báo cáo khoa học: " Collaboratively charting the gene-to-phenotype network of human congenital heart defects" ppt
báo cáo khoa học: " Collaboratively charting the gene-to-phenotype network of human congenital heart defects" ppt
... systems biology studies of numerous complex biological processes. © 2010 BioMed Central Ltd Collaboratively charting the gene-to-phenotype network of human congenital heart defects Roland Barriot 1,2,3† , ... engine executes these components when the page is rendered, or they can explicitly be called from within the page through the use of a specific tag. For ex...
Ngày tải lên: 11/08/2014, 12:20
Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... is composed of residues 25–540. The overall structure of the model of IPU and the mutated residues in this study are shown in Fig. 3. To elucidate the mechanism of the substrate recognition of IPU, ... panose (data not shown). Prediction of the positions of amino acid residues whose substitutions resulted in the reduction of the IPU activity While the study...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: "Methods for the Qualitative Evaluation of Lexical Association Measures" doc
... we find: (i) Examination of 50% of the data in the SLs leads to identification of between 75% (AdjN) and 80% (PNV) of the TPs. (ii) For the first 40% of the SLs, and lead to the worst results, with ... fre- quency) and the weak measures ( and ). In the second half of the data in the SLs, how- ever, there is virtually no difference between , , and the other measu...
Ngày tải lên: 20/02/2014, 18:20
Báo cáo khóa học: Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy pptx
... direct exploitation of the structural results of the former to explain the mechanism of CaM activation of the latter. Crystallization and resolution of the 3D structures of AC and AC–CaM, which ... respectively, the values of the center and the normalized amplitude of each lifetime peak. c I i are the values of the partial intensity of the i th compon...
Ngày tải lên: 07/03/2014, 15:20
Báo cáo khoa học: Bacitracin inhibits the reductive activity of protein disulfide isomerase by disulfide bond formation with free cysteines in the substrate-binding domain pptx
... ion mode CID-TOF ⁄ TOF MS analysis of the same precursor yielded the corresponding signature peaks (m ⁄ z 1404.88, 1438.82 and 1470.80) of the other part of the disulfide bond, i.e. the negatively ... making them the active antimicrobial compounds of the bacitracin mix. The oxidation of the amino-thiazoline ring to the keto-thiazole ring to form bacitracin H and F...
Ngày tải lên: 14/03/2014, 23:20
Báo cáo khoa học: Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein potx
... and His88 (hTTR number- ing), buried within the hydrophobic core of the mono- mers. The side chains of these residues form, together with the Ne1 atom of Trp79, hydrogen bonds with three or four ... hydrophobicity of molecules. Gel filtration chromatography of ecTRP in the presence and absence of 0.5% SDS in the running buffer produced monomers only when the SDS was i...
Ngày tải lên: 16/03/2014, 01:20
Báo cáo khoa học: Intrabodies against the EVH1 domain of Wiskott–Aldrich syndrome protein inhibit T cell receptor signaling in transgenic mice T cells potx
... region. The association of WASP and the Arp2 ⁄ 3 complex activates the actin nucleation activity of the Arp2 ⁄ 3 complex [23]. To investigate further the function of the WASP- EVH1 domain in the ... 5B). Therefore, the EVH1 domain of WASP is not func- tional, at least in the Ag receptor-induced proliferative response of B cells. T cells from the other three 21SHL...
Ngày tải lên: 16/03/2014, 14:20
Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx
... how the second kinase in the cascade determines the time dependence of the activity of the third kinase, we varied the V max of the second kinase reaction and recalculated the concentration of the ... of signaling are controlled by the kinases or phosphatases in the system, and whether they are controlled differ- entially by some or all of them. On the basi...
Ngày tải lên: 16/03/2014, 18:20
Báo cáo khoa học: "Search in the Lost Sense of “Query”: Question Formulation in Web Search Queries and its Temporal Change" pptx
... clustering but on understanding the expression of intent. 3 Method We address the main thesis of the work by retrospec- tively studying queries issued to a search engine over the course of 12 consecutive months. Q-queries. ... higher 7 An explanation of why the upward trend starts at the end of 2007 is beyond the scope of this work; we postulate that this coincides w...
Ngày tải lên: 17/03/2014, 00:20
Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx
... changes of the pro- tomer resulting in a displacement of the cofactor bound at the active site by 2.6 A ˚ (mean distance) in the direction of the iron and Glu286 which causes a loss of the stabilizing hydrogen ... conformation and hydrogen bonding network of the pterin cofactor in the three structures. Superpositions of the binary and ternary complexes of hPA...
Ngày tải lên: 17/03/2014, 09:20