... human tumors,including those in the lung, head and neck, colon,pancreas, breast, ovary, bladder and kidney, and ingliomas. EGFR expression and cancer prognosis havebeen investigated in many ... and ERBB4.NRG1 and NRG2 bind to both ERBB3 and ERBB4,whereas NRG3 and NRG4 only bind to ERBB4 [3].Although these ligands show redundancy, heparin-binding-EGF is the only ligand whose absence ... Ferrand A, Kim Y, Sordella R, Bell DW,Haber DA, Anderson KS & Settleman J (2007)Epidermal growth factor receptor mutants from humanlung cancers exhibit enhanced catalytic activity and increased...