Báo cáo y học: "Novel anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet" pptx
Báo cáo y học: "Novel anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet" pptx
... insulinresistance, induction of SLPI locally in adipose may alsoplay a role in the prevention of inflammation-inducedinsulin resistance. In summary, we have demonstratedthat obesity is accompanied by increased ... anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet. Journal of Inflammation 2011 8:5.Submit your next manuscript to BioMed Central and take full advantage of: ... mechanism by which SLPI counteracts inflam-mation in adipocytes.DiscussionInflammation plays a major role in obesity-induced insu-lin resistance by the release of multiple inflammatorycytokines...
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Báo cáo y học: " Novel anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet" docx
... activated in adipose tissue in obesity [12,13], theinduction of SLPI in adipose tissue during obesity may beinfluenced by the activation state of the TLRs. Higherexpression of SLPI in the visceral ... anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet. Journal of Inflammation 2011 8:5.Submit your next manuscript to BioMed Central and take full advantage of: ... adipocytes and whole adi-pose tissue (Figures 2A, B and 2C). Regulation of SLPI expression in adipocytes by inflammatory stimuli and anti-inflammatory effect of SLPI Adipocytes express both TLR2 and...
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Báo cáo y học: " The potential role of appetite in predicting weight changes during treatment with olanzapine" ppt
... gain during antipsycho tic drugtherapy [15].An understanding of the role of appetite changes in weight gain during antipsychotic treatment would behelpful to clinicians and patients, some of ... Study 2); Eating Inventory (EI, Study 3) [20];Food Craving Inventory (FCI, Study 3) [21]; and Ea tingAttitude Scale (EAS, a Lilly-developed scale, assessingappetite and eating behavior during ... Karagianis, Treuer, and Hoffmann and Mr. Case are full-timeemployees and minor stockholders of Eli Lilly and Company and/ or any of its subsidiaries.Received: 22 February 2010 Accepted: 14 September...
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Báo cáo y học: "The expanding role of Tax in transcription" pdf
... co-immunoprecipitatedonly the phosphorylated form of RNAP II from HTLV-Iinfected cells. Thus, if only indirectly, Tax may increasekinase activity resulting in enhanced CTD phosphoryla-tion for steps following initiation, ... resulting in the loss of the capping machinery and the association of splicing,elongation and chromatin remodeling factors. In the case of HTLV-I, Tax has been shown not to associate with aCTD kinase ... E/cdk2kinase activity, through sequestration of cdk inhibitor,p21/waf1, by cyclin D2/cdk4 complexes [13,14]. Thiskinase complex was able to phosphorylate RNAP II CTD and antibodies against cyclin...
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Báo cáo khoa học: Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies pot
... identifying the role played by trans-acting factors in pseudoexon inclusion.However, because of its significance, this is an area of research that would probably benefit from increasedattention by ... Nishino I, Goto Y, Miike T & Nonaka I(1999) Newly recognized exons induced by a splicingabnormality from an intronic mutation of the dystro-phin gene resulting in Duchenne muscular dystrophy.Mutations ... J (2006) A splice-supporting intronic mutation in the last bp position of a cryptic exon within intron 6 of the CYBB geneinduces its incorporation into the mRNA causingchronic granulomatous...
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Báo cáo y học: "Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate" pot
... Matsushima Y, Kobayashi Y, Yamamoto T: Age estima-tion by measuring the racemization of aspartic acid from totalamino acid content of several types of bone and rib cartilage:a preliminary account. ... authors of that study further found that the hyaluronan-binding (G1) domain of aggrecan is retained early in the dis-ease process and then finally released to synovial fluid and sofollows a reciprocal ... clinical treatment and understanding, analogous tothe markers HbA1C in diabetes and αCTX-I/βCTX-1 in Pagetdisease of bone [36]. Furthermore, the role of IsoAsp in thepathophysiology of OA deserves...
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Báo cáo y học: "Capturing real-life patient care in psoriatic arthritis and its risks: the challenge of analysing registry data" docx
... adjudication of the reason for withdrawal. In summary, the study by Saad and colleagues gives usimportant insights into daily-life use of TNF inhibitors in PsA, adisease that too often is secondary to ... reason of ineffectiveness and terminated for the reason of toxicity. This was done by censoring patients with treatment terminations other than thereason of interest in the respective subanalysis. ... have reached the sameunsatisfying endpoint. This might, at least in part, explain thisparadox. In RA, therapy steered by an index has becomemore and more a mainstay of management as it has beenshown...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... wereresidues Gly261 and Gly262. The replacement of Gly262 by Ala resulted in an inactive enzyme. Substitution of Gly261 by Ala resulted to an enzyme with lower stability and increased energy of activation. ... Bouriotis1,21Department of Biology, Division of Applied Biology and Biotechnology, University of Crete, Greece;2Institute of Molecular Biology and Biotechnology (IMBB), Enzyme Technology Division, and the3Institute ... and subsequently their remaining activity was measured. Asshown in Fig. 3C, replacement of Gly261 by Ala in mutantG261A resulted in an enzyme with slightly lower stability.On the other hand, in the...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... presence of membrane-bound gp130 proteins by flow cytometry.COS7 cells were transiently transfected using the Fugenemethod. Efficiency of transfection was analysed by flowcytometry.Flow cytometryCells ... Deletion of a single domain in the membrane-proximal part of gp130leads to a shift of the receptor areas involved in ligandbinding closer to the membrane, resulting in the inability of the receptor ... bondbetween cysteines C458 and C466 [30].To analyse the role of the three cysteines in D5 of gp130 in heterodimerization with the LIFR, each of the cysteineswas mutated to alanine. Considering the...
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