clinical and neuropsychological features of alzheimer s disease

... Psychiatric Press, 2000 66 Morris JC, Mohs RC, Rogers H, et al Consortium to establish a registry for Alzheimer s disease (CERAD) clinical and neuropsychological assessment of Alzheimer s disease ... DeKosky S Early intervention is key to successful management of Alzheimer disease Alzheimer Dis Assoc Disord 2003;17(Suppl 4) :S9 9–104 19 Leifer BP Early diagnosis of Alzheimer s disease: clinical ... deficits are prominent and become more severe and global as AD progresses Behavioral and personality changes, including agitation, aggression, and psychosis, often emerge as the disease progresses...

Ngày tải lên: 05/03/2014, 23:20

... Alzheimer s disease and dementia will find this book of interest, including physicians, medical students, psychologists, scientists, graduate students, and allied health professionals including nurses, social ... acetylcholinesterase inhibitors, the first class of drugs approved by the FDA for treating Alzheimer s disease In 1984, the first clinical criteria for the diagnosis of Alzheimer s disease was published, and ... ceroid lipofuscinosis Multiple infarct dementia “Binswanger s disease “Small vessel ischemic disease CADASIL Schizophrenia Dementia syndrome of depression Bipolar disorder Malingering Obsessive...

Ngày tải lên: 14/03/2014, 21:20

... memory loss in a mouse transgenic model of Alzheimer' s disease J Neurosci 2002, 22:6331-6335 Selkoe DJ, Schenk D: Alzheimer' s disease: molecular understanding predicts amyloid-based therapeutics Annu ... of the numbers of Aβ-positive objects (or the sum of the areas of the Aβ positive objects) for the entire section and dividing by the sum of the areas of all ROIs This analysis was performed blinded ... performed image analysis, data analysis and manuscript preparation; IH performed immunohistochemistry, image analysis, data analysis and presentation and assisted with perfusions and animal care;...

Ngày tải lên: 19/06/2014, 22:20

... majority of AD researchers assume Risk Factors for Disease Progression in Alzheimer' s Disease a linear slope, but some investigators also suggest trilinear models of decline or even more trajectories ... longitudinal assessment of gene dysregulation at different disease stages This could assist in making diagnoses, tracking the disease course and evaluation of disease altering interventions Blood derived ... proposed the use of a scale, consisting of the educational level, insight assessment, the presence of psychosis, the activities of daily living as well as MMSE Measured at baseline this scale might...

Ngày tải lên: 28/06/2014, 05:20

... Alzheimer sdisease patients and being as basisfor more extensive studies The results of this thesis gave new contributions for studies in the elderly especially on dementia and Alzheimer s diseaseand ... of Alzheimer s disease patients and related factors 4.1.1.1 Socio-demographiccharacteristics of Alzheimer s disease patients Age and gender of Alzheimer s disease patients In our study.Patients ... review in Alzheimer' s disease and in other countries 4.1.1.3 Quality of life of people with Alzheimer' s disease Assessing the quality of life in Alzheimer' s disease (QOL-AD) Our research shows that...

Ngày tải lên: 25/07/2014, 11:36

... cognitive assessments The adoption of a systems approach to study AD will demand integration of heterogeneous data (such as molecular and image data) and studies of disease- associated molecules and ... Lovestone S: Alzheimer s disease- do tauists and baptists finally shake hands? Trends Neurosci 2002, 25:22-26 14 Mattsson N, Zetterberg H, Hansson O, Andreasen N, Parnetti L, Jonsson M, Herukka SK, ... mechanism for Alzheimer s Disease and Down syndrome Proc Natl Acad Sci USA 2010, 107:6538-6543 40 Brites P, Waterham HR, Wanders RJA: Functions and biosynthesis of plasmalo­ ens in health and disease...

Ngày tải lên: 11/08/2014, 12:21

... development is the result of an aberrant shift in activity of tau kinases and phosphatases [3] Thus, although targeting plaques and NFTs may ameliorate some of the consequences of AD and no doubt lessen ... causes decreased activity of critical enzymes because activity of the enzymes is dependent on optimal metal loading Cu deficiency is central to the recessive Menkes and Wilson diseases, and has ... is increased in cerebrospinal fluid in Alzheimer s disease but not Parkinson s disease Alzheimer Dis Assoc Disord 8, 190–197 Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper...

Ngày tải lên: 07/03/2014, 10:20

... localization of these isoforms in the brain In order to try to understand how these isoforms may differ, we examined the expression of the isoforms known to be transcribed in brain tissue, isoforms RCAN1-1 ... antisense and sense (control) transcript for use as a radiolabeled probe (Fig 4A) Our antisense probe hybridized to tissue sample, as shown by clusters of black grains, whereas our control, sense, ... the Alzheimer s Disease Research Center at the University of Southern California s Keck School of Medicine, Los Angeles, CA Brain tissues, with a postmortem interval of less than h, were fresh...

Ngày tải lên: 16/03/2014, 11:20

... caspases The striking similarity between the substrates for caspases and calpains raises the possibility that both protease families contribute to structural dysregulation and functional loss of ... proteolysis results from caspase and calpain activation This work confirms the cross-talk between caspase and calpain and identifies a novel mechanism associated with the proteolysis of several MAPs and ... variety of injuries and diseases of the central nervous system Thus, identification of mechanisms that involve calpains and either promote or prevent cell apoptosis provides new approaches for treating...

Ngày tải lên: 23/03/2014, 10:21

... over-expression of HMGB1 in GC is reported to be associated with tumor invasiveness and metastasis [1517] In almost all of these studies, the over-expression of HMGB1 has been documented in tissues by ... data support and analysis and pvalues < 0.05 were considered as statistically significant differences Results Characteristics of the subjects The 227 subjects studied included 50 patients with ... inflammatory disease They were also excluded if they had a history of chronic illness such as: autoimmune disease, rheumatic disease, chronic infection or inflammatory disease, or other cancers Subjects...

Ngày tải lên: 18/06/2014, 15:20

... numerous reports of increased levels of cytokines in the brains of Alzheimer' s disease patients, and in transgenic mouse models of Alzheimer' s disease [10-12] However, all these reports have focused ... drugs on risk of Alzheimer' s disease: systematic review and meta-analysis of observational studies BMJ 2003, 327:128 Szekely CA, Thorne JE, Zandi PP, Ek M, Messias E, Breitner JC, Goodman SN: ... expressed in picograms per milligram of protein P < 0.05 was considered statistically significant Table 1: Quantification of Aβ levels in TgAPPsw and PS1/APPsw mouse brain slices Data expressed as...

Ngày tải lên: 19/06/2014, 22:20

... members where possible The study was approved by the Board of Medicolegal Affairs of Finland Senile plaques and neurofibrillary tangles SP and NFT assessments were made as previously described ... Presence No 280 (57.9%) Yes 204 (42.1%) - statistical mean Statistics Statistical analyses were performed with an SPSS program (version 14.0) Analyses for CRP SNPs and haplotypes used the most ... drugs; SNPs: single nucleotide polymorphisms; SP: senile plaques; TASTY: Tampere autopsy study; TMAs: tissue microarrays Acknowledgements Many thanks to Heini Huhtala and Ilkka Seppälä (for assistance...

Ngày tải lên: 19/06/2014, 22:20

... 1c) Cross-sectioning of the nodule showed that it consisted of various cystic compartments (Figure 2a) The surgical specimen was sent for histopathologic analysis, which showed the presence of multiple ... technical details This finding is in contrast to the results of Greer and Johnson [3] and Gurol et al [9], who observed staining of these cells with PAS Greer and Johnson [3] reported a similarity ... keratocystic odontogenic tumors, but that the former shows less aggressive behavior According to Ramer and Valuri [4], BOC is not an aggressive lesion, and recurrences are the result of conservative...

Ngày tải lên: 11/08/2014, 03:21

... 1c) Cross-sectioning of the nodule showed that it consisted of various cystic compartments (Figure 2a) The surgical specimen was sent for histopathologic analysis, which showed the presence of multiple ... technical details This finding is in contrast to the results of Greer and Johnson [3] and Gurol et al [9], who observed staining of these cells with PAS Greer and Johnson [3] reported a similarity ... keratocystic odontogenic tumors, but that the former shows less aggressive behavior According to Ramer and Valuri [4], BOC is not an aggressive lesion, and recurrences are the result of conservative...

Ngày tải lên: 11/08/2014, 07:20

... more likely Scalding was the most frequent cause of burns in this study This is in line with some reports from other countries that describe high rates of scald burns in children of this age range ... patients (p > 0.05) Frequent cases of burns were observed during the summer, when tandir burns are quite common Table shows the monthly frequency of summer burns The most common causes of burns in ... package (SPSS, Chicago, IL) All data were presented as means (±) standard deviations (S. D.) Parametric tests were performed for data analysis A one-way ANOVA test was performed and post-hoc Page of...

Ngày tải lên: 13/08/2014, 23:20

... annotation of these genes based on their association to human diseases resulted in the identification of 18 disease- related cardiovascular diseases (CVDs), AD/neurodegenerative diseases, stroke and ... elements in disease associated genes Figure Steps taken to analyze Alzheimer' s disease using laser capture microdissected microarray data Steps taken to analyze Alzheimer' s disease using laser capture ... complex diseases Most studies on AD first select a set of differentially expressed genes on which further analysis is performed However, comparing lists of genes from various AD studies is not...

Ngày tải lên: 14/08/2014, 21:20

... microscope operated at 120 V All reagents were supplied by Electron Microscopy Sciences (Hatfield, PA, USA) Assessement of SEC-isolated peptides by HPLC and SDS-PAGE Samples (100 lL) of peptides isolated ... fractions were electrophoresed on 10–20% polyacrylamide Tris-tricine gels (A,C) and 1% agarose gels (B,D), and proteins were visualized by Coomassie stain Lanes HS and LS are molecular mass standards, ... Applied Biosystems Procise 492 cLC sequenator (Applied Biosystems, Framingham, MA, USA) employing standard Edman chemistry, and MS analysis was undertaken using an LCQDECA LC ⁄ MS system (ThermoFinnigan,...

Ngày tải lên: 18/02/2014, 13:20

... neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based on this review all participants ... It has been previously established that APOE variability is not associated with the rate of progression of Alzheimer s disease [51,59,67] The study was designed to address a specific question ... repetition of phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities and Oddities subtest of...

Ngày tải lên: 05/03/2014, 21:20

... OUT OF FOCUS: ALZHEIMER S DISEASE AND RELATED DISORDERS THE COST OF ALZHEIMER S DISEASE As you can imagine, Alzheimer s disease is very expensive The cost of medical care for its victims is only ... As the disease progresses, however, the entire library of memory closes down Memory loss is probably the most common sign associated with Alzheimer s disease In the initial stages of the disease, ... teenagers The second factor to consider is human memory Memory loss—one of the most obvious and distressing symptoms of Alzheimer s disease is much more serious than forgetting the answers on a history...

Ngày tải lên: 05/03/2014, 23:20

... fluorescence We show the application of this assay to the testing of c-secretase inhibitors and PS1 mutants This assay allows for the first time the selection of cell populations and single cells ... DNA constructs into COS-7 and CHO cells resulted in the expression of GFP positive cells Figure 1B shows phase (panels and 3) and fluorescence microscopy (panels and 4) of COS-7 cells transfected ... cleavage of signal peptides by signal peptide peptidases (SPP), an inhibitor of SPP was also tested in our assay Both c-secretase and SPP cleave their substrates within the middle of the transmembrane...

Ngày tải lên: 08/03/2014, 08:20