báo cáo khoa học: " Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer’s disease" doc

... http://genomemedicine.com/content/2/11/83 doi:10.1186/gm204 Cite this article as: Orešič M, et al.: Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer’s ... avenues. Bioinformatics tools enabling a systems medicine approach to AD Many tools are available for mining of heterogeneous biological data, although the...

Ngày tải lên: 11/08/2014, 12:21

... University of Ireland, Maynooth, Co. Kildare, Ireland. 52 Department of Systems Biology and Bioinformatics, University of Rostock, 18051 Rostock, Germany. 53 Faculty of Medicine, University of Maastricht, ... clinical and patient-reported disease markers. It uses the power of computational and mathematical modeling to enable understanding of the mechanisms, pro...

Ngày tải lên: 11/08/2014, 12:21

... nuclear pre-mRNA and to catalyze the accurate removal of introns and ligation of exons to yield a mature mRNA. The affinity of the splicing complexes to RNA was used in this approach for the isolation of the ... from the sequence. However, this stretch of consecutive sequence is ÔlockedÕ within the peptide by the masses of the fragments that define the begi...

Ngày tải lên: 31/03/2014, 07:20

... dissociation of these two proteins inhibits the antiapoptotic activity of Bcl-2 by initiating the release of cytochrome c from mitochon- dria into the cytosol and increasing the activities of caspase 3 and ... mediates the interaction with Bcl-2 and other close Bcl-2 homologs, such as Bcl-xL and Mcl-1 [45]. Mutation of the BH3 domain of Beclin 1 or of the B...

Ngày tải lên: 28/03/2014, 23:20

... respective implication of both partners in the phenomenon. In the zooxanthella, heat stress has been demonstrated to reduce the photosynthetic rate by decreasing the effi- ciency of the photosystem II [4–6] and ... degeneration [8,9,53,56] and ⁄ or gastrodermal detachment [7,52,57]. Nevertheless, independently of the resulting effect of the thermal stress, all mechani...

Ngày tải lên: 30/03/2014, 10:20

... identify the lymph vessels and lymph nodes. The breakdown of the identification by CTLG showed clear enhancing of the lymph nodes in 88% of the patients, while in 5% of the patients identification of ... identification rates by CTLG and the dye-guided method Identification of the SN(s) was achieved in 212 (96%) of the total 221 performances of CTLG. The...

Ngày tải lên: 09/08/2014, 07:21

... each other). The value (the sign) of a cycle is the product of the values (the signs) of its steps. The sign o f the magnitude of a Ôminus combined autoinfluence path of order pÕ equal those of the ... contain parallel and antiparallel arrows). The sign of that element therefore depends on the both the sign and the magnitudes of these influen ce paths (...

Ngày tải lên: 19/02/2014, 16:20

... measures the similarity of the contexts of the occurrences of the word in terms of the prox- imal words. 3.3 Similarity based on Proximity to NE Categories Here, for each word (w i ) in the corpus ... using the important words for previous two and next two positions along with the suffix, prefix, digit and POS information. 5.3 Relative Effectiveness of Clusteri...

Ngày tải lên: 08/03/2014, 01:20

... i, k is the kth word in sentence i, tf jk is the frequency of word k in document j, n d is the number of documents in the reference corpus, and df k is the number of documents in the reference ... and Experiment 2 for any of the 15 texts (all Fs < 1). Therefore, in order to lend more power to our statistical tests, we collapsed the data for each tex...

Ngày tải lên: 17/03/2014, 06:20

... described above for 1D gels. After blotting of the two-dimensional gels (before blocking of the membrane and application of the antibody), the membranes were stained with Ponceau Red and scanned. 4860 ... (PDT). The mode of cell death by PDT may be either apoptosis or necrosis, depending on the nature and concentration of the photosensitizer and the amount...

Ngày tải lên: 23/03/2014, 15:21