báo cáo khoa học: " Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility" pdf

... and could be used to clarify the Minireview Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility Wolfgang Sadee Address: Program ... further assess new avenues that could lead to a better understanding of human health and disease. Measuring cis- and trans-acting factors in mRNA expression...

Ngày tải lên: 11/08/2014, 12:20

... acid and a base on each side of the hydrolyzed bond [16]. E96 and H137 in a-sarcin and E58 and H92 in RNase T1 act as the base and acid groups, respectively. Com- paring the 3D structures, E66 and ... hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins Aldino Viegas 1 , Elias Herrero-Gala ´ n 2 , Mercedes On ˜ aderra 2 , Anjos L. Mace...

Ngày tải lên: 18/02/2014, 08:20

... solution O. Delalande et al. 5092 FEBS Journal 277 (2010) 5086–5096 ª 2010 The Authors Journal compilation ª 2010 FEBS Cadmium – glutathione solution structures provide new insights into heavy metal ... for 15 N-GSH and 15 N- c-Glu- Cys were monitored at m ⁄ z 311 and 253, with retention times of 23 and 40 min, respectively. The fractions corre- sponding to these retention time ra...

Ngày tải lên: 15/03/2014, 00:20

... The 2nd and 3d columns show the total number of cues within the datasets; the 4th and 5th columns show the percentage of negated and spec- ulative sentences. 70% of the corpus documents (randomly ... ancestor of all cue and scope leaf nodes is shown in a box. combination of lexical and syntactic patterns. For example, ¨ Ozg ¨ ur and Radev (2009) examined sample BioScope sentences...

Ngày tải lên: 20/02/2014, 04:20

... prosody and the non- isomorphism of syntactic and phonological structure. We maintain that these are are central to the task of a morphological analyzer and, hence, have incorporated them into ... the syllables are /pa/, /ngu/, /pa/, /ngu/ and /rnu/ (the sequences ng and rn represent single segments), that the feet are /pangu/ and /pangurnu/ and that there is a single pr...

Ngày tải lên: 08/03/2014, 18:20

... consists of a lexicon and a grammar. The lexicon is a set of NEs that are known beforehand and have been classified into semantic classes. The grammar is used to recognize and classify NEs that ... classification, and partial matching of classified named-entities with unclassified ones. Classification rules take into account both internal and external evidence (McDonald, 1996),...

Ngày tải lên: 23/03/2014, 19:20

... the model and conduct mediation analysis of each translational phase. Qualitative data will expand on, challenge, and confirm survey findings and allow a more thorough understanding and convergent ... fields and community part ners are collaborating to bring perspec- tives and new insights from their disciplines. Second, findings will provide a toolbox of metrics, instrumental...

Ngày tải lên: 10/08/2014, 10:23

... of bri1-120 based on the inhibition of root growth and CPD expression in response to BL. On the other hand, both root and hypocotyl growth and BR sensitivity almost completely reverted to wild ... DNases (Promega), and the first-strand cDNA was synthesized using the SuperscriptⅢ-MMLV reverse transcriptase (Invitrogen) and oligo d(T 15 )primer. The same aliquot of first-strand cDNA...

Ngày tải lên: 11/08/2014, 11:21

... expanded, dierentiated and transplanted back into the patient for cell therapy. iPSCs from patients harboring genetic diseases can similarly be used as an in vitro disease model to study disease ... self-renew, and to dierentiate into all cell types of the body. This unique capacity of ESCs and iPSCs to form all cell lineages is termed pluripotency. While ESCs and iPSCs...

Ngày tải lên: 11/08/2014, 12:21

... 245 mm glutamate; and (c) glutamate and phosphate concentrations kept as they were measured, and compensa- tion of the remainder with 120 mm Pipes. Concentrations of substrates and coupling enzymes ... required [1]. For integration into models and exchange of experi- mental data from different research groups, it is essen- tial to standardize the cellular systems and experimenta...

Ngày tải lên: 06/03/2014, 09:22