Báo cáo y học: "Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK" doc

... Inflammation Open Access Research Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK Suresh Shastry and Leighton R James* Address: ... not for citation purposes) Homocysteine-induced MIP- 2 is mediated by p38MAPK and PI3 kinaseFigure 2 Homocysteine-induced MIP- 2 is...

Ngày tải lên: 11/08/2014, 08:22

... matrix-associated proteoglycans (biglycan and fibromodulin) was also increased by FGF2 and hypoxia. Meniscus cells after expansion in monolayer can therefore respond to chondrogenic signals, and this is enhanced by ... cell aggregates, and this was unaffected by low oxygen. In non- FGF2-expanded cells, biglycan and fibromodulin expression was similar in monolayer and ce...

Ngày tải lên: 09/08/2014, 07:20

... of Dkk1 and UBE2D2 mRNA were analyzed by reverse transcriptase PCR. Cell lines and expression vectors are indicated. + RT and -RT denote cDNA synthesis with and without (mock synthesis) reverse ... differentiation of mesenchymal stem cells into mature osteoblasts [24], Dkk1 effectively reduces the population of these cells, thereby diminishing matrix synthesis. Concomitantly, Dkk...

Ngày tải lên: 13/08/2014, 01:20

... with 0.5% SDS and 0.5 mgÆmL )1 proteinase K for 15 min at 65 °C and subsequently for 1 h at 37 °C for DNA analysis, and were analyzed by 1% ag- arose gel electrophoresis followed by staining with ... and Ku in the aggregates is noteworthy because they function in a common pathway, and the protein kinase activity of DNA-PKcs is greatly stimulated by Ku during assembly at...

Ngày tải lên: 19/02/2014, 06:20

... 122 Sang-Hyun Kim and Yong-Hwan Kim including that reflected by the host intestine of cattle and/ or humans. In this regard, we hypothesized that curliation in EHEC O157:H7 may play a role in ... curliation. 120 Sang-Hyun Kim and Yong-Hwan Kim adherence to HEp-2 cells and that the adherence of curliated stain 4304 was also affected by alteration of the outer membrane integrity. M...

Ngày tải lên: 07/08/2014, 17:22

... (SIRS) is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and ... infection and strongly related to 28-day mortality. Background Sepsis is a systemic inflammatory response to a confirmed or suspected infection. Clinically, the Systemic Inflamma-...

Ngày tải lên: 25/10/2012, 09:56

... the anti -inflammatory activity of the NSAID is secondary to the COX-2 inhibition, and this activity is only marginally relevant to the hypersensitivity reactions elicited, as proven by the relative ... NSAID hypersensitivity on the basis of its inhibitory activity on the newly described enzyme, cyclooxygenase (COX)-3. This nonspecific sensitivity to inhibition of COX is most likel...

Ngày tải lên: 08/08/2014, 21:20

... use in adults and children over 6 years of age in the United States. Efficacy and safety Levocetirizine is a potent antihistamine as demonstrated by its ability to inhibit cutaneous histamine-induced ... bronchial hyper-responsiveness by act- ing indirectly via primed airway mast cells. This bronchial hyper-responsiveness correlates positively with eosi- nophilic asthmatic inflamma...

Ngày tải lên: 08/08/2014, 21:20

... synovial hyper- trophy (< 20 cell layers) with accumulation of inflammatory cells into intrasynovial cysts; 3 = pannus and fibrous tissue formation; and 4 = pannus and fibrous tissue formation ... develop synovitis with accompany- ing destruction of cartilage and bone structures [2,3]. This murine disease resembles the destructive polyarthritis of human RA and can be prevente...

Ngày tải lên: 09/08/2014, 01:23

... constantly expressed over the course of 7 days by microarray and reverse transcription-polymerase chain reaction (RT-PCR)mRNA transcripts constantly expressed over the course of 7 days by microarray and ... pro -inflammatory mediator in the acute ReA phase and might contribute to persistence by sustaining an inflammatory state, but this is speculative at the moment and need...

Ngày tải lên: 09/08/2014, 10:20