báo cáo khoa học: " High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-κB-complex-dependent gene expression in human heart failure" pps

... in amma- tion. The pro -in ammatory cytokines interleukin-1b, interleukin-6 and tumor necrosis factor- a are able to induce CYP4Fs, whereas the anti -in ammatory cyto- kine interleukin-10 suppresses CYP4F expression ... known as peroxisome prolifer- ator responsive elements in the promoter regions of target genes, thereby inducing gene expression of the target gene. Most...

Ngày tải lên: 22/03/2014, 16:21

... are givenontheleftandtheaminoacidnumbers on the r ight. Letters in the r ight margin des- ignate d omains. The DNA binding domain (C region) is underlined and the ligand binding domain (E region) is u nderlined with dashes. The helix–turn–zipper ... cells for the expression of PIEcR-B1 and PHR3.Therefore,inthe presence of JH II, the increased accumulation of PH R3 mRNA cou...

Ngày tải lên: 23/03/2014, 13:20

... POPF in this study. In contrast, we found that the shape of the upper abdomen significantly correlated with POPF. One of the reasons for the inconsistent results might be the difference in the ... taking particular care to avoid injuring the pancreas. The splenic artery is divided at the end of the pancreatic parenchyma. The splenic vein is ligated and resected a...

Ngày tải lên: 09/08/2014, 07:21

... miRNA genes, located mainly in the intergenic genomic region, by RNA polymerase II [10-12]. There are also a small num- ber of miRNA genes located inside the protein coding genes. For these miRNAs, ... length for a majority of the small RNAs. Combining the deep sequencing and bioinformatics, we discovered 14 novel miRNA families as well as 75 conserved miRNAs in peanuts....

Ngày tải lên: 12/08/2014, 03:21

... conserved functional modules: the DNA-binding domain (DBD) at the amino-terminus and the oligomerization domain in the central region of the protein [1,4]. The HSF DBD belongs to the ‘winged’ helix-turn-helix ... Unlike other winged helix-turn-helix proteins, the wing of the HSF does not appear to contact the DNA. The wing of the Saccharomyces HSF is necessary for...

Ngày tải lên: 18/02/2014, 04:20

... of genes predicted by Zhao based on the spermatozoa SAGE tags [12], whereas no. D was not matched to the gene (Hs. 436980). The reason for this was further investigated, and it was found that the no. ... PCR using only a single primer (the tag-specific primer no. 10). Sequencing could only determine the single primer-prone product. The sequencing results (Table 1) were ana...

Ngày tải lên: 07/03/2014, 04:20

... °CÆmin )1 . The melting point (T m ) was obtained directly from the DSC curve. The enthalpy change (DH cal ) was calculated by the integration of the curve covering area (T m was taken as the ... exists in these mutants (Fig. 1). Thermal analysis of protein unfolding Thermal denaturation determined by DSC was used to measure the stability of the mutant proteins. Based on...

Ngày tải lên: 07/03/2014, 21:20

... example, if the maximum number is 2, then a word can align to 0, 1, or 2 words in the parallel sentence. In other settings, we en- forced a minimum score in the bilingual dictionary for a link to ... words. The similarity score of and is then computed using the following formula: This similarity scoring provides the basis for our newly built dictionary. The algorithm p...

Ngày tải lên: 08/03/2014, 07:20

... °C for 30 min. The reaction was started by injecting 100 lmol of formate into the vial and stopped after 60 min by injecting 1 mL of HCl (1 molÆL )1 ). After another 30 min of incubation, a gas ... mmolÆL )1 NAD + in 0.1 molÆL )1 potassium phos- phate buffer (pH 7.5). The reaction was started by adding FDH and was monitored over 2 min. From the increase in extinction, activity w...

Ngày tải lên: 16/03/2014, 13:20

... immunoprecipitation assays. Mutations of these binding sites abolished not only binding of the Ets protein, but also the intrinsic promoter activity. Increased DNA-binding activity of Ets-1 ⁄ Elk-1 by v-Ha-ras ... in the 5¢ flanking region of the human DPP-III gene in different cell lines. The PCR-amplified 5¢ flanking region of human DPP-III gene (1038 bp) was cloned upstr...

Ngày tải lên: 29/03/2014, 09:20