein (20% left of the protein) vs. the wild type (40% left of the protein) at 3 h of chase (Fig. ... activation of Ga 16 and Ga q subunits. Therefore the lack of change in the rate of degradation cannot be due to lack of receptor-activa- tion o...

Ngày tải lên: 20/02/2014, 03:20