báo cáo khoa học: " Gene expression and hypoxia in breast cancer" doc

... function, contributes to an increase in free radical generation in hypoxia, increases cell survival under hypoxia, induces a switch to glycolysis in both normoxia and hypoxia, and upregulates the ... prognosis in endometrial, colorectal, head and neck and non-small- cell lung cancer [22-26], and the expression of this gene in breast cancer has been linked to HI...

Ngày tải lên: 11/08/2014, 12:21

... be key in finding novel treatments. Methods: Using five independent molecular and clinical data sets with a set of computational algorithms we were able to identify a gene- gene and gene- microRNA ... range in the activity levels between groups, and the distinct difference between them.(B) P38 signaling network, the genes highlighted in blue are the genes in the P38 signali...

Ngày tải lên: 11/08/2014, 12:21

... priority union in ALE with the example in (15): Source is the de- fault input, and Target is the strict input. The hierarchy we assume is the same as shown in (3) and (4). Information about ... ellipsis. In the general spirit of Priist's analysis, however, we have taken one step further down the line towards determi- ning parallelism by postulating that calculating...

Ngày tải lên: 08/03/2014, 07:20

... could be combined and coordinated too. Complex coordinations involving ellipsis and gapping are much more challenging. In multiple-distinct coordination, each conjoined clause is generated, ... complexity into the coordination pro- cess. One major task of generating coordina- tion expression is identifying identical elements in the propositions being combined. In Func- 1221...

Ngày tải lên: 31/03/2014, 04:20

... of factors including molecular studies and preclinical models in order to study disease mechanism and potential targeted therapy: the kind of clinical infor- mation that could be gained through ... an interesting clinical response to sildenafil in Waldenström's mac- roglobulinemia [10]. It is without question that case reports do not replace well designed randomized clinical tria...

Ngày tải lên: 11/08/2014, 10:23

... progression, the inheritance and expression of mutant huntingtin is the primary cause of HD. Examination o f t he regulation of individual m utant huntingtin-affected genes such as CB1 may increase our understanding ... repeat a nd relative expression of the gene encoding mutant huntingtin (HD). Although it is known that the coding region of CB1 is contained within a single exon in...

Ngày tải lên: 16/03/2014, 18:20

... of profi- brotic chemokines and cytokines and cause skin an d pulmonary fibrosis in animal models and in the clinic [12-14]. On thi s basis, the potential of using bleomycin * Correspondence: clare.isacke@icr.ac.uk; ... TGF-beta1 and bleomycin intracellular signaling through autocrine regulation of Smad 3 binding to the proximal promoter of the Smad 7 gene. J Cell Biochem 2006, 9...

Ngày tải lên: 09/08/2014, 09:20

... differences in the expression profiling platforms. In this study we have investigated the heterosis and gene expression profiles for a set of maize hybrids with varying levels of parental genetic ... transcriptional variation observed in more genetically distant inbreds. Indeed, the intergenic space in the maize genome is known to be highly polymorphic among inbred lines [12,2...

Ngày tải lên: 12/08/2014, 05:20

... pancreatic juice and intestine: inadequate for role in zinc absorption. Am J Clin Nutr 35, 1–9. 16 Evans GW & Johnson PE (1980) Characterization and quantitation of a zinc binding ligand in human ... 829 hydrophobic index of the residues within the window centered on amino acids involved in metal binding, it can be noticed that regions around His6 and His8 in the human prote...

Ngày tải lên: 19/02/2014, 02:20

... specifically inhibit store-operated calcium channels and may thereby reduce the serotonin- induced sustained increase in [Ca 2+ ] i , as has been shown for endothelin-1-induced Ca 2+ increase in Rat1 cells ... the deletion of amino acids 1–225, including the Ca 2+ ⁄ calmodulin-binding IQ domain, from Ras-GRF1 reduced both basal and serotonin-stimulated ERK1 ⁄ 2 phosphorylation. Further...

Ngày tải lên: 19/02/2014, 18:20