báo cáo khoa học: " Recent insights into the role of NF-κB in ovarian carcinogenesis" pot

... AB: Recent insights into the role of NF-κB in ovarian carcinogenesis. Genome Medicine 2010, 2:56. Alvero Genome Medicine 2010, 2:56 http://genomemedicine.com/content/2/8/56 Page 3 of 3 in the ... pathway. Abbreviations EOC, epithelial ovarian cancer cells; IKKα, inhibitor of NF-κB kinase α; IKKβ, inhibitor of NF-κB kinase β; IκB, inhibitor of NFκB; IL, in...

Ngày tải lên: 11/08/2014, 12:20

... cytochrome b protein was detectable in the CKL57 strain. We do not know whether the lack of immunoreactivity in the latter strain was due to the inability of the truncated protein to insert into and be ... compared to the wild-type strain. In the case of the VZ9 strain, this was to be expected, based on the reduced growth rate of the single deletion strain...

Ngày tải lên: 19/02/2014, 12:20

... mutation was detected in the six remaining lesions. Several hypotheses may be raised to explain this absence of mutation including the incomplete sensitiv- ity of this type of approach which would ... com- plete loss of any of the three CCM proteins within endothelial cells lining the cavernous capillary cavities. These data were an important step towards the elucidation...

Ngày tải lên: 15/03/2014, 10:20

... family of kinases that are thought to act upstream of the mitogen-activated protein kinas- es (see the accompanying minireview [11] on the bio- chemical interactions of the CCM proteins). Furthering ... phenotype. The myocardium proliferates to a normal number of cells, but instead of building into concentric layers to form the walls of the heart, the myocardial...

Ngày tải lên: 15/03/2014, 10:20

... of binding of E-64 with ervatamin-A and ervatamin-C The modes of binding of E-64 with ervatamin-A and ervatamin-C have been analyzed and compared with the structures of other complexes of the ... family. E-64 binds to these two ervatamins in the same man- ner as that found in other structures of complexes of papain-like cysteine proteases, and here also the bindi...

Ngày tải lên: 18/02/2014, 16:20

... found in the sequences of crotalid factor IX/X-binding proteins; instead, they contained basic residues at these A B Fig. 4. Sequence alignments of RVV-X light chains with other factor IX/X-binding ... glycine/NaOH (pH 9–11). The remaining activity of 5 ng of RVV-X was determined by measuring the clotting time on a coagulation analyser. Biotinylation of RVV-X and far-western...

Ngày tải lên: 07/03/2014, 06:20

... proportional to the amount of rhodamine free in the cytosol. This observation allows the further determination of the concentration of drug free in the cytosol of resistant cells. The determination of k a requires ... k a ÁC i ð3Þ In this work, the rate of P-gp-associated efflux of rhodamine was calculated at the steady-state, taking into account the fol...

Ngày tải lên: 08/03/2014, 08:20

... highlighting the role of b1 integrin in blood vessel morphogenesis. Indeed, conditional deletion of b1 integrin in endothelial cells induces general vascular defects, including reduced branching and ... membrane binding proteins like talin, ezrin, radixin or moesin. FERM domains are composed of three subdomains, F1–F3, arranged in cloverleaf shape. The F3 subdomain has a pho...

Ngày tải lên: 15/03/2014, 10:20

... through the RR domain [49]. Furthermore, an important role of the RR domain in protein-protein inter- action was found for PRR3 when defined as a substrate of the kinase WNK1 [50,51]. In addition, ... primary amino-acid composition of these domains is unlike that of other metal-binding domains, such as an EF-hand [59]. As the primary and secondary structures of the t...

Ngày tải lên: 10/08/2014, 09:20

... than other endothelial cells in the body. In keeping with the theory of endothelial cell activation having a role in ANFH, coagulation-related gene expression in particular serine (or cysteine) ... and therefore predictors of disease initiation or progression are lacking. Two major limitations in the past have impeded the delineation of the pathophysiology: a lack...

Ngày tải lên: 12/08/2014, 14:22