báo cáo khoa học: " Complex disease genetics: present and future translational applications" pps

... the future of GWASs may lie in identifying rare (perhaps population-specific) high-impact variants and more complex structural variants, characterizing effects of genes and lifestyle, and ... mining the genome for complex traits. Finland’s integrated health care system provides detailed and uniform data used by scientists to delineate genetic contributions to disease. She...

Ngày tải lên: 11/08/2014, 12:20

... findings, blood pressure, and so on, for diagnosis of disease and choice of prevention or treatment. However, personalized treat- ment needs to combine clinical assessment and disease diagnostic ... Health Genomics, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS E61, Atlanta, GA 30333, USA. 4 Departments of Molecular and Human Genetics and Pediatric...

Ngày tải lên: 11/08/2014, 12:21

... 6:23 http://www.aacijournal.com/content/6/1/23 Page 7 of 8 REVIE W Open Access HAE therapies: past present and future Bruce L Zuraw Abstract Advances in understanding the pathophysiology and mechanism of swelling in hereditary angioedema (HAE) ... tolerated and most effective long-term prophylactic drugs are the synthetic anabolic androgens which increase C1INH plasma levels and d...

Ngày tải lên: 08/08/2014, 21:20

... 41 6.92 0.030 Complex Enolase 1 P06733 47.1 7.01 8 481 24 6.94 0.03 Complex RuvB-like 1 Q9Y265 50.2 6.02 10 343 28 11.58 0.009 Complex CRMP4 Q14195 61.9 6.04 2 81 4 13.02 0.007 Complex Lamin ... Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90. Immunol Lett 117, 9–15. 18 Brand IA & Heinickel A (1991) Key enzymes o...

Ngày tải lên: 15/02/2014, 01:20

... Jingyue Yang 1,2 and Richard W. Gross 1,2,3,4 1 Division of Bioorganic Chemistry and Molecular Pharmacology, and Departments of 2 Medicine, 3 Chemistry and 4 Molecular Biology and Pharmacology, ... against iPLA 2 c and visualization of immunoreactive bands by ECL. Expressed recombinant polypeptides are de sign ated according to their expected masses. Lanes 1 and 5, 88 kDa iPLA 2...

Ngày tải lên: 19/02/2014, 16:20

... PRC and ERRa in terms of respiratory efficiency. Overexpression of PRC and ERRa led to increased respiratory chain capacity and mitochondrial mass. The inhibition of ERR a decreased cell growth and ... Enzymatic activity of COX and CS, and the ratio of COX activity to CS activity. Results are the mean values ± SD of six experiments. D. Mirebeau-Prunier et al. ERRa-PRC complex an...

Ngày tải lên: 06/03/2014, 09:22

... the subcellular distribution and intracellular trans- port of GD3 and GM1, representative complex gangliosides from series ‘a’ and ‘b’, respectively. Using biochemical and fluorescent confocal microscopy, ... characterize the expression and subcellular localization of GD3 and GM1, representa- tive gangliosides from the ‘a’ and ‘b’ series, for whose identification we have valuabl...

Ngày tải lên: 16/03/2014, 04:20

... coli and Azotobacter vinelandii PDH complexes [7–9], and E. coli and A. vinelandii 2-oxoglutarate dehydrogenase complexes [10,11]; PSBD structures from E. coli 2-oxo- glutarate dehydrogenase and ... B. stearothermophilus PDH complexes [12,13]; the octahedral acyltransferase core from A. vinelandii PDH [14] and E. coli 2-oxo- glutarate dehydrogenase [15] complexes and the icosa- he...

Ngày tải lên: 16/03/2014, 18:20

... (eIF4GI) and I4G3_human (eIF4GII). (B) Comparison of the C-terminal extensions of FMDV Lb pro , ERAV Lb pro and ERBV Lb pro . Asterisks in (A) and (B) indicate conserved basic residues and acidic ... Q185 and E186 as balls -and- sticks. The catalytic residues C51 (alanine in the crystal structure [14]) and H148 are also shown. The drawing was produced using the program MOLSCRIPT...

Ngày tải lên: 23/03/2014, 13:20

... Education, Science, Culture and Sport, Japan (13226015 and 13854011) and for research on emerging and re-emerging infectious diseases from the Ministry of Health and Welfare. H. M. was supported ... ermentans complex II. Open boxes represent sdhC, sdhD, sdhA and sdhB genes encoding the CybL, CybS, Fp and Ip subunits, respectively, of the R. fermentans com- plex II. Locations o...

Ngày tải lên: 23/03/2014, 17:21