Báo cáo y học: "Early Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study" doc

... purposes) Journal of Inflammation Open Access Research Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study Chiara ... production induced by N- formylmethionyl-leucyl-phenylalanine (FMLP). Their effects on PMN adhesion to HUVEC were also invest...

Ngày tải lên: 11/08/2014, 08:21

... sequence of strain AY691679, using the Primer 5.0 software. The sequences of the primers * Correspondence: yijianzhong@yahoo.com Institute of Animal Husbandry Veterinary Sciences, Shanghai Academy of Agricultural ... analysis of old and new strains of porcine circovirus associated with congenital tremors in pigs and their comparison with strains involved with postweaning mul...

Ngày tải lên: 12/08/2014, 01:22

... positive regulation of prostaglandin E 2 (PGE 2 ) by TNF-α may play an important role in the regulation of human joint capsule MF function. Materials and methods Human hip joint capsules were ... inhibitor diclofenac (10 μg/mL) in DMEM containing 1% FCS. The expression of α-SMA and COX2 in MFs was determined by immunofluorescence double-staining using a primary monoclon...

Ngày tải lên: 12/08/2014, 11:22

... or ionizing radiation [6]. Observations of the Gerschman and the Harman groups reach bac k to the early 1950s and led to the assumption for a rela- tionship between ROS activity and toxic effects ... discussed [11-15]. The connection between ROS activity and cellu- lar toxicity is beyond controversial. Toxic effects like killing of eukaryotic and prokaryotic cells, stabl...

Ngày tải lên: 25/10/2012, 11:15

... analogs of GS, their relative potencies at perturbing the organization and increasing the permeability of phospholipid bilayer model membranes, and of causing the lysis of A. laidlawii B and human ... studies of the interaction of GS and its analogs with bacterial cells that the destruction of the integrity of the lipid bilayer of the inner membrane is the primary...

Ngày tải lên: 21/02/2014, 01:21

... by adenosine AMP, ADP and ATP. The significance of this is discussed in terms of current suggestions of the possible involvement of phosphorylation (or adenylation) in changes in the aggregational ... folds in general, these sites contain two mononucleotide binding sites; one for the nicotinamide and one for the adenosine moiety [31]. 2¢-Adenyl nucleotides, of the type fo...

Ngày tải lên: 22/02/2014, 04:20

... synthetase, inhibition of CoA-IT results in an increase in free AA and a corresponding build-up of AA in triacylglycerols that can be prevented by co-incubation of cells with CoA-synthetase inhibitors ... & Snyder, F. (1973) The enzymic incorporation of arachidonic acid into ether-containing choline and ethanolamine phosphoglycerides by deacylation-acylation reactions....

Ngày tải lên: 22/02/2014, 07:20

... stimulation of glycosaminoglycan release and nitric oxide production, and induction of fibrogenesis and muscle edema. In addition, induction of chondrogenesis within the synovial lining was observed. ... expressing human transforming growth factor; AIA = antigen-induced arthritis; ELISA = enzyme-linked immunosorbent assay; GAG = glycosaminoglycan; H & E = hematoxylin and...

Ngày tải lên: 09/08/2014, 01:21

... chondron size, individual chondrons were manually outlined using the MCID software, which then calculated chondron area. An average of 24 chondrons (range ± 13) that contained cells (usually only one ... important in CIA [38,39], particularly in inflammation induction and in the pas- sive transfer of antibody-mediated disease [10], successful treatment of inflammation can stil...

Ngày tải lên: 09/08/2014, 06:23

... have anti-inflammatory proper- ties depending on the timing of TNFα expression in a murine model of autoimmune diabetes [9]. One possibility to consider is that TNFα acts on cells of the joint ... IL-12 and IL-23, in human and mouse myeloid cells, respectively [11,12]. In summary, this paper raises intriguing questions about the diverse roles played by TNFα in adjuva...

Ngày tải lên: 09/08/2014, 10:23