Báo cáo khoa hoc:" Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration" doc

... 10:9 http://www.jnrbm.com/content/10/1/9 Page 2 of 7 RESEARCH Open Access Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration Marina ... in traumatic and degenerative human IVD tissue and correlated to the type of disease and the degree of degeneration (Th...

Ngày tải lên: 11/08/2014, 07:21

... [18]. Most of the previous studies concerning the function of the two isoforms refer to Lf, and do not discrimin- ate between the two Lf isoforms. Whereas only Lf is involved in various aspects of host ... polymorphisms in the human lactoferrin gene. Bio- chem Cell Biol 80, 17–22. 43 Teng C, Gladwell W, Raphiou I & Liu E (2004) Methy- lation and expression o...

Ngày tải lên: 30/03/2014, 08:20

... (data not shown). The VEGF120 isoform is the most abundant PCR product. The PCR reaction is more efficient for smaller PCR products and the abundance of the smallest VEGF isoform may reflect this. ... produce and respond to VEGF in inflamed tissues. Although an autocrine mechanism of macrophage activation is suggested, VEGFR-1 is also the target of placental gro...

Ngày tải lên: 07/03/2014, 12:20

... that the use of the p38 MAPK inhibitor, SB203580, only implicates the a and b isofroms of p38, as SB203580 has little or no effect on p38 c and d and it is possible that this could explain discrepancies ... PD098059 and U0126 on NF-jB DNA binding and NF-jB-dependent transcription To examine the role of the p38 and the ERK MAPK pathways, we examined the effe...

Ngày tải lên: 07/03/2014, 15:20

... simultane- ously, and one (2%) had the three types of metastasis since the start of metastatic disease. Results concerning the immunohistochemical expression of bcl-2 and deaths according to the three types of ... size and short follow-up time; and third, the interaction between the other members of the BCL-2 family may have neutralized the expression...

Ngày tải lên: 09/08/2014, 07:21

... tar- geted to both the microsomal and mitochondrial frac- tions of hepatic, brain and lung tissues, and also in cultured cells induced to express these proteins [9–13]. These studies gave rise to the ... mitochondrial import [11,13]. Therefore, we tested the importance of the Ser135 PKA site for the mitochondrial import of CYP2D6 by mutagenesis at this site (Fig. 5...

Ngày tải lên: 29/03/2014, 23:20

... interpretation of the results and to writing. W.S.T.G. contributed to the design of the study, interpretation of the results, and writing. S.W.B. made essential contributions to the design of the study and ... 60 N.A. Figure 4 9 DISCUSSION The neuroinflammagenic potential of IL-1β is shown here through its induction of synthesis of itself an...

Ngày tải lên: 19/06/2014, 22:20

... yzu@tmhs.org 1 Department of Pathology, the Methodist Hospital and the Methodist Hospital Research Institute, 6565 Fannin street, Houston, TX 77030, USA Full list of author information is available at the end of the ... 10 of 12 negatively-charged nature of both the siRNA and apta- mer that have complexed with the PEI-citrate nanocore. Further, the potential of...

Ngày tải lên: 11/08/2014, 00:22

... comprehension and inter- pretation of the question; b) recall of relevant informa- tion; and c) combination of the retrieved information. TheTourangeaumodeldoesnotincludetheuseof standards of comparison, ... whether the content of each distinct cognitive process underlying QoL appraisal is (dis)similar over time and whether patterns of (dis)similarity can be discerne...

Ngày tải lên: 12/08/2014, 01:21

... identify the errors, if any, present in the former and to formulate some hypotheses about their causes. On the basis of these hy- potheses, the Tutor selects the next exercise which will test the ... the Tutor will possibly switch to other topics. 4. THE DOMAIN EXPERT The Domain Expert is devoted to generate the fight answers for the exercises propose...

Ngày tải lên: 01/04/2014, 00:20